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Benign neoplasm of parathyroid gland

MedGen UID:
57814
•Concept ID:
C0154041
•
Neoplastic Process
Synonyms: Benign Neoplasm of Parathyroid; benign neoplasm of parathyroid; Benign Neoplasm of Parathyroid Gland; benign neoplasm of parathyroid gland; Benign Neoplasm of the Parathyroid; benign neoplasm of the parathyroid; Benign Neoplasm of the Parathyroid Gland; benign neoplasm of the parathyroid gland; Benign Parathyroid Gland Neoplasm; benign parathyroid gland neoplasm; Benign Parathyroid Gland Tumor; benign parathyroid gland tumor; benign parathyroid gland tumour; Benign Parathyroid Neoplasm; benign parathyroid neoplasm; Benign Parathyroid Tumor; benign parathyroid tumor; benign parathyroid tumour; Benign Tumor of Parathyroid; benign tumor of parathyroid; Benign tumor of parathyroid gland; Benign Tumor of Parathyroid Gland; benign tumor of parathyroid gland; Benign Tumor of the Parathyroid; benign tumor of the parathyroid; Benign Tumor of the Parathyroid Gland; benign tumor of the parathyroid gland; benign tumour of parathyroid; benign tumour of parathyroid gland; benign tumour of the parathyroid; benign tumour of the parathyroid gland; parathyroid gland benign neoplasm; Parathyroid Tumor Benign; parathyroid tumor benign; parathyroid tumour benign
SNOMED CT: Benign tumor of parathyroid gland (92272009); Benign neoplasm of parathyroid gland (92272009)
 
Monarch Initiative: MONDO:0021463

Definition

A neoplasm that arises from the parathyroid glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of parathyroid gland

Professional guidelines

PubMed

Thyroid and parathyroid glands.
Tamaki Y, Ikeda Y, Usui Y, Okamura R, Kitamura K, Kazuo S, Tangoku A
Asian J Endosc Surg 2015 Nov;8(4):379-81. doi: 10.1111/ases.12264. PMID: 26708581
Primary hyperparathyroidism.
Felger EA, Kandil E
Otolaryngol Clin North Am 2010 Apr;43(2):417-32, x. doi: 10.1016/j.otc.2010.01.009. PMID: 20510724
Thyroid and parathyroid glands: imaging, treatment and beyond. Preface.
Loevner LA
Neuroimaging Clin N Am 2008 Aug;18(3):xiii-xiv. doi: 10.1016/j.nic.2008.06.001. PMID: 18656026

Recent clinical studies

Etiology

Surgery for primary hyperparathyroidism.
das Neves MC, Santos RO, Ohe MN
Arch Endocrinol Metab 2022 Nov 11;66(5):678-688. doi: 10.20945/2359-3997000000557. PMID: 36382757Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
The use of near-infrared fluorescence imaging in endocrine surgical procedures.
Kahramangil B, Berber E
J Surg Oncol 2017 Jun;115(7):848-855. Epub 2017 Feb 15 doi: 10.1002/jso.24583. PMID: 28205245
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Parathyroid localization using 4D-computed tomography.
Bann DV, Zacharia T, Goldenberg D, Goyal N
Ear Nose Throat J 2015 Apr-May;94(4-5):E55-7. doi: 10.1177/014556131509404-506. PMID: 25923289Free PMC Article

Diagnosis

Parathyroid Imaging.
Lalonde MN, Correia RD, Syktiotis GP, Schaefer N, Matter M, Prior JO
Semin Nucl Med 2023 Jul;53(4):490-502. Epub 2023 Mar 14 doi: 10.1053/j.semnuclmed.2023.02.004. PMID: 36922339
A review of parathyroid mass and patients with nonspecific complaints.
Demir AD
J Int Med Res 2020 Jan;48(1):300060519827169. Epub 2019 Feb 21 doi: 10.1177/0300060519827169. PMID: 30791798Free PMC Article
Parathyroid Pathology.
Guilmette J, Sadow PM
Surg Pathol Clin 2019 Dec;12(4):1007-1019. Epub 2019 Sep 27 doi: 10.1016/j.path.2019.08.006. PMID: 31672291Free PMC Article
Parathyromatosis and parathyroid cancer.
Shen WT
Cancer Treat Res 2010;153:105-16. doi: 10.1007/978-1-4419-0857-5_7. PMID: 19957222
Primary hyperparathyroidism.
Rodgers SE, Lew JI, Solórzano CC
Curr Opin Oncol 2008 Jan;20(1):52-8. doi: 10.1097/CCO.0b013e3282f2838f. PMID: 18043256

