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Neonatal melena

MedGen UID:
634842
•Concept ID:
C0475598
•
Pathologic Function
Synonyms: Melena Neonatal; Melena Neonatorum; Neonatal Melena
SNOMED CT: Neonatal melena (206424005)

Definition

Abnormally dark tarry feces containing blood, usually due to gastrointestinal bleeding or swallowed maternal blood in neonates. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal melena

Professional guidelines

PubMed

Gastrointestinal Bleeding and Management.
Pai AK, Fox VL
Pediatr Clin North Am 2017 Jun;64(3):543-561. doi: 10.1016/j.pcl.2017.01.014. PMID: 28502437
Gastrointestinal Infantile Hemangioma: Presentation and Management.
Soukoulis IW, Liang MG, Fox VL, Mulliken JB, Alomari AI, Fishman SJ
J Pediatr Gastroenterol Nutr 2015 Oct;61(4):415-20. doi: 10.1097/MPG.0000000000000812. PMID: 25859824
A multicenter, multiyear study of the safety and clinical utility of esophagogastroduodenoscopy in 20 consecutive pregnant females with follow-up of fetal outcome.
Cappell MS, Sidhom O
Am J Gastroenterol 1993 Nov;88(11):1900-5. PMID: 8237939

Recent clinical studies

Etiology

Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.
Motoki T, Naomoto Y, Hoshiba J, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M, Tomono Y, Fujiwara Y, Tsuchita H, Gunduz M, Nagatsuka H, Tanaka N, Fujiwara T
World J Gastroenterol 2011 Feb 14;17(6):717-26. doi: 10.3748/wjg.v17.i6.717. PMID: 21390141Free PMC Article

Therapy

Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.
Motoki T, Naomoto Y, Hoshiba J, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M, Tomono Y, Fujiwara Y, Tsuchita H, Gunduz M, Nagatsuka H, Tanaka N, Fujiwara T
World J Gastroenterol 2011 Feb 14;17(6):717-26. doi: 10.3748/wjg.v17.i6.717. PMID: 21390141Free PMC Article

Clinical prediction guides

Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.
Motoki T, Naomoto Y, Hoshiba J, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M, Tomono Y, Fujiwara Y, Tsuchita H, Gunduz M, Nagatsuka H, Tanaka N, Fujiwara T
World J Gastroenterol 2011 Feb 14;17(6):717-26. doi: 10.3748/wjg.v17.i6.717. PMID: 21390141Free PMC Article

Supplemental Content

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    Practice guidelines

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