U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Idiopathic anaphylaxis

MedGen UID:
595022
Concept ID:
C0413235
Disease or Syndrome
Synonyms: idiopathic anaphylaxis; Syndrome of idiopathic anaphylaxis
SNOMED CT: Idiopathic anaphylaxis (241954008); Syndrome of idiopathic anaphylaxis (241954008)
 
HPO: HP:0410148
Monarch Initiative: MONDO:0100054

Definition

A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic anaphylaxis

Professional guidelines

PubMed

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Burrows AG, Ellis AK
Allergy Asthma Proc 2021 Nov 1;42(6):481-488. doi: 10.2500/aap.2021.42.210081. PMID: 34871155

Recent clinical studies

Etiology

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article
Schuch A, Brockow K
Immunol Allergy Clin North Am 2017 Feb;37(1):153-164. Epub 2016 Oct 28 doi: 10.1016/j.iac.2016.08.017. PMID: 27886904

Diagnosis

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Guo C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):457-461. doi: 10.2500/aap.2019.40.4271. PMID: 31690394
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article

Therapy

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Guo C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):457-461. doi: 10.2500/aap.2019.40.4271. PMID: 31690394
Greenberger PA, Lieberman P
J Allergy Clin Immunol Pract 2014 May-Jun;2(3):243-50; quiz 251. Epub 2014 Apr 6 doi: 10.1016/j.jaip.2014.02.012. PMID: 24811012

Prognosis

Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Bilò MB, Martini M, Tontini C, Mohamed OE, Krishna MT
Clin Exp Allergy 2019 Jul;49(7):942-952. Epub 2019 May 13 doi: 10.1111/cea.13402. PMID: 31002196
Fenny N, Grammer LC
Immunol Allergy Clin North Am 2015 May;35(2):349-62. Epub 2015 Mar 6 doi: 10.1016/j.iac.2015.01.004. PMID: 25841556
Lieberman PL
Allergy Asthma Proc 2014 Jan-Feb;35(1):17-23. doi: 10.2500/aap.2014.35.3717. PMID: 24433593
Patterson R, Harris KE
Allergy Asthma Proc 1999 Sep-Oct;20(5):311-5. doi: 10.2500/108854199778251906. PMID: 10566101

Clinical prediction guides

Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Wallace DV
Ann Allergy Asthma Immunol 2023 Aug;131(2):151-169. Epub 2023 May 19 doi: 10.1016/j.anai.2023.05.010. PMID: 37209836
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Commins SP, Jerath MR, Cox K, Erickson LD, Platts-Mills T
Allergol Int 2016 Jan;65(1):16-20. Epub 2015 Nov 21 doi: 10.1016/j.alit.2015.10.001. PMID: 26666477Free PMC Article

Recent systematic reviews

Kaminsky LW, Aukstuolis K, Petroni DH, Al-Shaikhly T
Ann Allergy Asthma Immunol 2021 Oct;127(4):481-487. Epub 2021 Jun 24 doi: 10.1016/j.anai.2021.06.017. PMID: 34175498
Jendoubi F, Gaudenzio N, Gallini A, Negretto M, Paul C, Bulai Livideanu C
Clin Exp Allergy 2020 Jun;50(6):654-661. Epub 2020 Mar 25 doi: 10.1111/cea.13592. PMID: 32107810

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...