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Orthodeoxia

MedGen UID:
637029
•Concept ID:
C0522073
•
Finding
Synonym: Orthodeoxias
SNOMED CT: Orthodeoxia (102633001)
 
HPO: HP:0033367

Definition

Low level of blood oxygen induced by changing from a recumbent to an upright position. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrthodeoxia

Professional guidelines

PubMed

Importance of platypnea orthodeoxia in the differential diagnosis of dyspnea.
Takase B, Tanaka Y, Hattori H, Ishihara M
Intern Med 2012;51(13):1651-2. Epub 2012 Jul 1 doi: 10.2169/internalmedicine.51.7720. PMID: 22790121
Patent foramen ovale--assessment and treatment.
Irwin B, Ray S
Cardiovasc Ther 2012 Jun;30(3):e128-35. Epub 2011 Feb 15 doi: 10.1111/j.1755-5922.2010.00250.x. PMID: 21883994
Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management.
Cheng TO
Catheter Cardiovasc Interv 1999 May;47(1):64-6. doi: 10.1002/(SICI)1522-726X(199905)47:1<64::AID-CCD15>3.0.CO;2-6. PMID: 10385164

Recent clinical studies

Etiology

The pathophysiology of patent foramen ovale and its related complications.
Shah AH, Horlick EM, Kass M, Carroll JD, Krasuski RA
Am Heart J 2024 Nov;277:76-92. Epub 2024 Aug 10 doi: 10.1016/j.ahj.2024.08.001. PMID: 39134216
Updates on Patent Foramen Ovale (PFO) Closure.
Voudris KV, Poulin MF, Kavinsky CJ
Curr Cardiol Rep 2024 Jul;26(7):735-746. Epub 2024 Jun 24 doi: 10.1007/s11886-024-02073-y. PMID: 38913234
Patent Foramen Ovale: Pivotal Role of Transesophageal Echocardiography in the Indications for Closure, Assessment of Varying Anatomies and Post-procedure Follow-up.
Vitarelli A
Ultrasound Med Biol 2019 Aug;45(8):1882-1895. Epub 2019 May 17 doi: 10.1016/j.ultrasmedbio.2019.04.015. PMID: 31104864
Pulmonary Arteriovenous Malformations and Risk of Stroke.
Holzer RJ, Cua CL
Cardiol Clin 2016 May;34(2):241-6. Epub 2016 Mar 18 doi: 10.1016/j.ccl.2016.01.001. PMID: 27150172
Patent foramen ovale: clinical manifestations and treatment.
Kedia G, Tobis J, Lee MS
Rev Cardiovasc Med 2008 Summer;9(3):168-73. PMID: 18953276

Diagnosis

Patent Foramen Ovale and Hypoxemia.
Nguyen A, Nguyen E, Kumar P
Cardiol Clin 2024 Nov;42(4):509-519. Epub 2024 Feb 28 doi: 10.1016/j.ccl.2024.01.008. PMID: 39322341
The Shunt of It.
Scarpato BM, McDonald J, Bayrak-Toydemir P, Elliott CG, Cahill BC, Emerson LL, Keenan LM
Chest 2023 May;163(5):e201-e205. doi: 10.1016/j.chest.2023.01.020. PMID: 37164583Free PMC Article
Platypnoea-orthodeoxia syndrome as an uncommon cause of dyspnoea: a literature review.
Lombardi M, Del Buono MG, Princi G, Locorotondo G, Lombardo A, Vergallo R, Montone RA, Burzotta F, Trani C, Crea F, Sanna T
Intern Med J 2022 Jun;52(6):921-925. Epub 2022 Apr 4 doi: 10.1111/imj.15669. PMID: 34935270Free PMC Article
Patent Foramen Ovale Closure for Hypoxemia.
Tobis JM, Narasimha D, Abudayyeh I
Interv Cardiol Clin 2017 Oct;6(4):547-554. Epub 2017 Jul 3 doi: 10.1016/j.iccl.2017.05.003. PMID: 28886845
The multiple dimensions of Platypnea-Orthodeoxia syndrome: A review.
Agrawal A, Palkar A, Talwar A
Respir Med 2017 Aug;129:31-38. Epub 2017 May 31 doi: 10.1016/j.rmed.2017.05.016. PMID: 28732833

