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Pleomorphic liposarcoma

MedGen UID:
61457
Concept ID:
C0205825
Neoplastic Process
Synonyms: Liposarcoma, Pleomorphic; Pleomorphic Liposarcoma; Pleomorphic Liposarcomas
SNOMED CT: Pleomorphic liposarcoma (404071006); Pleomorphic liposarcoma (112683004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020562
Orphanet: ORPHA99969

Definition

Pleomorphic liposarcoma (PLS), the rarest subtype of liposarcoma (LS; see this term), is an aggressive, fast growing tumor located usually in the deep soft tissues of the lower and upper extremities. It is characterized by a variable number of pleomorphic lipoblasts and, in contrast to dedifferentiated liposarcoma, it lacks any association with well-differentiated liposarcoma (see these terms). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic liposarcoma
Follow this link to review classifications for Pleomorphic liposarcoma in Orphanet.

Professional guidelines

PubMed

Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Dei Tos AP
Histopathology 2014 Jan;64(1):38-52. Epub 2013 Dec 6 doi: 10.1111/his.12311. PMID: 24118009

Diagnosis

Fadaei S, Cordier F, Ferdinande L, Van Dorpe J, Creytens D
Histol Histopathol 2024 Sep;39(9):1101-1108. Epub 2024 Feb 26 doi: 10.14670/HH-18-724. PMID: 38450446
Dermawan JK
Surg Pathol Clin 2024 Mar;17(1):25-29. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.005. PMID: 38278605
Hadjimichael AC, Bekos A, Tsukamoto S, Nitta Y, Righi A, Errani C, Mavrogenis AF
Orthopedics 2023 Mar-Apr;46(2):e72-e80. Epub 2022 Jul 25 doi: 10.3928/01477447-20220719-05. PMID: 35876778
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Therapy

Assi T, Ngo C, Faron M, Verret B, Lévy A, Honoré C, Hénon C, Le Péchoux C, Bahleda R, Le Cesne A
Curr Treat Options Oncol 2023 Nov;24(11):1598-1613. Epub 2023 Oct 16 doi: 10.1007/s11864-023-01139-3. PMID: 37843627
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163
Abbas Manji G, Singer S, Koff A, Schwartz GK
Am Soc Clin Oncol Educ Book 2015:213-8. doi: 10.14694/EdBook_AM.2015.35.213. PMID: 25993159

Prognosis

Fadaei S, Cordier F, Ferdinande L, Van Dorpe J, Creytens D
Histol Histopathol 2024 Sep;39(9):1101-1108. Epub 2024 Feb 26 doi: 10.14670/HH-18-724. PMID: 38450446
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Oliveira AM, Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):274-85. PMID: 11757868

Clinical prediction guides

Creytens D, Folpe AL, Koelsche C, Mentzel T, Ferdinande L, van Gorp JM, Van der Linden M, Raman L, Menten B, Fritchie K, von Deimling A, Van Dorpe J, Flucke U
Mod Pathol 2021 Nov;34(11):2043-2049. Epub 2021 Jun 24 doi: 10.1038/s41379-021-00862-2. PMID: 34168281
Wan L, Tu C, Qi L, Li Z
J Orthop Surg Res 2021 Mar 4;16(1):175. doi: 10.1186/s13018-021-02327-3. PMID: 33663547Free PMC Article
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Cacciatore M, Dei Tos AP
Pathology 2014 Feb;46(2):126-34. doi: 10.1097/PAT.0000000000000063. PMID: 24384587
Ghadimi MP, Liu P, Peng T, Bolshakov S, Young ED, Torres KE, Colombo C, Hoffman A, Broccoli D, Hornick JL, Lazar AJ, Pisters P, Pollock RE, Lev D
Cancer 2011 Dec 1;117(23):5359-69. Epub 2011 May 19 doi: 10.1002/cncr.26195. PMID: 21598240Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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