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Bronchiolitis, Viral

MedGen UID:
666
•Concept ID:
C0006274
•
Disease or Syndrome
Synonyms: Bronchiolitides, Viral; Viral Bronchiolitides; Viral Bronchiolitis

Definition

An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchiolitis, Viral

Professional guidelines

PubMed

Viral bronchiolitis in young infants: new perspectives for management and treatment.
Caballero MT, Polack FP, Stein RT
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:75-83. Epub 2017 Aug 30 doi: 10.1016/j.jped.2017.07.003. PMID: 28859915
Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants.
Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A, Romagnoli C, Colonna P, Biondi A, Biban P, Chiamenti G, Bernardini R, Picca M, Cappa M, Magazzù G, Catassi C, Urbino AF, Memo L, Donzelli G, Minetti C, Paravati F, Di Mauro G, Festini F, Esposito S, Corsello G
Ital J Pediatr 2014 Oct 24;40:65. doi: 10.1186/1824-7288-40-65. PMID: 25344148Free PMC Article
Management of severe viral bronchiolitis and severe acute asthma.
Phelan PD, Stocks JG
Arch Dis Child 1974 Feb;49(2):143-8. doi: 10.1136/adc.49.2.143. PMID: 4817447Free PMC Article

Recent clinical studies

Etiology

Nirsevimab and Hospitalization for RSV Bronchiolitis.
Assad Z, Romain AS, Aupiais C, Shum M, Schrimpf C, Lorrot M, Corvol H, Prevost B, Ferrandiz C, Giolito A, Valtuille Z, Bendavid M, Cohen JF, Toubiana J, de Pontual L, Delande CF, Levy M, See P, Cohen R, Levy C, Angoulvant F, Lenglart L, Gits-Muselli M, Biran V, Diallo K, Alemede O, El Hebil MM, Durrmeyer X, Labouret G, Casanovas N, Hallak B, Maréchal O, Jung C, Bréhin C, Ouldali N
N Engl J Med 2024 Jul 11;391(2):144-154. doi: 10.1056/NEJMoa2314885. PMID: 38986058
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Viral bronchiolitis in young infants: new perspectives for management and treatment.
Caballero MT, Polack FP, Stein RT
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:75-83. Epub 2017 Aug 30 doi: 10.1016/j.jped.2017.07.003. PMID: 28859915
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Viral Bronchiolitis in Children.
Meissner HC
N Engl J Med 2016 Jan 7;374(1):62-72. doi: 10.1056/NEJMra1413456. PMID: 26735994

Diagnosis

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Bronchiolitis.
Dalziel SR, Haskell L, O'Brien S, Borland ML, Plint AC, Babl FE, Oakley E
Lancet 2022 Jul 30;400(10349):392-406. Epub 2022 Jul 1 doi: 10.1016/S0140-6736(22)01016-9. PMID: 35785792
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Viral bronchiolitis.
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article
Respiratory syncytial virus infection and bronchiolitis.
Piedimonte G, Perez MK
Pediatr Rev 2014 Dec;35(12):519-30. doi: 10.1542/pir.35-12-519. PMID: 25452661Free PMC Article

Therapy

Nirsevimab and Hospitalization for RSV Bronchiolitis.
Assad Z, Romain AS, Aupiais C, Shum M, Schrimpf C, Lorrot M, Corvol H, Prevost B, Ferrandiz C, Giolito A, Valtuille Z, Bendavid M, Cohen JF, Toubiana J, de Pontual L, Delande CF, Levy M, See P, Cohen R, Levy C, Angoulvant F, Lenglart L, Gits-Muselli M, Biran V, Diallo K, Alemede O, El Hebil MM, Durrmeyer X, Labouret G, Casanovas N, Hallak B, Maréchal O, Jung C, Bréhin C, Ouldali N
N Engl J Med 2024 Jul 11;391(2):144-154. doi: 10.1056/NEJMoa2314885. PMID: 38986058
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Bronchiolitis.
Dalziel SR, Haskell L, O'Brien S, Borland ML, Plint AC, Babl FE, Oakley E
Lancet 2022 Jul 30;400(10349):392-406. Epub 2022 Jul 1 doi: 10.1016/S0140-6736(22)01016-9. PMID: 35785792
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Viral bronchiolitis.
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article