Therapy

Platypnea-Orthodeoxia Syndrome Following Transcatheter Aortic Valve Replacement.
Küçükseymen S, Ciardetti N, Stolcova M, Di Mario C, Meucci F
Anatol J Cardiol 2023 Sep 1;27(9):549-551. Epub 2023 Aug 1 doi: 10.14744/AnatolJCardiol.2023.3217. PMID: 37551749Free PMC Article
Paralytic ileus precipitating platypnoea-orthodeoxia after right pneumonectomy.
Whiteley J, Lynn P, Walker N, Butler J
Eur J Cardiothorac Surg 2020 Jan 1;57(1):189-190. doi: 10.1093/ejcts/ezz212. PMID: 31363746
Platypnoea-orthodeoxia after left total knee replacement.
Almufti T, Eversheim F, Johnson B, Akra GA
BMJ Case Rep 2019 Oct 23;12(10) doi: 10.1136/bcr-2019-230771. PMID: 31645396Free PMC Article
Refractory Hypoxemia After Laparoscopic Nissen Fundoplication.
Rochlani Y, Vallurupalli S, Hakeem A, Bhatti S
Can J Cardiol 2016 Mar;32(3):395.e1-3. Epub 2015 Jul 3 doi: 10.1016/j.cjca.2015.06.027. PMID: 26481081
Patent foramen ovale: clinical manifestations and treatment.
Kedia G, Tobis J, Lee MS
Rev Cardiovasc Med 2008 Summer;9(3):168-73. PMID: 18953276

Prognosis

Patent Foramen Ovale: Pivotal Role of Transesophageal Echocardiography in the Indications for Closure, Assessment of Varying Anatomies and Post-procedure Follow-up.
Vitarelli A
Ultrasound Med Biol 2019 Aug;45(8):1882-1895. Epub 2019 May 17 doi: 10.1016/j.ultrasmedbio.2019.04.015. PMID: 31104864
Pulmonary Arteriovenous Malformations and Risk of Stroke.
Holzer RJ, Cua CL
Cardiol Clin 2016 May;34(2):241-6. Epub 2016 Mar 18 doi: 10.1016/j.ccl.2016.01.001. PMID: 27150172
Current status of percutaneous PFO closure.
Rohrhoff N, Vavalle JP, Halim S, Kiefer TL, Harrison JK
Curr Cardiol Rep 2014 May;16(5):477. doi: 10.1007/s11886-014-0477-4. PMID: 24633647
A case of unexplained cyanosis.
Soma P, Ellemdin S
Cardiovasc J Afr 2012 Sep 12;23(8):e11-2. doi: 10.5830/CVJA-2012-033. PMID: 23044525
Patent foramen ovale and stroke.
Horton SC, Bunch TJ
Mayo Clin Proc 2004 Jan;79(1):79-88. doi: 10.4065/79.1.79. PMID: 14708951

Clinical prediction guides

The pathophysiology of patent foramen ovale and its related complications.
Shah AH, Horlick EM, Kass M, Carroll JD, Krasuski RA
Am Heart J 2024 Nov;277:76-92. Epub 2024 Aug 10 doi: 10.1016/j.ahj.2024.08.001. PMID: 39134216
Updates on Patent Foramen Ovale (PFO) Closure.
Voudris KV, Poulin MF, Kavinsky CJ
Curr Cardiol Rep 2024 Jul;26(7):735-746. Epub 2024 Jun 24 doi: 10.1007/s11886-024-02073-y. PMID: 38913234
Reversible platypnoea-orthodeoxia syndrome.
Joseph TJ, Isaac BT, James P, Thangakunam B
BMJ Case Rep 2023 Oct 31;16(10) doi: 10.1136/bcr-2023-255587. PMID: 37907322Free PMC Article
Platypnoea and orthodeoxia in the hepatopulmonary syndrome.
Surridge A, Atkinson J, Aujayeb A
BMJ Case Rep 2019 Nov 26;12(11) doi: 10.1136/bcr-2019-231499. PMID: 31776152Free PMC Article
Patent Foramen Ovale and Hypoxemia.
Mojadidi MK, Ruiz JC, Chertoff J, Zaman MO, Elgendy IY, Mahmoud AN, Al-Ani M, Elgendy AY, Patel NK, Shantha G, Tobis JM, Meier B
Cardiol Rev 2019 Jan/Feb;27(1):34-40. doi: 10.1097/CRD.0000000000000205. PMID: 29570476

Recent systematic reviews

Posture Dependent Hypoxia Following Lobectomy: The Achilles Tendon of the Lung Surgeon?
Krassas A, Tzifa A, Boulia S, Iliadis K
J Invest Surg 2022 Jan;35(1):180-185. Epub 2020 Dec 2 doi: 10.1080/08941939.2020.1825883. PMID: 33263463

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