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Benign neoplasm of parathyroid gland

MedGen UID:
57814
•Concept ID:
C0154041
•
Neoplastic Process
Synonyms: Benign Neoplasm of Parathyroid; benign neoplasm of parathyroid; Benign Neoplasm of Parathyroid Gland; benign neoplasm of parathyroid gland; Benign Neoplasm of the Parathyroid; benign neoplasm of the parathyroid; Benign Neoplasm of the Parathyroid Gland; benign neoplasm of the parathyroid gland; Benign Parathyroid Gland Neoplasm; benign parathyroid gland neoplasm; Benign Parathyroid Gland Tumor; benign parathyroid gland tumor; benign parathyroid gland tumour; Benign Parathyroid Neoplasm; benign parathyroid neoplasm; Benign Parathyroid Tumor; benign parathyroid tumor; benign parathyroid tumour; Benign Tumor of Parathyroid; benign tumor of parathyroid; Benign tumor of parathyroid gland; Benign Tumor of Parathyroid Gland; benign tumor of parathyroid gland; Benign Tumor of the Parathyroid; benign tumor of the parathyroid; Benign Tumor of the Parathyroid Gland; benign tumor of the parathyroid gland; benign tumour of parathyroid; benign tumour of parathyroid gland; benign tumour of the parathyroid; benign tumour of the parathyroid gland; parathyroid gland benign neoplasm; Parathyroid Tumor Benign; parathyroid tumor benign; parathyroid tumour benign
SNOMED CT: Benign tumor of parathyroid gland (92272009); Benign neoplasm of parathyroid gland (92272009)
 
Monarch Initiative: MONDO:0021463

Definition

A neoplasm that arises from the parathyroid glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of parathyroid gland

Professional guidelines

PubMed

Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines.
Mitchell AL, Gandhi A, Scott-Coombes D, Perros P
J Laryngol Otol 2016 May;130(S2):S150-S160. doi: 10.1017/S0022215116000578. PMID: 27841128Free PMC Article
Primary hyperparathyroidism.
Felger EA, Kandil E
Otolaryngol Clin North Am 2010 Apr;43(2):417-32, x. doi: 10.1016/j.otc.2010.01.009. PMID: 20510724
Thyroid and parathyroid glands: imaging, treatment and beyond. Preface.
Loevner LA
Neuroimaging Clin N Am 2008 Aug;18(3):xiii-xiv. doi: 10.1016/j.nic.2008.06.001. PMID: 18656026

Recent clinical studies

Etiology

Surgery for primary hyperparathyroidism.
das Neves MC, Santos RO, Ohe MN
Arch Endocrinol Metab 2022 Nov 11;66(5):678-688. doi: 10.20945/2359-3997000000557. PMID: 36382757Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Imaging of the thyroid and parathyroid glands.
Vazquez BJ, Richards ML
Surg Clin North Am 2011 Feb;91(1):15-32. doi: 10.1016/j.suc.2010.10.015. PMID: 21184899
Surgery for thyroid cancer.
Gil Z, Patel SG
Surg Oncol Clin N Am 2008 Jan;17(1):93-120, viii. doi: 10.1016/j.soc.2007.10.014. PMID: 18177802Free PMC Article

Diagnosis

Parathyroid Imaging.
Lalonde MN, Correia RD, Syktiotis GP, Schaefer N, Matter M, Prior JO
Semin Nucl Med 2023 Jul;53(4):490-502. Epub 2023 Mar 14 doi: 10.1053/j.semnuclmed.2023.02.004. PMID: 36922339
Parathyroid Pathology.
Guilmette J, Sadow PM
Surg Pathol Clin 2019 Dec;12(4):1007-1019. Epub 2019 Sep 27 doi: 10.1016/j.path.2019.08.006. PMID: 31672291Free PMC Article
Surgery for primary hyperparathyroidism.
Callender GG, Udelsman R
Cancer 2014 Dec 1;120(23):3602-16. Epub 2014 Jul 9 doi: 10.1002/cncr.28891. PMID: 25042934
Parathyroid imaging.
Fakhran S, Branstetter BF 4th, Pryma DA
Neuroimaging Clin N Am 2008 Aug;18(3):537-49, ix. doi: 10.1016/j.nic.2008.03.006. PMID: 18656034
Primary hyperparathyroidism.
Rodgers SE, Lew JI, Solórzano CC
Curr Opin Oncol 2008 Jan;20(1):52-8. doi: 10.1097/CCO.0b013e3282f2838f. PMID: 18043256