Therapy

Lithium-associated hyperparathyroidism.
Mifsud S, Cilia K, Mifsud EL, Gruppetta M
Br J Hosp Med (Lond) 2020 Nov 2;81(11):1-9. Epub 2020 Nov 17 doi: 10.12968/hmed.2020.0457. PMID: 33263481
Parathyroid tumors.
Granberg PO, Cedermark B, Farnebo LO, Hamberger B, Werner S
Curr Probl Cancer 1985 Nov;9(11):1-52. doi: 10.1016/s0147-0272(85)80035-0. PMID: 3905268
Primary immunodeficiency.
Rosen FS
Pediatr Clin North Am 1974 Aug;21(3):533-49. doi: 10.1016/s0031-3955(16)33023-1. PMID: 4137895
Clinical applications of radioimmunoassay of plasma parathyroid hormone.
Berson SA, Yalow RS
Am J Med 1971 May;50(5):623-9. doi: 10.1016/0002-9343(71)90117-3. PMID: 4930270
The clinical physiology of calcium homeostasis, parathyroid hormone, and calcitonin. II.
Kleeman CR, Massry SG, Coburn JW
Calif Med 1971 Apr;114(4):19-30. PMID: 4927915Free PMC Article

Prognosis

Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Parathyromatosis and parathyroid cancer.
Shen WT
Cancer Treat Res 2010;153:105-16. doi: 10.1007/978-1-4419-0857-5_7. PMID: 19957222
Parathyroid carcinoma.
Kebebew E
Curr Treat Options Oncol 2001 Aug;2(4):347-54. doi: 10.1007/s11864-001-0028-2. PMID: 12057115
Parathyroid tumors.
Granberg PO, Cedermark B, Farnebo LO, Hamberger B, Werner S
Curr Probl Cancer 1985 Nov;9(11):1-52. doi: 10.1016/s0147-0272(85)80035-0. PMID: 3905268

Clinical prediction guides

Use of Vascular Clues to Locate Ectopic Parathyroid Glands and Predict Anatomic Abnormalities.
Battista RA, Noel JE, Orloff LA
JAMA Otolaryngol Head Neck Surg 2021 Feb 1;147(2):211-213. doi: 10.1001/jamaoto.2020.3749. PMID: 33090209
The use of near-infrared fluorescence imaging in endocrine surgical procedures.
Kahramangil B, Berber E
J Surg Oncol 2017 Jun;115(7):848-855. Epub 2017 Feb 15 doi: 10.1002/jso.24583. PMID: 28205245
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Sestamibi parathyroid imaging.
McBiles M, Lambert AT, Cote MG, Kim SY
Semin Nucl Med 1995 Jul;25(3):221-34. doi: 10.1016/s0001-2998(95)80012-3. PMID: 7570042
Parathyroid cytopathology.
Davey DD, Glant MD, Berger EK
Diagn Cytopathol 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116. PMID: 2424691

Recent systematic reviews

Parathyroid Cystic Adenoma: A Systematic Review and Meta-Analysis.
Daoud A, Ronen O
Endocr Pract 2023 Jan;29(1):2-10. Epub 2022 Nov 10 doi: 10.1016/j.eprac.2022.11.004. PMID: 36370985
Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
Assessment and Comparison of (18)F-Fluorocholine PET and (99m)Tc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis.
Whitman J, Allen IE, Bergsland EK, Suh I, Hope TA
J Nucl Med 2021 Sep 1;62(9):1285-1291. Epub 2021 Jan 15 doi: 10.2967/jnumed.120.257303. PMID: 33452040Free PMC Article
Vitamin D Receptor Polymorphisms and Cancer.
Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, Gandini S
Adv Exp Med Biol 2020;1268:53-114. doi: 10.1007/978-3-030-46227-7_4. PMID: 32918214
Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review.
Gebauer J, Higham C, Langer T, Denzer C, Brabant G
Endocr Rev 2019 Jun 1;40(3):711-767. doi: 10.1210/er.2018-00092. PMID: 30476004

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