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Laryngeal granuloma

MedGen UID:
6674
•Concept ID:
C0018196
•
Disease or Syndrome
Synonyms: Granuloma of Larynx; Granuloma, Laryngeal; Granulomas, Laryngeal; Laryngeal Granuloma; Laryngeal Granulomas; Larynx Granuloma; Larynx Granulomas
SNOMED CT: Laryngeal granuloma (72211003)
 
Monarch Initiative: MONDO:0020974

Definition

An inflammatory lesion of the vocal cords. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal granuloma

Professional guidelines

PubMed

Arytenoid granuloma: a single-institution experience of management of 62 cases.
Gandhi S, Ganesuni D, Shenoy SS, Bhatta S, Ghanpur AD
J Laryngol Otol 2023 Feb;137(2):186-191. Epub 2021 Nov 25 doi: 10.1017/S0022215121003662. PMID: 34819183
Assessing the utility of non-surgical treatments in the management of vocal process granulomas.
Rudman JR, McGee CS, Diaz J, Rosow DE
J Laryngol Otol 2020 Jan;134(1):68-73. Epub 2020 Jan 10 doi: 10.1017/S0022215119002524. PMID: 31918788
Botulinum Toxin A for Treatment of Contact Granuloma.
Yılmaz T, Kayahan B, Günaydın RÖ, Kuşçu O, Sözen T
J Voice 2016 Nov;30(6):741-743. Epub 2015 Aug 19 doi: 10.1016/j.jvoice.2015.07.015. PMID: 26298840

Recent clinical studies

Etiology

Treatment Outcomes of Intralesional Steroid Injection for Refractory Vocal Process Granuloma.
Yu PJ, Hung WC, Wang CT
Clin Otolaryngol 2024 Nov;49(6):822-826. Epub 2024 Aug 12 doi: 10.1111/coa.14210. PMID: 39135379
Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Surgical Treatment Outcomes of Vocal Process Granuloma After Endotracheal Intubation.
Lee DH, Yoon TM, Lee JK, Lim SC
J Craniofac Surg 2018 Jun;29(4):e387-e389. doi: 10.1097/SCS.0000000000004389. PMID: 29481512
Interarytenoid botulinum toxin injection for recalcitrant vocal process granuloma.
Fink DS, Achkar J, Franco RA, Song PC
Laryngoscope 2013 Dec;123(12):3084-7. Epub 2013 Sep 20 doi: 10.1002/lary.23915. PMID: 24115127
Laryngeal effects of prolonged intubation.
Bishop MJ, Weymuller EA Jr, Fink BR
Anesth Analg 1984 Mar;63(3):335-42. PMID: 6367543

Diagnosis

A 51-Year-Old Man With Hoarseness of Voice.
Bass B, Shah V, Menon A, Tilley A
Chest 2020 Apr;157(4):e115-e119. doi: 10.1016/j.chest.2019.10.003. PMID: 32252935
Diagnosis and Treatment of Benign Pediatric Lesions.
Hron TA, Kavanagh KR, Murray N
Otolaryngol Clin North Am 2019 Aug;52(4):657-668. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.010. PMID: 31088693
Post-transplantation laryngeal actinomycosis.
Sei H, Nouta J, Miyaji S, Hato N
Auris Nasus Larynx 2019 Dec;46(6):917-920. Epub 2018 Dec 20 doi: 10.1016/j.anl.2018.12.006. PMID: 30579693
Vocal process granuloma.
Hoffman HT, Overholt E, Karnell M, McCulloch TM
Head Neck 2001 Dec;23(12):1061-74. doi: 10.1002/hed.10014. PMID: 11774392
Laryngeal manifestations of gout.
Guttenplan MD, Hendrix RA, Townsend MJ, Balsara G
Ann Otol Rhinol Laryngol 1991 Nov;100(11):899-902. doi: 10.1177/000348949110001108. PMID: 1746824

