U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Leiomyomatosis

MedGen UID:
60203
Concept ID:
C0206654
Neoplastic Process
Synonym: Leiomyomatoses
SNOMED CT: Leiomyomatosis (1157154004); Intravascular leiomyomatosis (1157155003)
 
Monarch Initiative: MONDO:0003295

Definition

A condition characterized by the presence of numerous small benign smooth muscle neoplasms located throughout the body. [from NCI]

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Maher ER
World J Urol 2018 Dec;36(12):1891-1898. Epub 2018 Apr 21 doi: 10.1007/s00345-018-2288-5. PMID: 29680948Free PMC Article
Andrici J, Gill AJ, Hornick JL
Semin Diagn Pathol 2018 May;35(3):161-169. Epub 2017 Jun 27 doi: 10.1053/j.semdp.2017.05.004. PMID: 28662997

Recent clinical studies

Etiology

Wilde BR, Chakraborty N, Matulionis N, Hernandez S, Ueno D, Gee ME, Esplin ED, Ouyang K, Nykamp K, Shuch B, Christofk HR
Cancer Discov 2023 Sep 6;13(9):2072-2089. doi: 10.1158/2159-8290.CD-22-0874. PMID: 37255402Free PMC Article
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Levine MS, Buck JL, Pantongrag-Brown L, Buetow PC, Lowry MA, Sobin LH
Radiology 1996 May;199(2):533-6. doi: 10.1148/radiology.199.2.8668807. PMID: 8668807

Diagnosis

Deng Y, Dong S, Song B
Heart Lung Circ 2021 Feb;30(2):240-246. Epub 2020 Aug 21 doi: 10.1016/j.hlc.2020.07.006. PMID: 32830033
Ooi A
Semin Cancer Biol 2020 Apr;61:158-166. Epub 2019 Nov 2 doi: 10.1016/j.semcancer.2019.10.016. PMID: 31689495Free PMC Article
Patel VM, Handler MZ, Schwartz RA, Lambert WC
J Am Acad Dermatol 2017 Jul;77(1):149-158. Epub 2017 Mar 14 doi: 10.1016/j.jaad.2017.01.023. PMID: 28314682
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):589-95. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.019. PMID: 27514603
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218

Therapy

Xu Y, Kong W, Cao M, Wang J, Wang Z, Zheng L, Wu X, Cheng R, He W, Yang B, Dong B, Pan J, Chen Y, Huang J, Jiang C, Zhai W, Li F, Chen R, Zhou X, Wu G, Geng X, Chen J, An H, Yuan Y, Xu T, Chen D, Lin D, Xu L, Huang K, Peng L, Yu Y, Tai S, Qi H, Luo K, Kang X, Wang H, Huang Y, Zhang J, Xue W
Eur Urol 2023 Feb;83(2):163-172. Epub 2022 Jun 15 doi: 10.1016/j.eururo.2022.05.029. PMID: 35715365
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Al-Hendy A, Myers ER, Stewart E
Semin Reprod Med 2017 Nov;35(6):473-480. Epub 2017 Nov 3 doi: 10.1055/s-0037-1607264. PMID: 29100234Free PMC Article
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):589-95. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.019. PMID: 27514603
Amin A, Burgess EF
Semin Oncol 2016 Jun;43(3):408-12. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.016. PMID: 27178696

Prognosis

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Pedrosa AL, Bitencourt L, Paranhos RM, Leitáo CA, Ferreira GC, Simões E Silva AC
Curr Med Chem 2021;28(27):5602-5624. doi: 10.2174/0929867328666210108113500. PMID: 33423643
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):589-95. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.019. PMID: 27514603
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218
Gardie B, Remenieras A, Kattygnarath D, Bombled J, Lefèvre S, Perrier-Trudova V, Rustin P, Barrois M, Slama A, Avril MF, Bessis D, Caron O, Caux F, Collignon P, Coupier I, Cremin C, Dollfus H, Dugast C, Escudier B, Faivre L, Field M, Gilbert-Dussardier B, Janin N, Leport Y, Leroux D, Lipsker D, Malthieu F, McGilliwray B, Maugard C, Méjean A, Mortemousque I, Plessis G, Poppe B, Pruvost-Balland C, Rooker S, Roume J, Soufir N, Steinraths M, Tan MH, Théodore C, Thomas L, Vabres P, Van Glabeke E, Meric JB, Verkarre V, Lenoir G, Joulin V, Deveaux S, Cusin V, Feunteun J, Teh BT, Bressac-de Paillerets B, Richard S; French National Cancer Institute "Inherited predisposition to kidney cancer" network
J Med Genet 2011 Apr;48(4):226-34. Epub 2011 Mar 12 doi: 10.1136/jmg.2010.085068. PMID: 21398687

Clinical prediction guides

Xu Y, Kong W, Cao M, Wang J, Wang Z, Zheng L, Wu X, Cheng R, He W, Yang B, Dong B, Pan J, Chen Y, Huang J, Jiang C, Zhai W, Li F, Chen R, Zhou X, Wu G, Geng X, Chen J, An H, Yuan Y, Xu T, Chen D, Lin D, Xu L, Huang K, Peng L, Yu Y, Tai S, Qi H, Luo K, Kang X, Wang H, Huang Y, Zhang J, Xue W
Eur Urol 2023 Feb;83(2):163-172. Epub 2022 Jun 15 doi: 10.1016/j.eururo.2022.05.029. PMID: 35715365
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Amin A, Burgess EF
Semin Oncol 2016 Jun;43(3):408-12. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.016. PMID: 27178696
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218
Hoynck van Papendrecht HP, Gratama S
Eur J Obstet Gynecol Reprod Biol 1983 Jan;14(4):251-9. doi: 10.1016/0028-2243(83)90268-x. PMID: 6339285

Recent systematic reviews

Lim WH, Lamaro VP, Sivagnanam V
Surg Oncol 2022 Dec;45:101879. Epub 2022 Oct 17 doi: 10.1016/j.suronc.2022.101879. PMID: 36332557
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Lete I, González J, Ugarte L, Barbadillo N, Lapuente O, Álvarez-Sala J
Eur J Obstet Gynecol Reprod Biol 2016 Aug;203:250-9. Epub 2016 Jun 10 doi: 10.1016/j.ejogrb.2016.05.025. PMID: 27359081
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...