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Abnormal mean corpuscular hemoglobin concentration

MedGen UID:
663424
•Concept ID:
C0580549
•
Finding
Synonym: Abnormal mean corpuscular hemoglobin
SNOMED CT: MCH - abnormal (165442002); Mean corpuscular hemoglobin (MCH) - abnormal (165442002); Mean corpuscular hemoglobin abnormal (165442002); Mean corpuscular hemoglobin outside reference range (165442002)
 
HPO: HP:0025546

Definition

A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal mean corpuscular hemoglobin concentration

Professional guidelines

PubMed

Compound Heterozygosity for Hb Adana (HBA2: c.179G>A) and the -α(3.7)/αα Thalassemia Deletion in Greece: Clinical Phenotype and Genetic Counseling.
Theodoridou S, Teli A, Yfanti E, Vyzantiadis TA, Theodoridis T, Economou M
Hemoglobin 2018 Mar;42(2):129-131. Epub 2018 Jul 20 doi: 10.1080/03630269.2018.1466711. PMID: 30025477
Prenatal diagnosis of thalassaemia and fetal red cell microcytosis.
Ferrari M, Rajnoldi AC, Crema A, Pietri S, Travi M, Brambati B
Prenat Diagn 1982 Apr;2(2):143-5. doi: 10.1002/pd.1970020212. PMID: 7145841
Secondary polycythaemia: its causes, effects and treatment.
Harrison BD, Stokes TC
Br J Dis Chest 1982 Oct;76(4):313-40. doi: 10.1016/0007-0971(82)90067-5. PMID: 6758830

Recent clinical studies

Etiology

Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width.
Lippi G, Mattiuzzi C, Cervellin G
Acta Biomed 2016 Jan 16;87(3):323-328. PMID: 28112703Free PMC Article
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Thalassaemia trait and pregnancy.
White JM, Richards R, Byrne M, Buchanan T, White YS, Jelenski G
J Clin Pathol 1985 Jul;38(7):810-7. doi: 10.1136/jcp.38.7.810. PMID: 4019802Free PMC Article

Diagnosis

Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Red blood cell morphology.
Ford J
Int J Lab Hematol 2013 Jun;35(3):351-7. Epub 2013 Mar 9 doi: 10.1111/ijlh.12082. PMID: 23480230
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Therapy

Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.
Duez J, Holleran JP, Ndour PA, Pionneau C, Diakité S, Roussel C, Dussiot M, Amireault P, Avery VM, Buffet PA
Transfus Clin Biol 2015 Aug;22(3):151-7. Epub 2015 Jun 29 doi: 10.1016/j.tracli.2015.05.004. PMID: 26138907
Prognostic implication of macrocytosis on adverse outcomes after coronary intervention.
Myojo M, Iwata H, Kohro T, Sato H, Kiyosue A, Ando J, Sawaki D, Takahashi M, Fujita H, Hirata Y, Nagai R
Atherosclerosis 2012 Mar;221(1):148-53. Epub 2011 Dec 16 doi: 10.1016/j.atherosclerosis.2011.11.044. PMID: 22222418
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?
Niemelä O, Parkkila S
Addict Biol 2004 Mar;9(1):3-10. doi: 10.1080/13556210410001674031. PMID: 15203433

Prognosis

Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width.
Lippi G, Mattiuzzi C, Cervellin G
Acta Biomed 2016 Jan 16;87(3):323-328. PMID: 28112703Free PMC Article
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Erythrocyte electrolyte abnormalities.
Sciarra M, Cavaliere F, Bradariolo S, Proietti R, Magalini SI
Crit Care Med 1987 Nov;15(11):1006-8. doi: 10.1097/00003246-198711000-00003. PMID: 3677741
Thalassaemia trait and pregnancy.
White JM, Richards R, Byrne M, Buchanan T, White YS, Jelenski G
J Clin Pathol 1985 Jul;38(7):810-7. doi: 10.1136/jcp.38.7.810. PMID: 4019802Free PMC Article

Clinical prediction guides

Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width.
Lippi G, Mattiuzzi C, Cervellin G
Acta Biomed 2016 Jan 16;87(3):323-328. PMID: 28112703Free PMC Article
Red blood cell distribution width: A simple parameter with multiple clinical applications.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G
Crit Rev Clin Lab Sci 2015;52(2):86-105. Epub 2014 Dec 23 doi: 10.3109/10408363.2014.992064. PMID: 25535770
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968
Hemorheologic alterations in hypertension: chicken or egg?
Meiselman HJ
Clin Hemorheol Microcirc 1999;21(3-4):195-200. PMID: 10711743
Thalassaemia trait and pregnancy.
White JM, Richards R, Byrne M, Buchanan T, White YS, Jelenski G
J Clin Pathol 1985 Jul;38(7):810-7. doi: 10.1136/jcp.38.7.810. PMID: 4019802Free PMC Article

Recent systematic reviews

Clinical characteristics, laboratory abnormalities and CT findings of COVID-19 patients and risk factors of severe disease: a systematic review and meta-analysis.
Xie J, Wang Q, Xu Y, Zhang T, Chen L, Zuo X, Liu J, Huang L, Zhan P, Lv T, Song Y
Ann Palliat Med 2021 Feb;10(2):1928-1949. Epub 2021 Jan 27 doi: 10.21037/apm-20-1863. PMID: 33548996
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2018 Oct 19;10(10):CD003426. doi: 10.1002/14651858.CD003426.pub6. PMID: 30338520Free PMC Article
Folate supplementation in people with sickle cell disease.
Dixit R, Nettem S, Madan SS, Soe HHK, Abas AB, Vance LD, Stover PJ
Cochrane Database Syst Rev 2018 Mar 16;3(3):CD011130. doi: 10.1002/14651858.CD011130.pub3. PMID: 29546732Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2012 Jul 11;(7):CD003426. doi: 10.1002/14651858.CD003426.pub4. PMID: 22786485

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