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Left ventricular thrombus

MedGen UID:
668941
Concept ID:
C0587044
Pathologic Function
SNOMED CT: Left ventricular thrombus (309519009)
 
HPO: HP:0040412

Definition

A blood clot (thrombus) localized in the left ventricle. Left ventricular thrombus is a serious complication of acute myocardial infarction and also of non-ischemic cardiomyopathies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeft ventricular thrombus

Professional guidelines

PubMed

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Levine GN, McEvoy JW, Fang JC, Ibeh C, McCarthy CP, Misra A, Shah ZI, Shenoy C, Spinler SA, Vallurupalli S, Lip GYH; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2022 Oct 11;146(15):e205-e223. Epub 2022 Sep 15 doi: 10.1161/CIR.0000000000001092. PMID: 36106537
Honan KA, Jogimahanti A, Khair T
Am J Med 2022 Jan;135(1):17-23. Epub 2021 Aug 29 doi: 10.1016/j.amjmed.2021.07.023. PMID: 34469758

Recent clinical studies

Etiology

Levine GN, McEvoy JW, Fang JC, Ibeh C, McCarthy CP, Misra A, Shah ZI, Shenoy C, Spinler SA, Vallurupalli S, Lip GYH; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2022 Oct 11;146(15):e205-e223. Epub 2022 Sep 15 doi: 10.1161/CIR.0000000000001092. PMID: 36106537
Camaj A, Fuster V, Giustino G, Bienstock SW, Sternheim D, Mehran R, Dangas GD, Kini A, Sharma SK, Halperin J, Dweck MR, Goldman ME
J Am Coll Cardiol 2022 Mar 15;79(10):1010-1022. doi: 10.1016/j.jacc.2022.01.011. PMID: 35272796
Honan KA, Jogimahanti A, Khair T
Am J Med 2022 Jan;135(1):17-23. Epub 2021 Aug 29 doi: 10.1016/j.amjmed.2021.07.023. PMID: 34469758
Alcalai R, Butnaru A, Moravsky G, Yagel O, Rashad R, Ibrahimli M, Planer D, Amir O, Elbaz-Greener G, Leibowitz D
Eur Heart J Cardiovasc Pharmacother 2022 Sep 29;8(7):660-667. doi: 10.1093/ehjcvp/pvab057. PMID: 34279598
Shao C, Wang J, Tian J, Tang YD
Adv Exp Med Biol 2020;1177:1-36. doi: 10.1007/978-981-15-2517-9_1. PMID: 32246442

Diagnosis

Levine GN, McEvoy JW, Fang JC, Ibeh C, McCarthy CP, Misra A, Shah ZI, Shenoy C, Spinler SA, Vallurupalli S, Lip GYH; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2022 Oct 11;146(15):e205-e223. Epub 2022 Sep 15 doi: 10.1161/CIR.0000000000001092. PMID: 36106537
Camaj A, Fuster V, Giustino G, Bienstock SW, Sternheim D, Mehran R, Dangas GD, Kini A, Sharma SK, Halperin J, Dweck MR, Goldman ME
J Am Coll Cardiol 2022 Mar 15;79(10):1010-1022. doi: 10.1016/j.jacc.2022.01.011. PMID: 35272796
Alcalai R, Butnaru A, Moravsky G, Yagel O, Rashad R, Ibrahimli M, Planer D, Amir O, Elbaz-Greener G, Leibowitz D
Eur Heart J Cardiovasc Pharmacother 2022 Sep 29;8(7):660-667. doi: 10.1093/ehjcvp/pvab057. PMID: 34279598
Patel M, Wei X, Weigel K, Gertz ZM, Kron J, Robinson AA, Trankle CR
J Cardiovasc Pharmacol 2021 Sep 1;78(3):361-371. doi: 10.1097/FJC.0000000000001064. PMID: 34074905
Shao C, Wang J, Tian J, Tang YD
Adv Exp Med Biol 2020;1177:1-36. doi: 10.1007/978-981-15-2517-9_1. PMID: 32246442

Therapy

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Levine GN, McEvoy JW, Fang JC, Ibeh C, McCarthy CP, Misra A, Shah ZI, Shenoy C, Spinler SA, Vallurupalli S, Lip GYH; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2022 Oct 11;146(15):e205-e223. Epub 2022 Sep 15 doi: 10.1161/CIR.0000000000001092. PMID: 36106537
Zhang Z, Si D, Zhang Q, Jin L, Zheng H, Qu M, Yu M, Jiang Z, Li D, Li S, Yang P, He Y, Zhang W
JACC Cardiovasc Interv 2022 Apr 25;15(8):861-872. Epub 2022 Mar 30 doi: 10.1016/j.jcin.2022.01.285. PMID: 35367170
Camaj A, Fuster V, Giustino G, Bienstock SW, Sternheim D, Mehran R, Dangas GD, Kini A, Sharma SK, Halperin J, Dweck MR, Goldman ME
J Am Coll Cardiol 2022 Mar 15;79(10):1010-1022. doi: 10.1016/j.jacc.2022.01.011. PMID: 35272796
Alcalai R, Butnaru A, Moravsky G, Yagel O, Rashad R, Ibrahimli M, Planer D, Amir O, Elbaz-Greener G, Leibowitz D
Eur Heart J Cardiovasc Pharmacother 2022 Sep 29;8(7):660-667. doi: 10.1093/ehjcvp/pvab057. PMID: 34279598

