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Nephrotic Syndrome with Lesion of Membranous Glomerulonephritis

MedGen UID:
57621
•Concept ID:
C0156228
•
Disease or Syndrome

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the glomerular capillaries due to the deposition of immune complexes and subsequent thickening of the glomerular basement membrane. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome with Lesion of Membranous Glomerulonephritis

Professional guidelines

PubMed

IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics.
Gilani SI, Buglioni A, Cornell LD
Semin Diagn Pathol 2024 Mar;41(2):88-94. Epub 2023 Dec 20 doi: 10.1053/j.semdp.2023.12.001. PMID: 38246802
Role of light and immunofluorescence microscopy to differentiate primary and secondary membranous nephropathy.
Basu K, Sengupta M, Mukherjee S, Karmakar S, Roychowdhury A, Bandopadhyay M
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):821-827. doi: 10.4103/ijpm.ijpm_22_21. PMID: 36308187
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article

Recent clinical studies

Etiology

Clinicopathologic features and long-term prognosis of hepatitis B virus-associated glomerulonephritis: a retrospective cohort study.
Lu H, Li Y, Lai M, Guan T, Yu Y, Zheng Z, Zhuang Y
J Nephrol 2023 Nov;36(8):2335-2344. Epub 2023 Jul 31 doi: 10.1007/s40620-023-01685-x. PMID: 37523106Free PMC Article
Clinical characteristics and outcomes of idiopathic membranous nephropathy with glomerular IgM deposits.
Yu-Zhu X, Na-Ya H, Ya-Gui Q, Xiong-Hui C, Zhi-Jian L, Wei C, Xin W
Clin Exp Med 2022 Aug;22(3):455-464. Epub 2021 Oct 26 doi: 10.1007/s10238-021-00768-y. PMID: 34698950
Clinical and pathological features of idiopathic membranous nephropathy with focal segmental sclerosis.
Li J, Chen B, Gao C, Huang J, Wang Y, Zhang S, Xu Y, Guo W, Wang R
BMC Nephrol 2019 Dec 16;20(1):467. doi: 10.1186/s12882-019-1641-2. PMID: 31842785Free PMC Article
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article

Diagnosis

IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics.
Gilani SI, Buglioni A, Cornell LD
Semin Diagn Pathol 2024 Mar;41(2):88-94. Epub 2023 Dec 20 doi: 10.1053/j.semdp.2023.12.001. PMID: 38246802
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Glomerulonephritis Histopathological Pattern Change.
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
Hepatitis C and renal disease: epidemiology, diagnosis, pathogenesis and therapy.
Morales JM, Kamar N, Rostaing L
Contrib Nephrol 2012;176:10-23. Epub 2012 Jan 30 doi: 10.1159/000333772. PMID: 22310777

Therapy

Clinicopathologic features and long-term prognosis of hepatitis B virus-associated glomerulonephritis: a retrospective cohort study.
Lu H, Li Y, Lai M, Guan T, Yu Y, Zheng Z, Zhuang Y
J Nephrol 2023 Nov;36(8):2335-2344. Epub 2023 Jul 31 doi: 10.1007/s40620-023-01685-x. PMID: 37523106Free PMC Article
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article
Hepatitis C and renal disease: epidemiology, diagnosis, pathogenesis and therapy.
Morales JM, Kamar N, Rostaing L
Contrib Nephrol 2012;176:10-23. Epub 2012 Jan 30 doi: 10.1159/000333772. PMID: 22310777

Prognosis

Clinicopathologic features and long-term prognosis of hepatitis B virus-associated glomerulonephritis: a retrospective cohort study.
Lu H, Li Y, Lai M, Guan T, Yu Y, Zheng Z, Zhuang Y
J Nephrol 2023 Nov;36(8):2335-2344. Epub 2023 Jul 31 doi: 10.1007/s40620-023-01685-x. PMID: 37523106Free PMC Article
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Glomerulonephritis Histopathological Pattern Change.
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article

Clinical prediction guides

Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Glomerulonephritis Histopathological Pattern Change.
AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387Free PMC Article
Clinical and pathological features of idiopathic membranous nephropathy with focal segmental sclerosis.
Li J, Chen B, Gao C, Huang J, Wang Y, Zhang S, Xu Y, Guo W, Wang R
BMC Nephrol 2019 Dec 16;20(1):467. doi: 10.1186/s12882-019-1641-2. PMID: 31842785Free PMC Article
Nephrotic syndrome associated with Kimura's disease: a case report and literature review.
Ren S, Li XY, Wang F, Zhang P, Zhang Y, Li GS, Wang L, Zhong X
BMC Nephrol 2018 Nov 8;19(1):316. doi: 10.1186/s12882-018-1123-y. PMID: 30409112Free PMC Article
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article

Recent systematic reviews

Mercury-associated nephrotic syndrome: a case report and systematic review of the literature.
Miller S, Pallan S, Gangji AS, Lukic D, Clase CM
Am J Kidney Dis 2013 Jul;62(1):135-8. Epub 2013 Apr 18 doi: 10.1053/j.ajkd.2013.02.372. PMID: 23602193

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