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Meconium aspiration syndrome

MedGen UID:
6258
•Concept ID:
C0025048
•
Disease or Syndrome
Synonyms: Aspiration Syndrome, Meconium; Aspiration, Meconium; Meconium Aspiration; Meconium Aspiration Syndrome; Meconium Inhalation; Syndrome, Meconium Aspiration
SNOMED CT: Meconium aspiration syndrome (206292002); MAS - meconium aspiration syndrome (206292002); Neonatal aspiration of meconium (206292002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0006851
Orphanet: ORPHA70588

Definition

Meconium aspiration syndrome is a pulmonary complication appearing in newborns with a meconium-stained amniotic fluid. Aspirated meconium can interfere with normal breathing by several mechanisms including airway obstruction, chemical irritation, infection and surfactant inactivation and induces more or less severe signs of respiratory distress at birth. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeconium aspiration syndrome
Follow this link to review classifications for Meconium aspiration syndrome in Orphanet.

Professional guidelines

PubMed

Current Concepts in the Management of Meconium Aspiration Syndrome.
Chettri S, Bhat BV, Adhisivam B
Indian J Pediatr 2016 Oct;83(10):1125-30. Epub 2016 May 21 doi: 10.1007/s12098-016-2128-9. PMID: 27206687
Update on PPHN: mechanisms and treatment.
Nair J, Lakshminrusimha S
Semin Perinatol 2014 Mar;38(2):78-91. doi: 10.1053/j.semperi.2013.11.004. PMID: 24580763Free PMC Article
Surfactant replacement therapy for preterm and term neonates with respiratory distress.
Polin RA, Carlo WA; Committee on Fetus and Newborn; American Academy of Pediatrics
Pediatrics 2014 Jan;133(1):156-63. Epub 2013 Dec 30 doi: 10.1542/peds.2013-3443. PMID: 24379227

Recent clinical studies

Etiology

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Respiratory distress of the term newborn infant.
Edwards MO, Kotecha SJ, Kotecha S
Paediatr Respir Rev 2013 Mar;14(1):29-36; quiz 36-7. Epub 2012 Mar 2 doi: 10.1016/j.prrv.2012.02.002. PMID: 23347658
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Respiratory distress in the newborn.
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Diagnosis

Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Newborn Respiratory Distress.
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Respiratory distress in the newborn.
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Therapy

Meconium aspiration syndrome: a comprehensive review.
Osman A, Halling C, Crume M, Al Tabosh H, Odackal N, Ball MK
J Perinatol 2023 Oct;43(10):1211-1221. Epub 2023 Aug 5 doi: 10.1038/s41372-023-01708-2. PMID: 37543651
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Update on PPHN: mechanisms and treatment.
Nair J, Lakshminrusimha S
Semin Perinatol 2014 Mar;38(2):78-91. doi: 10.1053/j.semperi.2013.11.004. PMID: 24580763Free PMC Article

Prognosis

Induction of labour at 41 weeks versus expectant management and induction of labour at 42 weeks (SWEdish Post-term Induction Study, SWEPIS): multicentre, open label, randomised, superiority trial.
Wennerholm UB, Saltvedt S, Wessberg A, Alkmark M, Bergh C, Wendel SB, Fadl H, Jonsson M, Ladfors L, Sengpiel V, Wesström J, Wennergren G, Wikström AK, Elden H, Stephansson O, Hagberg H
BMJ 2019 Nov 20;367:l6131. doi: 10.1136/bmj.l6131. PMID: 31748223Free PMC Article
Meconium aspiration syndrome: risk factors and predictors of severity.
Oliveira CPL, Flôr-de-Lima F, Rocha GMD, Machado AP, Guimarães Pereira Areias MHF
J Matern Fetal Neonatal Med 2019 May;32(9):1492-1498. Epub 2017 Dec 8 doi: 10.1080/14767058.2017.1410700. PMID: 29219011
Meconium "aspiration" (or respiratory distress associated with meconium-stained amniotic fluid?).
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Respiratory distress of the term newborn infant.
Edwards MO, Kotecha SJ, Kotecha S
Paediatr Respir Rev 2013 Mar;14(1):29-36; quiz 36-7. Epub 2012 Mar 2 doi: 10.1016/j.prrv.2012.02.002. PMID: 23347658
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962

Clinical prediction guides

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Induction of labour at 41 weeks versus expectant management and induction of labour at 42 weeks (SWEdish Post-term Induction Study, SWEPIS): multicentre, open label, randomised, superiority trial.
Wennerholm UB, Saltvedt S, Wessberg A, Alkmark M, Bergh C, Wendel SB, Fadl H, Jonsson M, Ladfors L, Sengpiel V, Wesström J, Wennergren G, Wikström AK, Elden H, Stephansson O, Hagberg H
BMJ 2019 Nov 20;367:l6131. doi: 10.1136/bmj.l6131. PMID: 31748223Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Recent systematic reviews

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Surfactant for meconium aspiration syndrome in term and late preterm infants.
El Shahed AI, Dargaville PA, Ohlsson A, Soll R
Cochrane Database Syst Rev 2014 Dec 14;2014(12):CD002054. doi: 10.1002/14651858.CD002054.pub3. PMID: 25504256Free PMC Article

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