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Fetal acidosis

MedGen UID:
593455
•Concept ID:
C0410959
•
Disease or Syndrome
Synonyms: Fetal Acidemia; Fetal Acidosis; Foetal acidosis
SNOMED CT: Foetal acidosis (240306004); Fetal acidosis (240306004)

Definition

An abnormally high hydrogen ion concentration (umbilical arterial blood pH less than 7.00) in fetal blood or tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal acidosis

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Terbutaline in the management of acute intrapartum fetal acidosis.
Tejani NA, Verma UL, Chatterjee S, Mittelmann S
J Reprod Med 1983 Dec;28(12):857-61. PMID: 6663586

Recent clinical studies

Etiology

Non-obstetric Acute Abdomen in Pregnancy: a Review of Literature.
Alsadery HA, Bamalan OA, Aljubran HJ, Albaish LJ, Al Ghanim BZ
Med Arch 2023;77(4):293-298. doi: 10.5455/medarh.2023.77.293-298. PMID: 37876566Free PMC Article
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438
Nonobstetric anesthesia during pregnancy.
Heesen M, Klimek M
Curr Opin Anaesthesiol 2016 Jun;29(3):297-303. doi: 10.1097/ACO.0000000000000311. PMID: 26859466

Diagnosis

Non-obstetric Acute Abdomen in Pregnancy: a Review of Literature.
Alsadery HA, Bamalan OA, Aljubran HJ, Albaish LJ, Al Ghanim BZ
Med Arch 2023;77(4):293-298. doi: 10.5455/medarh.2023.77.293-298. PMID: 37876566Free PMC Article
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Causes and consequences of fetal acidosis.
Bobrow CS, Soothill PW
Arch Dis Child Fetal Neonatal Ed 1999 May;80(3):F246-9. doi: 10.1136/fn.80.3.f246. PMID: 10212094Free PMC Article
Prevention and correction of fetal acidosis and hypoxia.
Seeds AE, Escarcena L
Clin Obstet Gynecol 1974 Sep;17(3):115-34. doi: 10.1097/00003081-197409000-00008. PMID: 4606933

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Association Between Obesity and Fetal Acidosis at Scheduled Cesarean Delivery.
DeBolt CA, Sarker M, Trejo FE, Feldman K, Kaplowitz E, Rattner P, Paul K, Jagannatham S, Ferrara L, Doulaveris G, Bernstein PS, Brustman L, Glazer KB, Stone J, Bianco A
Obstet Gynecol 2022 Dec 1;140(6):950-957. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004968. PMID: 36357997
Nonobstetric anesthesia during pregnancy.
Heesen M, Klimek M
Curr Opin Anaesthesiol 2016 Jun;29(3):297-303. doi: 10.1097/ACO.0000000000000311. PMID: 26859466
The administration of analgesics.
Carson R
Mod Midwife 1996 Nov;6(11):12-6. PMID: 9052149
Prevention and correction of fetal acidosis and hypoxia.
Seeds AE, Escarcena L
Clin Obstet Gynecol 1974 Sep;17(3):115-34. doi: 10.1097/00003081-197409000-00008. PMID: 4606933

Prognosis

Improving the interpretation of electronic fetal monitoring: the fetal reserve index.
Evans MI, Britt DW, Evans SM, Devoe LD
Am J Obstet Gynecol 2023 May;228(5S):S1129-S1143. Epub 2023 Mar 17 doi: 10.1016/j.ajog.2022.11.1275. PMID: 37164491
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.
Allanson ER, Waqar T, White C, Tunçalp Ö, Dickinson JE
BJOG 2017 Mar;124(4):584-594. Epub 2016 Oct 5 doi: 10.1111/1471-0528.14306. PMID: 27704703
Fetal pulse oximetry.
Luttkus AK, Dudenhausen JW
Curr Opin Obstet Gynecol 1998 Dec;10(6):481-6. doi: 10.1097/00001703-199812000-00009. PMID: 9866017

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Association Between Obesity and Fetal Acidosis at Scheduled Cesarean Delivery.
DeBolt CA, Sarker M, Trejo FE, Feldman K, Kaplowitz E, Rattner P, Paul K, Jagannatham S, Ferrara L, Doulaveris G, Bernstein PS, Brustman L, Glazer KB, Stone J, Bianco A
Obstet Gynecol 2022 Dec 1;140(6):950-957. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004968. PMID: 36357997
Prediction of obstetrical and fetal complications using automated electronic health record data.
Escobar GJ, Soltesz L, Schuler A, Niki H, Malenica I, Lee C
Am J Obstet Gynecol 2021 Feb;224(2):137-147.e7. Epub 2020 Oct 22 doi: 10.1016/j.ajog.2020.10.030. PMID: 33098815
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438

Recent systematic reviews

Comparison of Phenylephrine Bolus and Infusion Regimens on Maternal and Fetal Outcomes During Cesarean Delivery: A Systematic Review and Meta-Analysis.
Garg H, Narayanan M R V, Khanna P, Yalla B
Anesth Analg 2024 Dec 1;139(6):1144-1155. Epub 2024 Nov 15 doi: 10.1213/ANE.0000000000007156. PMID: 39715512
Norepinephrine versus phenylephrine for postspinal hypotension in parturients undergoing cesarean section: a systematic review and meta-analysis.
Kumari K, Chaudhary K, Sethi P, Rathod D, Meshram T, Kothari N, Sharma A, Bhatia P, Singh S
Minerva Anestesiol 2022 Dec;88(12):1043-1056. Epub 2022 Jul 5 doi: 10.23736/S0375-9393.22.16654-X. PMID: 35785931
A systematic review of phenylephrine vs. noradrenaline for the management of hypotension associated with neuraxial anaesthesia in women undergoing caesarean section.
Heesen M, Hilber N, Rijs K, Rossaint R, Girard T, Mercier FJ, Klimek M
Anaesthesia 2020 Jun;75(6):800-808. Epub 2020 Feb 3 doi: 10.1111/anae.14976. PMID: 32012226
Regimens of ultrasound surveillance for twin pregnancies for improving outcomes.
Woolcock JG, Grivell RM, Dodd JM
Cochrane Database Syst Rev 2017 Nov 7;11(11):CD011371. doi: 10.1002/14651858.CD011371.pub2. PMID: 29108135Free PMC Article
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.
Allanson ER, Waqar T, White C, Tunçalp Ö, Dickinson JE
BJOG 2017 Mar;124(4):584-594. Epub 2016 Oct 5 doi: 10.1111/1471-0528.14306. PMID: 27704703

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