Prognosis

Bronchiolitis.
Welliver JR, Welliver RC
Pediatr Rev 1993 Apr;14(4):134-9. doi: 10.1542/pir.14-4-134. PMID: 8516237
Imaging of small airways diseases.
Lynch DA
Clin Chest Med 1993 Dec;14(4):623-34. PMID: 8313667
Postgraduate course presentation. Infantile bronchial asthma.
Tabachnik E, Levison H
J Allergy Clin Immunol 1981 May;67(5):339-47. doi: 10.1016/0091-6749(81)90077-4. PMID: 6785335
Bronchiolitis or asthma?
Wittig HJ, Chang CH
Pediatr Clin North Am 1969 Feb;16(1):55-66. doi: 10.1016/s0031-3955(16)32234-9. PMID: 4885829
Aetiology and management of bronchiolitis and pneumonia in childhood.
Elderkin FM, Gardner PS, Turk DC, White AC
Br Med J 1965 Sep 25;2(5464):722-7. doi: 10.1136/bmj.2.5464.722. PMID: 5317929Free PMC Article

Clinical prediction guides

Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023-January 2024.
Paireau J, Durand C, Raimbault S, Cazaubon J, Mortamet G, Viriot D, Milesi C, Daudens-Vaysse E, Ploin D, Tessier S, Vanel N, Chappert JL, Levieux K, Ollivier R, Daoudi J, Coignard B, Leteurtre S, Parent-du-Châtelet I, Vaux S
Influenza Other Respir Viruses 2024 Jun;18(6):e13311. doi: 10.1111/irv.13311. PMID: 38840301Free PMC Article
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome.
Ghazaly MMH, Abu Faddan NH, Raafat DM, Mohammed NA, Nadel S
Eur J Pediatr 2021 Apr;180(4):1229-1234. Epub 2020 Nov 7 doi: 10.1007/s00431-020-03852-9. PMID: 33161501Free PMC Article
Immediate Effects and Safety of High-Frequency Chest Wall Compression Compared to Airway Clearance Techniques in Non-Hospitalized Infants With Acute Viral Bronchiolitis.
González-Bellido V, Velaz-Baza V, Blanco-Moncada E, Del Carmen Jimeno Esteo M, Cuenca-Zaldívar JN, Colombo-Marro A, Donadio MVF, Torres-Castro R
Respir Care 2021 Mar;66(3):425-433. Epub 2020 Nov 3 doi: 10.4187/respcare.08177. PMID: 33144386
Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L
BMJ Open 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. PMID: 31375615Free PMC Article

Recent systematic reviews

Lung ultrasound systematic review shows its prognostic and diagnostic role in acute viral bronchiolitis.
Kogias C, Prountzos S, Alexopoulou E, Douros K
Acta Paediatr 2023 Feb;112(2):222-232. Epub 2022 Oct 31 doi: 10.1111/apa.16578. PMID: 36261915
High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.
Moreel L, Proesmans M
Eur J Pediatr 2020 May;179(5):711-718. Epub 2020 Mar 31 doi: 10.1007/s00431-020-03637-0. PMID: 32232547
Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.
Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L
BMJ Open 2019 Aug 1;9(8):e028511. doi: 10.1136/bmjopen-2018-028511. PMID: 31375615Free PMC Article
Viral bronchiolitis in young infants: new perspectives for management and treatment.
Caballero MT, Polack FP, Stein RT
J Pediatr (Rio J) 2017 Nov-Dec;93 Suppl 1:75-83. Epub 2017 Aug 30 doi: 10.1016/j.jped.2017.07.003. PMID: 28859915
Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?
Drysdale SB, Milner AD, Greenough A
Acta Paediatr 2012 Nov;101(11):1114-20. Epub 2012 Sep 11 doi: 10.1111/j.1651-2227.2012.02825.x. PMID: 22963586

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