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Pleomorphic lipoma

MedGen UID:
60027
•Concept ID:
C0205823
•
Neoplastic Process
Synonyms: Lipoma, Pleomorphic; Lipomas, Pleomorphic; Pleomorphic Lipoma; Pleomorphic Lipomas
SNOMED CT: Pleomorphic lipoma (404059000); Pleomorphic lipoma (21396005)
 
Monarch Initiative: MONDO:0000966

Definition

A benign circumscribed tumor characterized by small spindle cells, rounded hyperchromatic cells and multinucleated giant cells with radially arranged nuclei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic lipoma

Professional guidelines

PubMed

From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications.
Barisella M, Giannini L, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2020 Apr;28(2):136-143. doi: 10.1097/MOO.0000000000000608. PMID: 32011399
MDM2 Amplification in Problematic Lipomatous Tumors: Analysis of FISH Testing Criteria.
Clay MR, Martinez AP, Weiss SW, Edgar MA
Am J Surg Pathol 2015 Oct;39(10):1433-9. doi: 10.1097/PAS.0000000000000468. PMID: 26146760
Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis.
Meis-Kindblom JM, Sjögren H, Kindblom LG, Peydró-Mellquist A, Röijer E, Aman P, Stenman G
Virchows Arch 2001 Aug;439(2):141-51. doi: 10.1007/s004280100423. PMID: 11561754

Recent clinical studies

Etiology

What's new in adipocytic neoplasia?
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279
Atypical lipoma.
Kindblom LG, Angervall L, Fassina AS
Acta Pathol Microbiol Immunol Scand A 1982 Jan;90(1):27-36. doi: 10.1111/j.1699-0463.1982.tb00060_90a.x. PMID: 7080811

Diagnosis

A Case of Nasopharyngeal Pleomorphic Lipoma.
Rao Y, Wang J, Ni X
Laryngoscope 2024 Jun;134(6):2710-2712. Epub 2023 Dec 22 doi: 10.1002/lary.31240. PMID: 38131489
What's new in adipocytic neoplasia?
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
Purely intradermal atypical spindle cell/pleomorphic lipomatous tumor.
Creytens D
J Cutan Pathol 2021 Apr;48(4):601-602. Epub 2020 Aug 26 doi: 10.1111/cup.13731. PMID: 32352578
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall.
Smith SC, Poznanski AA, Fullen DR, Ma L, McHugh JB, Lucas DR, Patel RM
J Cutan Pathol 2013 Jul;40(7):639-45. Epub 2013 Apr 19 doi: 10.1111/cup.12158. PMID: 23600956
Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later.
DeComas AM, Heinrich SD, Craver R
J Pediatr Hematol Oncol 2009 Jun;31(6):448-52. doi: 10.1097/MPH.0b013e3181a1c0c4. PMID: 19648795
Sclerotic (fibroma-like) lipoma: a distinctive lipoma variant with a predilection for the distal extremities.
Laskin WB, Fetsch JF, Michal M, Miettinen M
Am J Dermatopathol 2006 Aug;28(4):308-16. doi: 10.1097/00000372-200608000-00003. PMID: 16871033

Prognosis

What's new in adipocytic neoplasia?
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279
Atypical lipoma.
Kindblom LG, Angervall L, Fassina AS
Acta Pathol Microbiol Immunol Scand A 1982 Jan;90(1):27-36. doi: 10.1111/j.1699-0463.1982.tb00060_90a.x. PMID: 7080811

Clinical prediction guides

Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?
Kilpatrick SE
Hum Pathol 2024 May;147:82-91. Epub 2023 Dec 21 doi: 10.1016/j.humpath.2023.12.005. PMID: 38135062
Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT): A report of three FNA cases and comparison with spindle cell/pleomorphic lipoma cytopathology.
Wakely PE Jr
Cytopathology 2023 Jul;34(4):346-352. Epub 2023 Mar 17 doi: 10.1111/cyt.13227. PMID: 36856555
Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Lipoblasts in spindle cell and pleomorphic lipomas: a close scrutiny.
Michal M, Kazakov DV, Hadravsky L, Michalova K, Grossmann P, Steiner P, Vanecek T, Renda V, Suster S, Michal M
Hum Pathol 2017 Jul;65:140-146. Epub 2017 May 23 doi: 10.1016/j.humpath.2017.05.006. PMID: 28546131

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