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Leukemic infiltration

MedGen UID:
58150
•Concept ID:
C0162679
•
Neoplastic Process
Synonyms: Infiltration, Leukemic; Infiltrations, Leukemic; Leukemic Infiltration; Leukemic Infiltrations
SNOMED CT: Leukemic infiltration (446688004)

Definition

A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemic infiltration

Professional guidelines

PubMed

Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.
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Leuk Lymphoma 2010 Jun;51(6):1063-71. doi: 10.3109/10428191003754608. PMID: 20470218
Acute leukemia: diagnosis and management of testicular involvement.
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Electrolyte and acid-base disturbances in the management of leukemia.
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Blood 1977 Mar;49(3):345-53. PMID: 264790

Recent clinical studies

Etiology

Different tools for the diagnosis and molecular follow-up of leukemias and lymphomas.
Sayagués JM, Sarasquete ME
Med Clin (Barc) 2018 Mar 9;150(5):202-203. Epub 2017 Nov 20 doi: 10.1016/j.medcli.2017.10.012. PMID: 29162275
Central nervous involvement by chronic lymphocytic leukaemia.
Szczepanek D, Wąsik-Szczepanek E, Szymczyk A, Wach M, Cioch M, Podhorecka M, Grywalska E, Hus M
Neurol Neurochir Pol 2018 Mar;52(2):228-234. Epub 2017 Nov 1 doi: 10.1016/j.pjnns.2017.10.012. PMID: 29146406
Therapy-related leukaemia cutis: a review.
Weinel S, Malone J, Jain D, Callen JP
Australas J Dermatol 2008 Nov;49(4):187-90. doi: 10.1111/j.1440-0960.2008.00466.x. PMID: 18855778
Burkitt's acute lymphocytic leukemia (L3ALL) in adults.
Fenaux P, Bourhis JH, Ribrag V
Hematol Oncol Clin North Am 2001 Feb;15(1):37-50. doi: 10.1016/s0889-8588(05)70199-4. PMID: 11253608
Treatment of childhood leukemia.
Silverman LB, Weinstein HJ
Curr Opin Oncol 1997 Jan;9(1):26-33. doi: 10.1097/00001622-199701000-00005. PMID: 9090491

Diagnosis

Different tools for the diagnosis and molecular follow-up of leukemias and lymphomas.
Sayagués JM, Sarasquete ME
Med Clin (Barc) 2018 Mar 9;150(5):202-203. Epub 2017 Nov 20 doi: 10.1016/j.medcli.2017.10.012. PMID: 29162275
Leukaemia cutis.
Kumar N, Yadav S, Reddy V, Robert F
Lancet 2012 Sep 29;380(9848):1179. Epub 2012 Jun 15 doi: 10.1016/S0140-6736(12)60352-3. PMID: 22704804
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Leukemia cutis.
Cho-Vega JH, Medeiros LJ, Prieto VG, Vega F
Am J Clin Pathol 2008 Jan;129(1):130-42. doi: 10.1309/WYACYWF6NGM3WBRT. PMID: 18089498
Neurolymphomatosis.
Baehring J, Cooper D
J Neurooncol 2004 Jul;68(3):243-4. doi: 10.1023/b:neon.0000033496.29296.a7. PMID: 15332327

Therapy

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
CART attack.
Pillai V, Maude SL
Blood 2017 Jul 13;130(2):229. doi: 10.1182/blood-2017-04-779009. PMID: 28705860
New agents for intrathecal administration.
Stapleton S, Blaney S
Cancer Invest 2006 Aug-Sep;24(5):528-34. doi: 10.1080/07357900600815166. PMID: 16939963
Intrathecal chemotherapy.
Kerr JZ, Berg S, Blaney SM
Crit Rev Oncol Hematol 2001 Mar;37(3):227-36. doi: 10.1016/s1040-8428(00)00115-3. PMID: 11248578
Treatment of childhood leukemia.
Silverman LB, Weinstein HJ
Curr Opin Oncol 1997 Jan;9(1):26-33. doi: 10.1097/00001622-199701000-00005. PMID: 9090491

Prognosis

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Post-bone-marrow-transplant leukemia cutis.
Pulgar F, Vélez D, Valdeolivas N, García J, Cabrera A, Pericet L, Trasobares L, Medina S, García M
Dermatol Online J 2013 Feb 15;19(2):6. PMID: 23473276
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
The leukemias.
Burke VP, Startzell JM
Oral Maxillofac Surg Clin North Am 2008 Nov;20(4):597-608. doi: 10.1016/j.coms.2008.06.011. PMID: 18940626
Leukemia cutis.
Ratnam KV, Khor CJ, Su WP
Dermatol Clin 1994 Apr;12(2):419-31. PMID: 8045053

Clinical prediction guides

Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche.
Chen DW, Fan JM, Schrey JM, Mitchell DV, Jung SK, Hurwitz SN, Perez EB, Muraro MJ, Carroll M, Taylor DM, Kurre P
Leukemia 2024 Apr;38(4):741-750. Epub 2024 Jan 16 doi: 10.1038/s41375-024-02136-7. PMID: 38228679Free PMC Article
PD-1/PD-L1 expression in extra-medullary lesions of multiple myeloma.
Crescenzi A, Annibali O, Bianchi A, Pagano A, Donati M, Grifoni A, Avvisati G
Leuk Res 2016 Oct;49:98-101. Epub 2016 Sep 5 doi: 10.1016/j.leukres.2016.09.008. PMID: 27619200
Development and function of human innate immune cells in a humanized mouse model.
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA
Nat Biotechnol 2014 Apr;32(4):364-72. Epub 2014 Mar 16 doi: 10.1038/nbt.2858. PMID: 24633240Free PMC Article
Blueberry muffin baby: a pictoral differential diagnosis.
Mehta V, Balachandran C, Lonikar V
Dermatol Online J 2008 Feb 28;14(2):8. PMID: 18700111
Leukemic children: clinical and histopathological gingival lesions.
Genc A, Atalay T, Gedikoglu G, Zulfikar B, Kullu S
J Clin Pediatr Dent 1998 Spring;22(3):253-6. PMID: 9641103

Recent systematic reviews

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review.
Gomes NR, Lima LA, Morais-Perdigão AL, de Caceres CVBL, Sant'Ana MSP, Pontes HAR, Pontes FSC, Smit C, van Heerden WFP, Robinson L, Brasileiro CB, Brennan PA, Fonseca FP
J Oral Pathol Med 2023 Apr;52(4):315-323. Epub 2023 Mar 7 doi: 10.1111/jop.13422. PMID: 36852531
Purging of malignant cell contamination prior to spermatogonia stem cell autotransplantation to preserve fertility: progress & prospects.
Abdelaal O, Barber H, Atala A, Sadri-Ardekani H
Curr Opin Endocrinol Diabetes Obes 2019 Jun;26(3):166-174. doi: 10.1097/MED.0000000000000481. PMID: 30998603
Anterior segment infiltration of acute lymphoblastic leukemia: case report and systematic review.
Yu AM, Chan SC, Iordanous Y, Padmore RF, O'Connor MD
Can J Ophthalmol 2019 Feb;54(1):20-26. Epub 2018 Apr 22 doi: 10.1016/j.jcjo.2018.02.016. PMID: 30851770

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