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Centrifugal lipodystrophy

MedGen UID:
590539
Concept ID:
C0406605
Disease or Syndrome
Synonyms: centrifugal lipodystrophy; Lipodystrophia centrifugalis abdominalis infantalis; Lipodystrophia centrifugalis abdominalis infantilis; lipodystrophia centrifugalis abdominalis infantilis
SNOMED CT: Lipodystrophia centrifugalis abdominalis infantalis (238899009)
 
Monarch Initiative: MONDO:0019552
Orphanet: ORPHA90156

Definition

Centrifugal lipodystrophy is a rare, acquired, localized lipodistrophy characterized by single or, occasionally, multiple, centrifugally progressive, asymptomatic to sometimes mildly tender, hypopigmented, lipoatrophic skin depressions with weakly erymatheous inflammatory borders, typically associated with regional ipsilateral lymph nodes swelling. Lesions typically occur on lower trunk (in particular groin and abdomen region), followed by upper trunk (axilla and neighboring regions) and, rarely, neck and head. It is usually not associated with systemic disease and is typically self-resolving. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentrifugal lipodystrophy

Professional guidelines

PubMed

Serra-Renom JM, Fontdevila J
Plast Reconstr Surg 2004 Aug;114(2):551-5; discussion 556-7. doi: 10.1097/01.prs.0000128427.54445.63. PMID: 15277830

Recent clinical studies

Etiology

Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199

Diagnosis

Xu Q, Qiu Y, Lu Z, Yu H, Ling B, Li Y, Gu Y, Yao Z
Dermatol Ther 2022 Nov;35(11):e15825. Epub 2022 Sep 27 doi: 10.1111/dth.15825. PMID: 36100983
Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199
Hagari Y, Ikehara A, Nuno K, Mihara M
Cutis 2002 Apr;69(4):281-3. PMID: 12080947

Therapy

Xu Q, Qiu Y, Lu Z, Yu H, Ling B, Li Y, Gu Y, Yao Z
Dermatol Ther 2022 Nov;35(11):e15825. Epub 2022 Sep 27 doi: 10.1111/dth.15825. PMID: 36100983

Prognosis

Xu Q, Qiu Y, Lu Z, Yu H, Ling B, Li Y, Gu Y, Yao Z
Dermatol Ther 2022 Nov;35(11):e15825. Epub 2022 Sep 27 doi: 10.1111/dth.15825. PMID: 36100983
Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199

Clinical prediction guides

Harada K, Maeda T, Matsubayashi J, Uchiyama M, Irisawa R, Go K, Tsuboi R
Clin Exp Dermatol 2018 Apr;43(3):286-290. Epub 2017 Dec 20 doi: 10.1111/ced.13328. PMID: 29266423
Fukumoto D, Kubo Y, Saito M, Arase S
J Dermatol 2009 Sep;36(9):499-503. doi: 10.1111/j.1346-8138.2009.00685.x. PMID: 19712277

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