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Metastatic Malignant Neoplasm in the Lung

MedGen UID:
57798
Concept ID:
C0153676
Neoplastic Process
Synonyms: Cancer metastatic to lung; Lung Metastases; Metastases to Lung; Metastasis to Lung; Metastasis to the Lung; Metastatic malignant neoplasm of lung; Metastatic malignant neoplasm to lung; Metastatic Malignant Neoplasm to the Lung; Metastatic Neoplasm to the Lung; Metastatic Tumor to the Lung; Pulmonary Metastasis; Pulmonary metastasis; Secondary cancer of lung; Secondary malignant neoplasm of lung; Secondary malignant tumor of lung
SNOMED CT: Secondary malignant tumor of lung (94391008); Pulmonary metastasis (94391008); Secondary cancer of lung (94391008); Secondary malignant neoplasm of lung (94391008); Metastatic malignant neoplasm to lung (94391008); Cancer metastatic to lung (94391008); Metastatic malignant neoplasm of lung (94391008)

Definition

The spread of a malignant neoplasm to the lung. This may be from a primary lung malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Professional guidelines

PubMed

Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

He XY, Gao Y, Ng D, Michalopoulou E, George S, Adrover JM, Sun L, Albrengues J, Daßler-Plenker J, Han X, Wan L, Wu XS, Shui LS, Huang YH, Liu B, Su C, Spector DL, Vakoc CR, Van Aelst L, Egeblad M
Cancer Cell 2024 Mar 11;42(3):474-486.e12. Epub 2024 Feb 22 doi: 10.1016/j.ccell.2024.01.013. PMID: 38402610Free PMC Article
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article
Bade BC, Possick JD
Clin Chest Med 2020 Jun;41(2):295-305. doi: 10.1016/j.ccm.2020.02.012. PMID: 32402364
Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, Ponce S, Ares LP, Leroy L, Audigier-Valette C, Felip E, Zerón-Medina J, Garrido P, Brosseau S, Zalcman G, Mazieres J, Caramela C, Lahmar J, Adam J, Chaput N, Soria JC, Besse B
JAMA Oncol 2018 Mar 1;4(3):351-357. doi: 10.1001/jamaoncol.2017.4771. PMID: 29327044Free PMC Article
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489

Diagnosis

Wittrock E, Hagner MD
N Engl J Med 2024 Sep 5;391(9):844. Epub 2024 Aug 31 doi: 10.1056/NEJMicm2403364. PMID: 39216098
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Samolski D, Duré R, Bentolila G, Castiglioni T
Monaldi Arch Chest Dis 2020 Sep 9;90(4) doi: 10.4081/monaldi.2020.1430. PMID: 32945642
Shah K, Yi ES, Erickson LA
Mayo Clin Proc 2018 Oct;93(10):1533-1534. doi: 10.1016/j.mayocp.2018.07.012. PMID: 30286838
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222

Therapy

Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Nam JG, Hwang EJ, Kim J, Park N, Lee EH, Kim HJ, Nam M, Lee JH, Park CM, Goo JM
Radiology 2023 Apr;307(2):e221894. Epub 2023 Feb 7 doi: 10.1148/radiol.221894. PMID: 36749213
Macbeth F, Fallowfield L
Br J Cancer 2020 Aug;123(4):499-500. Epub 2020 Jun 16 doi: 10.1038/s41416-020-0927-2. PMID: 32541870Free PMC Article
Kwapisz D
Breast Cancer 2019 Mar;26(2):138-146. Epub 2018 Oct 15 doi: 10.1007/s12282-018-0921-1. PMID: 30324552
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222

Prognosis

Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Petrelli F, Cortellini A, Indini A, Tomasello G, Ghidini M, Nigro O, Salati M, Dottorini L, Iaculli A, Varricchio A, Rampulla V, Barni S, Cabiddu M, Bossi A, Ghidini A, Zaniboni A
JAMA Netw Open 2021 Mar 1;4(3):e213520. doi: 10.1001/jamanetworkopen.2021.3520. PMID: 33779745Free PMC Article
Planchard D, Popat S, Kerr K, Novello S, Smit EF, Faivre-Finn C, Mok TS, Reck M, Van Schil PE, Hellmann MD, Peters S; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv192-iv237. doi: 10.1093/annonc/mdy275. PMID: 30285222
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article

Clinical prediction guides

McGinnis CS, Miao Z, Superville D, Yao W, Goga A, Reticker-Flynn NE, Winkler J, Satpathy AT
Cancer Cell 2024 Jun 10;42(6):1018-1031.e6. Epub 2024 May 30 doi: 10.1016/j.ccell.2024.05.004. PMID: 38821060Free PMC Article
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article
Winkelmann MT, Clasen S, Pereira PL, Hoffmann R
Br J Radiol 2019 Aug;92(1100):20180835. Epub 2019 Jun 6 doi: 10.1259/bjr.20180835. PMID: 31124700Free PMC Article
Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M
Sci Transl Med 2016 Oct 19;8(361):361ra138. doi: 10.1126/scitranslmed.aag1711. PMID: 27798263Free PMC Article
Gagnadoux F, Hureaux J, Vecellio L, Urban T, Le Pape A, Valo I, Montharu J, Leblond V, Boisdron-Celle M, Lerondel S, Majoral C, Diot P, Racineux JL, Lemarie E
J Aerosol Med Pulm Drug Deliv 2008 Mar;21(1):61-70. doi: 10.1089/jamp.2007.0656. PMID: 18518832

Recent systematic reviews

Gillespie CS, Mustafa MA, Richardson GE, Alam AM, Lee KS, Hughes DM, Escriu C, Zakaria R
J Thorac Oncol 2023 Dec;18(12):1703-1713. Epub 2023 Jun 29 doi: 10.1016/j.jtho.2023.06.017. PMID: 37392903
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050
Petrelli F, Cortellini A, Indini A, Tomasello G, Ghidini M, Nigro O, Salati M, Dottorini L, Iaculli A, Varricchio A, Rampulla V, Barni S, Cabiddu M, Bossi A, Ghidini A, Zaniboni A
JAMA Netw Open 2021 Mar 1;4(3):e213520. doi: 10.1001/jamanetworkopen.2021.3520. PMID: 33779745Free PMC Article
Conforti F, Pala L, Bagnardi V, De Pas T, Martinetti M, Viale G, Gelber RD, Goldhirsch A
Lancet Oncol 2018 Jun;19(6):737-746. Epub 2018 May 16 doi: 10.1016/S1470-2045(18)30261-4. PMID: 29778737

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