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Arsenical keratosis

MedGen UID:
678533
•Concept ID:
C0854707
•
Disease or Syndrome
Synonym: Arsenical Keratosis
SNOMED CT: Arsenical keratosis (403741004); Arsenical keratosis (788579001)

Definition

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVArsenical keratosis

Professional guidelines

PubMed

Arsenicosis: diagnosis and treatment.
Das NK, Sengupta SR
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):571-81. doi: 10.4103/0378-6323.45098. PMID: 19171979
Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal.
Guha Mazumder DN
J Environ Sci Health A Tox Hazard Subst Environ Eng 2003 Jan;38(1):141-63. doi: 10.1081/ese-120016886. PMID: 12635824
Skin carcinomas and treatment with photochemotherapy (PUVA).
Lindskov R
Acta Derm Venereol 1983;63(3):223-6. PMID: 6192635

Recent clinical studies

Etiology

Patient-Reported Outcomes of Arsenic-Related Skin Lesions in China.
Li Y, Jing D, Xiao Y, Huang X, Shen M
Biomed Res Int 2020;2020:6195975. Epub 2020 Sep 17 doi: 10.1155/2020/6195975. PMID: 33015173Free PMC Article
Role of linoleic acid in arsenical palmar keratosis.
Ahmed TS, Misbahuddin M
Int J Dermatol 2016 Mar;55(3):289-95. Epub 2015 Jul 31 doi: 10.1111/ijd.12831. PMID: 26235890
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Khandpur S, Sharma VK
J Dermatol 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x. PMID: 14684956
Merkel cell carcinoma, Bowen's disease and chronic occupational arsenic poisoning.
Tsuruta D, Hamada T, Mochida K, Nakagawa K, Kobayashi H, Ishii M
Br J Dermatol 1998 Aug;139(2):291-4. doi: 10.1046/j.1365-2133.1998.02369.x. PMID: 9767246

Diagnosis

Arsenical Keratosis in Chronic Arsenic Intoxication.
Weng PC, Cheng CY
Mayo Clin Proc 2024 Sep;99(9):1518-1519. Epub 2024 Aug 5 doi: 10.1016/j.mayocp.2024.04.020. PMID: 39101865
Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases.
Hanly A, Turner N, Ko CJ, Panse G
Am J Dermatopathol 2024 Jul 1;46(7):439-442. Epub 2024 Apr 4 doi: 10.1097/DAD.0000000000002705. PMID: 38574081
Multiple minute digitate hyperkeratosis: a proposed algorithm for the digitate keratoses.
Caccetta TP, Dessauvagie B, McCallum D, Kumarasinghe SP
J Am Acad Dermatol 2012 Jul;67(1):e49-55. Epub 2010 Nov 3 doi: 10.1016/j.jaad.2010.07.023. PMID: 21050621
Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective.
Kessler GM, Ackerman AB
Am J Dermatopathol 2006 Dec;28(6):537-45. doi: 10.1097/01.dad.0000245196.73224.cb. PMID: 17122500
Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis?
Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen KH, Bieber T
Acta Derm Venereol 2000 Jul-Aug;80(4):292-3. doi: 10.1080/000155500750012207. PMID: 11028865

Therapy

Arsenical keratosis in China: A case report and review of the literature.
Tao R, Wang R
Skin Res Technol 2024 Sep;30(9):e13903. doi: 10.1111/srt.13903. PMID: 39189802Free PMC Article
Medical image. Horn that does not adorn. Arsenical keratosis.
Bandyopadhyay SK, Bandyopadhyay R, Dutta A
N Z Med J 2010 Feb 19;123(1309):111-3. PMID: 20186249
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Khandpur S, Sharma VK
J Dermatol 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x. PMID: 14684956
Electron microscopic observations of arsenical keratosis and Bowen's disease associated with chronic arsenicism.
Ohyama K, Sonoda K, Kuwahara H
Dermatologica 1982 Mar;164(3):161-6. doi: 10.1159/000250085. PMID: 7084538
Arsenical keratosis with squamous carcinoma of the skin, larynx, and lung.
Arch Dermatol 1965 Sep;92(3):326-7. doi: 10.1001/archderm.92.3.326. PMID: 11851260

Prognosis

Arsenical keratosis in China: A case report and review of the literature.
Tao R, Wang R
Skin Res Technol 2024 Sep;30(9):e13903. doi: 10.1111/srt.13903. PMID: 39189802Free PMC Article
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Khandpur S, Sharma VK
J Dermatol 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x. PMID: 14684956

Clinical prediction guides

Arsenic Keratosis in a Patient from Newfoundland and Labrador, Canada: Case Report and Review.
Pratt M, Wadden P, Gulliver W
J Cutan Med Surg 2016 Jan;20(1):67-71. Epub 2015 Aug 3 doi: 10.1177/1203475415599342. PMID: 26239734
Treatment of arsenical keratosis and Bowen's disease with acitretin.
Yerebakan O, Ermis O, Yilmaz E, Basaran E
Int J Dermatol 2002 Feb;41(2):84-7. doi: 10.1046/j.1365-4362.2002.01372.x. PMID: 11982642
Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis?
Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen KH, Bieber T
Acta Derm Venereol 2000 Jul-Aug;80(4):292-3. doi: 10.1080/000155500750012207. PMID: 11028865
Electron microscopic observations of arsenical keratosis and Bowen's disease associated with chronic arsenicism.
Ohyama K, Sonoda K, Kuwahara H
Dermatologica 1982 Mar;164(3):161-6. doi: 10.1159/000250085. PMID: 7084538

Recent systematic reviews

Arsenical keratosis in China: A case report and review of the literature.
Tao R, Wang R
Skin Res Technol 2024 Sep;30(9):e13903. doi: 10.1111/srt.13903. PMID: 39189802Free PMC Article

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