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Male Breast Carcinoma In Situ

MedGen UID:
673213
•Concept ID:
C0686328
•
Neoplastic Process

Definition

A proliferation of atypical neoplastic epithelial cells confined to the mammary ducts of the male breast. It includes the entire spectrum of carcinoma in situ observed in the female breast. It usually develops in the retroareolar region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMale Breast Carcinoma In Situ

Professional guidelines

PubMed

De-escalating treatment for ductal carcinoma in situ - Has the pendulum swung too far? (Invited Opinion).
Co M
Cancer Treat Res Commun 2021;28:100438. Epub 2021 Jul 17 doi: 10.1016/j.ctarc.2021.100438. PMID: 34298429
Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Senkus E, Kyriakides S, Penault-Llorca F, Poortmans P, Thompson A, Zackrisson S, Cardoso F; ESMO Guidelines Working Group
Ann Oncol 2013 Oct;24 Suppl 6:vi7-23. Epub 2013 Aug 22 doi: 10.1093/annonc/mdt284. PMID: 23970019
Identification, biopsy, and treatment of poorly understood premalignant, in situ, and indolent low-grade cancers: are we becoming victims of our own success?
Hall FM
Radiology 2010 Mar;254(3):655-9. doi: 10.1148/radiol.09092100. PMID: 20177083

Recent clinical studies

Etiology

NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.
Klümper N, Tran NK, Zschäbitz S, Hahn O, Büttner T, Roghmann F, Bolenz C, Zengerling F, Schwab C, Nagy D, Toma M, Kristiansen G, Heers H, Ivanyi P, Niegisch G, Grunewald CM, Darr C, Farid A, Schlack K, Abbas M, Aydogdu C, Casuscelli J, Mokry T, Mayr M, Niedersüß-Beke D, Rausch S, Dietrich D, Saal J, Ellinger J, Ritter M, Alajati A, Kuppe C, Meeks J, Vera Badillo FE, Nakauma-González JA, Boormans J, Junker K, Hartmann A, Grünwald V, Hölzel M, Eckstein M
J Clin Oncol 2024 Jul 10;42(20):2446-2455. Epub 2024 Apr 24 doi: 10.1200/JCO.23.01983. PMID: 38657187Free PMC Article
Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM
Cancer 2018 Apr 1;124(7):1358-1373. Epub 2018 Jan 16 doi: 10.1002/cncr.31125. PMID: 29338072Free PMC Article
Importance of cost-effectiveness and value in cancer care and healthcare policy.
Kang R, Goodney PP, Wong SL
J Surg Oncol 2016 Sep;114(3):275-80. Epub 2016 Jun 22 doi: 10.1002/jso.24331. PMID: 27334052Free PMC Article

Diagnosis

Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765
Paget's disease of the male breast with underlying ductal carcinoma in situ.
Leibou L, Herman O, Frand J, Kramer E, Mordechai S
Isr Med Assoc J 2015 Jan;17(1):64-5. PMID: 25739183
Identification, biopsy, and treatment of poorly understood premalignant, in situ, and indolent low-grade cancers: are we becoming victims of our own success?
Hall FM
Radiology 2010 Mar;254(3):655-9. doi: 10.1148/radiol.09092100. PMID: 20177083

Therapy

NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.
Klümper N, Tran NK, Zschäbitz S, Hahn O, Büttner T, Roghmann F, Bolenz C, Zengerling F, Schwab C, Nagy D, Toma M, Kristiansen G, Heers H, Ivanyi P, Niegisch G, Grunewald CM, Darr C, Farid A, Schlack K, Abbas M, Aydogdu C, Casuscelli J, Mokry T, Mayr M, Niedersüß-Beke D, Rausch S, Dietrich D, Saal J, Ellinger J, Ritter M, Alajati A, Kuppe C, Meeks J, Vera Badillo FE, Nakauma-González JA, Boormans J, Junker K, Hartmann A, Grünwald V, Hölzel M, Eckstein M
J Clin Oncol 2024 Jul 10;42(20):2446-2455. Epub 2024 Apr 24 doi: 10.1200/JCO.23.01983. PMID: 38657187Free PMC Article
De-escalating treatment for ductal carcinoma in situ - Has the pendulum swung too far? (Invited Opinion).
Co M
Cancer Treat Res Commun 2021;28:100438. Epub 2021 Jul 17 doi: 10.1016/j.ctarc.2021.100438. PMID: 34298429
Testosterone and Breast Cancer in Transmen: Case Reports, Review of the Literature, and Clinical Observation.
Tanini S, Fisher AD, Meattini I, Bianchi S, Ristori J, Maggi M, Lo Russo G
Clin Breast Cancer 2019 Apr;19(2):e271-e275. Epub 2018 Dec 20 doi: 10.1016/j.clbc.2018.12.006. PMID: 30655171
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM
Cancer 2018 Apr 1;124(7):1358-1373. Epub 2018 Jan 16 doi: 10.1002/cncr.31125. PMID: 29338072Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Prognosis

NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.
Klümper N, Tran NK, Zschäbitz S, Hahn O, Büttner T, Roghmann F, Bolenz C, Zengerling F, Schwab C, Nagy D, Toma M, Kristiansen G, Heers H, Ivanyi P, Niegisch G, Grunewald CM, Darr C, Farid A, Schlack K, Abbas M, Aydogdu C, Casuscelli J, Mokry T, Mayr M, Niedersüß-Beke D, Rausch S, Dietrich D, Saal J, Ellinger J, Ritter M, Alajati A, Kuppe C, Meeks J, Vera Badillo FE, Nakauma-González JA, Boormans J, Junker K, Hartmann A, Grünwald V, Hölzel M, Eckstein M
J Clin Oncol 2024 Jul 10;42(20):2446-2455. Epub 2024 Apr 24 doi: 10.1200/JCO.23.01983. PMID: 38657187Free PMC Article
Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM
Cancer 2018 Apr 1;124(7):1358-1373. Epub 2018 Jan 16 doi: 10.1002/cncr.31125. PMID: 29338072Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Clinical prediction guides

NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.
Klümper N, Tran NK, Zschäbitz S, Hahn O, Büttner T, Roghmann F, Bolenz C, Zengerling F, Schwab C, Nagy D, Toma M, Kristiansen G, Heers H, Ivanyi P, Niegisch G, Grunewald CM, Darr C, Farid A, Schlack K, Abbas M, Aydogdu C, Casuscelli J, Mokry T, Mayr M, Niedersüß-Beke D, Rausch S, Dietrich D, Saal J, Ellinger J, Ritter M, Alajati A, Kuppe C, Meeks J, Vera Badillo FE, Nakauma-González JA, Boormans J, Junker K, Hartmann A, Grünwald V, Hölzel M, Eckstein M
J Clin Oncol 2024 Jul 10;42(20):2446-2455. Epub 2024 Apr 24 doi: 10.1200/JCO.23.01983. PMID: 38657187Free PMC Article
Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Testosterone and Breast Cancer in Transmen: Case Reports, Review of the Literature, and Clinical Observation.
Tanini S, Fisher AD, Meattini I, Bianchi S, Ristori J, Maggi M, Lo Russo G
Clin Breast Cancer 2019 Apr;19(2):e271-e275. Epub 2018 Dec 20 doi: 10.1016/j.clbc.2018.12.006. PMID: 30655171
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM
Cancer 2018 Apr 1;124(7):1358-1373. Epub 2018 Jan 16 doi: 10.1002/cncr.31125. PMID: 29338072Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Recent systematic reviews

Aspects to consider regarding breast cancer risk in trans men: A systematic review and risk management approach.
Wahlström E, Audisio RA, Selvaggi G
PLoS One 2024;19(3):e0299333. Epub 2024 Mar 7 doi: 10.1371/journal.pone.0299333. PMID: 38451995Free PMC Article
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
The identification of incident cancers in UK primary care databases: a systematic review.
Rañopa M, Douglas I, van Staa T, Smeeth L, Klungel O, Reynolds R, Bhaskaran K
Pharmacoepidemiol Drug Saf 2015 Jan;24(1):11-8. Epub 2014 Nov 24 doi: 10.1002/pds.3729. PMID: 25421570
Cancer risk models and preselection for screening.
Stegeman I, Bossuyt PM
Cancer Epidemiol 2012 Oct;36(5):461-9. Epub 2012 Jul 25 doi: 10.1016/j.canep.2012.06.010. PMID: 22841151

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