Prognosis

Patel M, Wei X, Weigel K, Gertz ZM, Kron J, Robinson AA, Trankle CR
J Cardiovasc Pharmacol 2021 Sep 1;78(3):361-371. doi: 10.1097/FJC.0000000000001064. PMID: 34074905
Yassin AS, Abubakar H, Mishra T, Adam O, Hartman M, Pahuja M, Shokr M
Am J Ther 2019 Jul/Aug;26(4):e511-e515. doi: 10.1097/MJT.0000000000000726. PMID: 29420319
McCarthy CP, Vaduganathan M, McCarthy KJ, Januzzi JL Jr, Bhatt DL, McEvoy JW
JAMA Cardiol 2018 Jul 1;3(7):642-649. doi: 10.1001/jamacardio.2018.1086. PMID: 29800958
Habash F, Vallurupalli S
Ther Adv Cardiovasc Dis 2017 Aug;11(8):203-213. Epub 2017 Jun 7 doi: 10.1177/1753944717711139. PMID: 28589748Free PMC Article
Paelinck BP, Vrints CJ, Conraads VM
Can J Cardiol 2009 Nov;25(11):e390. doi: 10.1016/s0828-282x(09)70169-2. PMID: 19898705Free PMC Article

Clinical prediction guides

Patel M, Wei X, Weigel K, Gertz ZM, Kron J, Robinson AA, Trankle CR
J Cardiovasc Pharmacol 2021 Sep 1;78(3):361-371. doi: 10.1097/FJC.0000000000001064. PMID: 34074905
Jones DA, Wright P, Alizadeh MA, Fhadil S, Rathod KS, Guttmann O, Knight C, Timmis A, Baumbach A, Wragg A, Mathur A, Antoniou S
Eur Heart J Cardiovasc Pharmacother 2021 Sep 21;7(5):398-404. doi: 10.1093/ehjcvp/pvaa096. PMID: 32730627
Shao C, Wang J, Tian J, Tang YD
Adv Exp Med Biol 2020;1177:1-36. doi: 10.1007/978-981-15-2517-9_1. PMID: 32246442
McCarthy CP, Vaduganathan M, McCarthy KJ, Januzzi JL Jr, Bhatt DL, McEvoy JW
JAMA Cardiol 2018 Jul 1;3(7):642-649. doi: 10.1001/jamacardio.2018.1086. PMID: 29800958
Habash F, Vallurupalli S
Ther Adv Cardiovasc Dis 2017 Aug;11(8):203-213. Epub 2017 Jun 7 doi: 10.1177/1753944717711139. PMID: 28589748Free PMC Article

Recent systematic reviews

Haller PM, Kazem N, Agewall S, Borghi C, Ceconi C, Dobrev D, Cerbai E, Grove EL, Kaski JC, Lewis BS, Niessner A, Rocca B, Rosano G, Savarese G, Schnabel RB, Semb AG, Sossalla S, Wassmann S, Sulzgruber P
Eur Heart J Cardiovasc Pharmacother 2024 Aug 14;10(5):444-453. doi: 10.1093/ehjcvp/pvae042. PMID: 38845369
Shah S, Shah K, Turagam MK, Sharma A, Natale A, Lakkireddy D, Garg J
J Cardiovasc Electrophysiol 2021 Jun;32(6):1764-1771. Epub 2021 Apr 1 doi: 10.1111/jce.15016. PMID: 33772939
Bastiany A, Grenier ME, Matteau A, Mansour S, Daneault B, Potter BJ
Can J Cardiol 2017 Oct;33(10):1229-1236. Epub 2017 Aug 1 doi: 10.1016/j.cjca.2017.07.479. PMID: 28941605
Robinson AA, Jain A, Gentry M, McNamara RL
Int J Cardiol 2016 Oct 15;221:554-9. Epub 2016 Jul 6 doi: 10.1016/j.ijcard.2016.07.069. PMID: 27424314
de Gregorio C, Grimaldi P, Lentini C
Int J Cardiol 2008 Dec 17;131(1):18-24. Epub 2008 Aug 8 doi: 10.1016/j.ijcard.2008.05.060. PMID: 18692258

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