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Abnormal red blood cell count

MedGen UID:
663423
•Concept ID:
C0580548
•
Finding
Synonyms: Abnormal RBC count; RBC (red blood cell) count abnormal; Red blood cell count abnormal; Red blood cell count outside reference range
SNOMED CT: Red blood cell count abnormal (165427000); Red blood cell count outside reference range (165427000); RBC (red blood cell) count abnormal (165427000)
 
HPO: HP:0020058

Definition

Any deviation from the normal number of red blood cells per volume in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal red blood cell count

Professional guidelines

PubMed

Hemolytic Anemia: Evaluation and Differential Diagnosis.
Phillips J, Henderson AC
Am Fam Physician 2018 Sep 15;98(6):354-361. PMID: 30215915
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Recent clinical studies

Etiology

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912
Assessment of splenic function.
de Porto AP, Lammers AJ, Bennink RJ, ten Berge IJ, Speelman P, Hoekstra JB
Eur J Clin Microbiol Infect Dis 2010 Dec;29(12):1465-73. Epub 2010 Sep 19 doi: 10.1007/s10096-010-1049-1. PMID: 20853172Free PMC Article
Postsplenectomy splenic activity.
Orda R, Barak J, Baron J, Spirer Z, Wiznitzer T
Ann Surg 1981 Dec;194(6):771-4. doi: 10.1097/00000658-198112000-00019. PMID: 7305494Free PMC Article

Diagnosis

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Hemolytic Anemia: Evaluation and Differential Diagnosis.
Phillips J, Henderson AC
Am Fam Physician 2018 Sep 15;98(6):354-361. PMID: 30215915
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura
J Thromb Haemost 2017 Feb;15(2):312-322. Epub 2017 Jan 30 doi: 10.1111/jth.13571. PMID: 27868334
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912

Therapy

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2018 Oct 19;10(10):CD003426. doi: 10.1002/14651858.CD003426.pub6. PMID: 30338520Free PMC Article
Hematologic and immunologic abnormalities in anorexia nervosa.
Kay J, Stricker RB
South Med J 1983 Aug;76(8):1008-10. doi: 10.1097/00007611-198308000-00018. PMID: 6348960
Health care delivery and the red blood cell.
Zipursky A
Can Med Assoc J 1980 Dec 20;123(12):1227-32. PMID: 7459761Free PMC Article
Phenacetin-induced haemolytic anaemia.
Davidson RJ
J Clin Pathol 1971 Sep;24(6):537-41. doi: 10.1136/jcp.24.6.537. PMID: 5094685Free PMC Article

Prognosis

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912
Congenital hypoplastic anemia.
Diamond LK, Wang WC, Alter BP
Adv Pediatr 1976;22:349-78. PMID: 773132
Congenital dyserythropoietic anaemia with erythroblastic multinuclearity.
Bright M, Cobb J, Evans B, Parry TE
J Clin Pathol 1972 Jul;25(7):561-9. doi: 10.1136/jcp.25.7.561. PMID: 5070252Free PMC Article

Clinical prediction guides

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2018 Oct 19;10(10):CD003426. doi: 10.1002/14651858.CD003426.pub6. PMID: 30338520Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes.
Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH, McFadden S, Vives-Corrons JL, Yutaka N, Lesesve JF; International Council for Standardization in Haematology (ICSH)
Int J Lab Hematol 2012 Apr;34(2):107-16. Epub 2011 Nov 15 doi: 10.1111/j.1751-553X.2011.01380.x. PMID: 22081912
Postsplenectomy splenic activity.
Orda R, Barak J, Baron J, Spirer Z, Wiznitzer T
Ann Surg 1981 Dec;194(6):771-4. doi: 10.1097/00000658-198112000-00019. PMID: 7305494Free PMC Article

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2018 Oct 19;10(10):CD003426. doi: 10.1002/14651858.CD003426.pub6. PMID: 30338520Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2012 Jul 11;(7):CD003426. doi: 10.1002/14651858.CD003426.pub4. PMID: 22786485
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Riddington C, De Franceschi L
Cochrane Database Syst Rev 2002;(4):CD003426. doi: 10.1002/14651858.CD003426. PMID: 12519597

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