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Decreased total iron binding capacity

MedGen UID:
663300
•Concept ID:
C0580419
•
Finding
Synonyms: TIBC - Total iron binding capacity low; Total iron binding capacity below reference range; Total iron binding capacity low
SNOMED CT: TIBC - Total iron binding capacity low (165630002); Total iron binding capacity low (165630002); Total iron binding capacity below reference range (165630002)
 
HPO: HP:0033211

Definition

A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased total iron binding capacity

Professional guidelines

PubMed

Management of iron deficiency anaemia in gynaecological patients at Jinnah Postgraduate Medical Centre, Karachi.
Nasir A, Yasmin H, Korejo R
J Pak Med Assoc 2011 Oct;61(10):998-1001. PMID: 22356035

Recent clinical studies

Etiology

Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms.
Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Sci Rep 2019 Apr 15;9(1):6054. doi: 10.1038/s41598-019-42622-y. PMID: 30988354Free PMC Article
Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.
Imaeda T, Nakada TA, Abe R, Oda S
PLoS One 2019;14(1):e0210067. Epub 2019 Jan 23 doi: 10.1371/journal.pone.0210067. PMID: 30673726Free PMC Article
Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.
Qiao L, Tang Q, Zhu W, Zhang H, Zhu Y, Wang H
Medicine (Baltimore) 2017 Mar;96(9):e5795. doi: 10.1097/MD.0000000000005795. PMID: 28248850Free PMC Article
Transmetallation and gadolinium: do low iron stores prevent the development of nephrogenic systemic fibrosis in high-risk end-stage renal disease patients?
Panesar M, Boateng F, Patel SS, Masood SF, Mahajan P, Patel N, Murray B
Hemodial Int 2010 Jul;14(3):289-94. doi: 10.1111/j.1542-4758.2010.00456.x. PMID: 20662951
Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes.
Campbell WW, Beard JL, Joseph LJ, Davey SL, Evans WJ
Am J Clin Nutr 1997 Oct;66(4):944-9. doi: 10.1093/ajcn/66.4.944. PMID: 9322572

Diagnosis

Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms.
Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Sci Rep 2019 Apr 15;9(1):6054. doi: 10.1038/s41598-019-42622-y. PMID: 30988354Free PMC Article
Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.
Imaeda T, Nakada TA, Abe R, Oda S
PLoS One 2019;14(1):e0210067. Epub 2019 Jan 23 doi: 10.1371/journal.pone.0210067. PMID: 30673726Free PMC Article
Evaluation of microcytosis.
Van Vranken M
Am Fam Physician 2010 Nov 1;82(9):1117-22. PMID: 21121557
Transmetallation and gadolinium: do low iron stores prevent the development of nephrogenic systemic fibrosis in high-risk end-stage renal disease patients?
Panesar M, Boateng F, Patel SS, Masood SF, Mahajan P, Patel N, Murray B
Hemodial Int 2010 Jul;14(3):289-94. doi: 10.1111/j.1542-4758.2010.00456.x. PMID: 20662951

Therapy

Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.
Qiao L, Tang Q, Zhu W, Zhang H, Zhu Y, Wang H
Medicine (Baltimore) 2017 Mar;96(9):e5795. doi: 10.1097/MD.0000000000005795. PMID: 28248850Free PMC Article
Transmetallation and gadolinium: do low iron stores prevent the development of nephrogenic systemic fibrosis in high-risk end-stage renal disease patients?
Panesar M, Boateng F, Patel SS, Masood SF, Mahajan P, Patel N, Murray B
Hemodial Int 2010 Jul;14(3):289-94. doi: 10.1111/j.1542-4758.2010.00456.x. PMID: 20662951
Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes.
Campbell WW, Beard JL, Joseph LJ, Davey SL, Evans WJ
Am J Clin Nutr 1997 Oct;66(4):944-9. doi: 10.1093/ajcn/66.4.944. PMID: 9322572
Anemia of chronic disorders in systemic autoimmune diseases.
Bertero MT, Caligaris-Cappio F
Haematologica 1997 May-Jun;82(3):375-81. PMID: 9234597
Correction of anemia and iron deficiency in vegetarians by administration of ascorbic acid.
Sharma DC, Mathur R
Indian J Physiol Pharmacol 1995 Oct;39(4):403-6. PMID: 8582755

Prognosis

Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.
Imaeda T, Nakada TA, Abe R, Oda S
PLoS One 2019;14(1):e0210067. Epub 2019 Jan 23 doi: 10.1371/journal.pone.0210067. PMID: 30673726Free PMC Article

Clinical prediction guides

Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.
Imaeda T, Nakada TA, Abe R, Oda S
PLoS One 2019;14(1):e0210067. Epub 2019 Jan 23 doi: 10.1371/journal.pone.0210067. PMID: 30673726Free PMC Article
Anemia of chronic disorders in systemic autoimmune diseases.
Bertero MT, Caligaris-Cappio F
Haematologica 1997 May-Jun;82(3):375-81. PMID: 9234597
Deficiency of serum bactericidal activity against Salmonella typhimurium in sickle cell anaemia.
Hand WL, King NL
Clin Exp Immunol 1977 Nov;30(2):262-70. PMID: 342154Free PMC Article

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