Therapy

Surgery for primary hyperparathyroidism.
das Neves MC, Santos RO, Ohe MN
Arch Endocrinol Metab 2022 Nov 11;66(5):678-688. doi: 10.20945/2359-3997000000557. PMID: 36382757Free PMC Article
Lithium-associated hyperparathyroidism.
Mifsud S, Cilia K, Mifsud EL, Gruppetta M
Br J Hosp Med (Lond) 2020 Nov 2;81(11):1-9. Epub 2020 Nov 17 doi: 10.12968/hmed.2020.0457. PMID: 33263481
Atypical parathyroid adenoma.
Ramaswamy AS, Vijitha T, Kumarguru BN, Mahalingashetti PB
Indian J Pathol Microbiol 2017 Jan-Mar;60(1):99-101. doi: 10.4103/0377-4929.200055. PMID: 28195102
Cinacalcet hydrochloride.
Barman Balfour JA, Scott LJ
Drugs 2005;65(2):271-81. doi: 10.2165/00003495-200565020-00007. PMID: 15631545
Parathyroid carcinoma.
Kebebew E
Curr Treat Options Oncol 2001 Aug;2(4):347-54. doi: 10.1007/s11864-001-0028-2. PMID: 12057115

Prognosis

Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Parathyroid carcinoma.
Kebebew E
Curr Treat Options Oncol 2001 Aug;2(4):347-54. doi: 10.1007/s11864-001-0028-2. PMID: 12057115
Sestamibi parathyroid imaging.
McBiles M, Lambert AT, Cote MG, Kim SY
Semin Nucl Med 1995 Jul;25(3):221-34. doi: 10.1016/s0001-2998(95)80012-3. PMID: 7570042

Clinical prediction guides

Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Parathyroid surgery: from inception to the modern day.
Sethi N, England RJA
Br J Hosp Med (Lond) 2017 Jun 2;78(6):333-337. doi: 10.12968/hmed.2017.78.6.333. PMID: 28614027
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Sestamibi parathyroid imaging.
McBiles M, Lambert AT, Cote MG, Kim SY
Semin Nucl Med 1995 Jul;25(3):221-34. doi: 10.1016/s0001-2998(95)80012-3. PMID: 7570042
Parathyroid cytopathology.
Davey DD, Glant MD, Berger EK
Diagn Cytopathol 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116. PMID: 2424691

Recent systematic reviews

Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
A Systematic Review of the Methods of Diagnostic Accuracy Studies of the Afirma Gene Expression Classifier.
Duh QY, Busaidy NL, Rahilly-Tierney C, Gharib H, Randolph G
Thyroid 2017 Oct;27(10):1215-1222. Epub 2017 Aug 17 doi: 10.1089/thy.2016.0656. PMID: 28741442
Diagnostic performance of computed tomography for parathyroid adenoma localization; a systematic review and meta-analysis.
Kluijfhout WP, Pasternak JD, Beninato T, Drake FT, Gosnell JE, Shen WT, Duh QY, Allen IE, Vriens MR, de Keizer B, Hope TA, Suh I
Eur J Radiol 2017 Mar;88:117-128. Epub 2017 Jan 5 doi: 10.1016/j.ejrad.2017.01.004. PMID: 28189196
Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.
Faggiano A, Malandrino P, Modica R, Agrimi D, Aversano M, Bassi V, Giordano EA, Guarnotta V, Logoluso FA, Messina E, Nicastro V, Nuzzo V, Sciaraffia M, Colao A
Oncologist 2016 Jul;21(7):875-86. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0420. PMID: 27053503Free PMC Article
Reoperation for recurrent/persistent well-differentiated thyroid cancer.
Pai SI, Tufano RP
Otolaryngol Clin North Am 2010 Apr;43(2):353-63, ix. doi: 10.1016/j.otc.2010.02.004. PMID: 20510718

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