Therapy

A 51-Year-Old Man With Hoarseness of Voice.
Bass B, Shah V, Menon A, Tilley A
Chest 2020 Apr;157(4):e115-e119. doi: 10.1016/j.chest.2019.10.003. PMID: 32252935
Updated Medical and Surgical Treatment for Common Benign Laryngeal Lesions.
Kraimer KL, Husain I
Otolaryngol Clin North Am 2019 Aug;52(4):745-757. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.017. PMID: 31078305
Post-transplantation laryngeal actinomycosis.
Sei H, Nouta J, Miyaji S, Hato N
Auris Nasus Larynx 2019 Dec;46(6):917-920. Epub 2018 Dec 20 doi: 10.1016/j.anl.2018.12.006. PMID: 30579693
Laryngeal tuberculosis.
Krecicki T, Zalesska-Krecicka M, Zatonski T, Jankowska R, Skrzydlewska-Kaczmarek B
Lancet Infect Dis 2004 Jan;4(1):57. doi: 10.1016/s1473-3099(03)00863-6. PMID: 14720571
Laryngeal effects of prolonged intubation.
Bishop MJ, Weymuller EA Jr, Fink BR
Anesth Analg 1984 Mar;63(3):335-42. PMID: 6367543

Prognosis

Treatment Outcomes of Intralesional Steroid Injection for Refractory Vocal Process Granuloma.
Yu PJ, Hung WC, Wang CT
Clin Otolaryngol 2024 Nov;49(6):822-826. Epub 2024 Aug 12 doi: 10.1111/coa.14210. PMID: 39135379
Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.
Nie Q, Li J, Zou S, Zhang R
J Voice 2022 Sep;36(5):737.e17-737.e23. Epub 2020 Sep 8 doi: 10.1016/j.jvoice.2020.08.017. PMID: 32917458
Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma.
Damrose EJ, Damrose JF
J Laryngol Otol 2008 Aug;122(8):824-8. Epub 2007 Oct 2 doi: 10.1017/S0022215107000710. PMID: 17908354
Laryngeal granuloma: progression and resolution.
Sataloff RT, Hawkshaw M, Lyons KM, Spiegel JR
Ear Nose Throat J 1997 Sep;76(9):618. PMID: 9309902
Esophageal dysfunction in patients with contact ulcer of the larynx.
Ohman L, Olofsson J, Tibbling L, Ericsson G
Ann Otol Rhinol Laryngol 1983 May-Jun;92(3 Pt 1):228-30. doi: 10.1177/000348948309200303. PMID: 6859741

Clinical prediction guides

Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.
Nie Q, Li J, Zou S, Zhang R
J Voice 2022 Sep;36(5):737.e17-737.e23. Epub 2020 Sep 8 doi: 10.1016/j.jvoice.2020.08.017. PMID: 32917458
Post-transplantation laryngeal actinomycosis.
Sei H, Nouta J, Miyaji S, Hato N
Auris Nasus Larynx 2019 Dec;46(6):917-920. Epub 2018 Dec 20 doi: 10.1016/j.anl.2018.12.006. PMID: 30579693
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Surgical removal followed by radiotherapy for refractory vocal process granuloma.
Song Y, Shi L, Zhao Y, Zhao D, Shi M, Deng Z
J Voice 2012 Sep;26(5):666.e1-5. Epub 2011 Dec 29 doi: 10.1016/j.jvoice.2011.08.004. PMID: 22209061
Management of infant laryngeal disorders in relation to wound healing processes of the rabbit larynx.
Verwoerd-Verhoef HL, Hoeve LJ, Bean JK, Verwoerd CD
Acta Otorhinolaryngol Belg 1995;49(4):313-7. PMID: 8525827

Recent systematic reviews

Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Risk factors for laryngeal trauma and granuloma formation in pediatric intubations.
Jang M, Basa K, Levi J
Int J Pediatr Otorhinolaryngol 2018 Apr;107:45-52. Epub 2018 Jan 31 doi: 10.1016/j.ijporl.2018.01.008. PMID: 29501310
Vocal process granulomas: a systematic review of treatment.
Karkos PD, George M, Van Der Veen J, Atkinson H, Dwivedi RC, Kim D, Repanos C
Ann Otol Rhinol Laryngol 2014 May;123(5):314-20. Epub 2014 Mar 17 doi: 10.1177/0003489414525921. PMID: 24642585

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