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Cutaneous Neurofibroma

MedGen UID:
577256
Concept ID:
C0346057
Neoplastic Process
Synonym: Neurofibromas, cutaneous
SNOMED CT: Neuroma cutis (254761009); Cutaneous neurofibroma (254761009)

Definition

A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Neurofibroma

Professional guidelines

PubMed

Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Peltonen S, Jannic A, Wolkenstein P
Eur J Med Genet 2022 Jan;65(1):104386. Epub 2021 Nov 9 doi: 10.1016/j.ejmg.2021.104386. PMID: 34768015
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003

Recent clinical studies

Etiology

Church C, Fay CX, Kriukov E, Liu H, Cannon A, Baldwin LA, Crossman DK, Korf B, Wallace MR, Gross AM, Widemann BC, Kesterson RA, Baranov P, Wallis D
Acta Neuropathol Commun 2024 Jun 21;12(1):102. doi: 10.1186/s40478-024-01821-z. PMID: 38907342Free PMC Article
Richey P, Funk M, Sakamoto F, Plotkin S, Ly I, Jordan J, Muzikansky A, Roberts J, Farinelli W, Levin Y, Garibyan L, Blakeley JO, Anderson RR
J Am Acad Dermatol 2024 Apr;90(4):767-774. Epub 2023 Dec 10 doi: 10.1016/j.jaad.2023.11.058. PMID: 38086517
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Verma SK, Riccardi VM, Plotkin SR, Weinberg H, Anderson RR, Blakeley JO, Jarnagin K, Lee J
Neurology 2018 Jul 10;91(2 Suppl 1):S21-S30. doi: 10.1212/WNL.0000000000005791. PMID: 29987132
Raffin D, Zaragoza J, Georgescou G, Mourtada Y, Maruani A, Ossant F, Patat F, Vaillant L, Machet L
Eur J Dermatol 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015. PMID: 28524060

Diagnosis

Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Meyer A
Curr Opin Neurol 2020 Oct;33(5):575-586. doi: 10.1097/WCO.0000000000000857. PMID: 32833749
Lee YH, Kwon MJ, Park JH, Jeong SJ, Kim TH, Jeong HW, Lee SH
Intern Med 2020 Jul 1;59(13):1665-1669. Epub 2020 Apr 9 doi: 10.2169/internalmedicine.4148-19. PMID: 32269189Free PMC Article
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003
Gómez-Mateo Mdel C, Compañ-Quilis A, Monteagudo C
J Cutan Pathol 2015 Nov;42(11):884-8. Epub 2015 Sep 9 doi: 10.1111/cup.12572. PMID: 26269328

Therapy

Richey P, Funk M, Sakamoto F, Plotkin S, Ly I, Jordan J, Muzikansky A, Roberts J, Farinelli W, Levin Y, Garibyan L, Blakeley JO, Anderson RR
J Am Acad Dermatol 2024 Apr;90(4):767-774. Epub 2023 Dec 10 doi: 10.1016/j.jaad.2023.11.058. PMID: 38086517
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Peltonen S, Jannic A, Wolkenstein P
Eur J Med Genet 2022 Jan;65(1):104386. Epub 2021 Nov 9 doi: 10.1016/j.ejmg.2021.104386. PMID: 34768015
Blakeley JO, Wolkenstein P, Widemann BC, Lee J, Le LQ, Jackson R, Stathis M, Verma SK
Neurology 2018 Jul 10;91(2 Suppl 1):S1-S4. doi: 10.1212/WNL.0000000000005789. PMID: 29987129Free PMC Article
Raffin D, Zaragoza J, Georgescou G, Mourtada Y, Maruani A, Ossant F, Patat F, Vaillant L, Machet L
Eur J Dermatol 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015. PMID: 28524060

Prognosis

Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
Friedrich RE, Nörnberg LKN, Hagel C
Anticancer Res 2022 Mar;42(3):1247-1261. doi: 10.21873/anticanres.15592. PMID: 35220215
Wallis D, Stemmer-Rachamimov A, Adsit S, Korf B, Pichard D, Blakeley J, Sarin KY; REiNS International Collaboration
Neurology 2021 Aug 17;97(7 Suppl 1):S42-S49. Epub 2021 Jul 6 doi: 10.1212/WNL.0000000000012426. PMID: 34230199Free PMC Article
Ehara Y, Yamamoto O, Kosaki K, Yoshida Y
J Dermatol 2018 Jan;45(1):53-57. Epub 2017 Sep 11 doi: 10.1111/1346-8138.14025. PMID: 28891076
Kreusel KM
Fam Cancer 2005;4(1):43-7. doi: 10.1007/s10689-004-1327-0. PMID: 15883709

Clinical prediction guides

Church C, Fay CX, Kriukov E, Liu H, Cannon A, Baldwin LA, Crossman DK, Korf B, Wallace MR, Gross AM, Widemann BC, Kesterson RA, Baranov P, Wallis D
Acta Neuropathol Commun 2024 Jun 21;12(1):102. doi: 10.1186/s40478-024-01821-z. PMID: 38907342Free PMC Article
García-Martínez FJ, Alfageme F, Duat-Rodríguez A, Andrés Esteban EM, Hernández-Martín A
Ultraschall Med 2023 Apr;44(2):e118-e125. Epub 2021 Nov 24 doi: 10.1055/a-1640-9621. PMID: 34820795
Maguiness S, Berman Y, Rubin N, Dodds M, Plotkin SR, Wong C, Moertel C; REiNS International Collaboration
Neurology 2021 Aug 17;97(7 Suppl 1):S25-S31. Epub 2021 Jul 6 doi: 10.1212/WNL.0000000000012427. PMID: 34230204Free PMC Article
Wallis D, Stemmer-Rachamimov A, Adsit S, Korf B, Pichard D, Blakeley J, Sarin KY; REiNS International Collaboration
Neurology 2021 Aug 17;97(7 Suppl 1):S42-S49. Epub 2021 Jul 6 doi: 10.1212/WNL.0000000000012426. PMID: 34230199Free PMC Article
Raffin D, Zaragoza J, Georgescou G, Mourtada Y, Maruani A, Ossant F, Patat F, Vaillant L, Machet L
Eur J Dermatol 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015. PMID: 28524060

Recent systematic reviews

Rozza-de-Menezes RE, Brum CAI, Gaglionone NC, de Sousa Almeida LM, Andrade-Losso RM, Paiva BVB, Faveret PLS, da Silva AV, Siqueira OHK, Riccardi VM, Cunha KS
J Cutan Pathol 2018 Oct;45(10):743-753. Epub 2018 Aug 1 doi: 10.1111/cup.13315. PMID: 29959804

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