U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Drug-induced anaphylaxis

MedGen UID:
576123
•Concept ID:
C0344168
•
Disease or Syndrome
Synonym: Drug induced anaphylaxis
SNOMED CT: Drug-induced anaphylaxis (241937000)
 
HPO: HP:0410149

Definition

A form of anaphylaxis that is triggered by intake of drugs or medications. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced anaphylaxis

Professional guidelines

PubMed

Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: General Concepts.
Broyles AD, Banerji A, Castells M
J Allergy Clin Immunol Pract 2020 Oct;8(9S):S3-S15. Epub 2020 Aug 11 doi: 10.1016/j.jaip.2020.08.002. PMID: 32791249
Recognition and Management of Anaphylaxis in Older Adults.
Plagova A, Nykamp D
Consult Pharm 2017 Jul 1;32(7):398-405. doi: 10.4140/TCP.n.2017.398. PMID: 28701251
Anaphylaxis: diagnosis and management.
Brown SG, Mullins RJ, Gold MS
Med J Aust 2006 Sep 4;185(5):283-9. doi: 10.5694/j.1326-5377.2006.tb00619.x. PMID: 16948628

Recent clinical studies

Etiology

Hypersensitivity reactions to chemotherapy: an EAACI Position Paper.
Pagani M, Bavbek S, Alvarez-Cuesta E, Berna Dursun A, Bonadonna P, Castells M, Cernadas J, Chiriac A, Sahar H, Madrigal-Burgaleta R, Sanchez Sanchez S
Allergy 2022 Feb;77(2):388-403. Epub 2021 Oct 26 doi: 10.1111/all.15113. PMID: 34587281
Drug-Induced Anaphylaxis: An Update on Epidemiology and Risk Factors.
Regateiro FS, Marques ML, Gomes ER
Int Arch Allergy Immunol 2020;181(7):481-487. Epub 2020 May 12 doi: 10.1159/000507445. PMID: 32396909
Cross-reactivity in β-Lactam Allergy.
Zagursky RJ, Pichichero ME
J Allergy Clin Immunol Pract 2018 Jan-Feb;6(1):72-81.e1. Epub 2017 Oct 7 doi: 10.1016/j.jaip.2017.08.027. PMID: 29017833
Mastocytosis and Anaphylaxis.
Schuch A, Brockow K
Immunol Allergy Clin North Am 2017 Feb;37(1):153-164. Epub 2016 Oct 28 doi: 10.1016/j.iac.2016.08.017. PMID: 27886904
Anaphylaxis to drugs.
Kuruvilla M, Khan DA
Immunol Allergy Clin North Am 2015 May;35(2):303-19. Epub 2015 Mar 3 doi: 10.1016/j.iac.2015.01.008. PMID: 25841553

Diagnosis

Drug-induced Anaphylaxis.
Labella M, de Santa María RS, Bogas G, Salas M, Fernández TD, Mayorga C, Torres MJ, Doña I
Curr Pharm Des 2023;29(3):196-208. doi: 10.2174/1381612829666221024154951. PMID: 36284381
Hypersensitivity reactions to chemotherapy: an EAACI Position Paper.
Pagani M, Bavbek S, Alvarez-Cuesta E, Berna Dursun A, Bonadonna P, Castells M, Cernadas J, Chiriac A, Sahar H, Madrigal-Burgaleta R, Sanchez Sanchez S
Allergy 2022 Feb;77(2):388-403. Epub 2021 Oct 26 doi: 10.1111/all.15113. PMID: 34587281
Drug-induced anaphylaxis in children.
Cardinale F, Amato D, Mastrototaro MF, Caffarelli C, Crisafulli G, Franceschini F, Liotti L, Caimmi S, Bottau P, Saretta F, Mori F, Bernardini R
Acta Biomed 2019 Jan 30;90(3-S):30-35. doi: 10.23750/abm.v90i3-S.8172. PMID: 30830059Free PMC Article
Drug-Induced Anaphylaxis.
Aun MV, Kalil J, Giavina-Bianchi P
Immunol Allergy Clin North Am 2017 Nov;37(4):629-641. Epub 2017 Aug 9 doi: 10.1016/j.iac.2017.06.002. PMID: 28965631
Anaphylaxis to drugs.
Kuruvilla M, Khan DA
Immunol Allergy Clin North Am 2015 May;35(2):303-19. Epub 2015 Mar 3 doi: 10.1016/j.iac.2015.01.008. PMID: 25841553

Therapy

Drug Allergy in Women.
Lee EY, Copaescu AM, Trubiano JA, Phillips EJ, Wolfson AR, Ramsey A
J Allergy Clin Immunol Pract 2023 Dec;11(12):3615-3623. Epub 2023 Oct 5 doi: 10.1016/j.jaip.2023.09.031. PMID: 37805007
Hypersensitivity reactions to chemotherapy: an EAACI Position Paper.
Pagani M, Bavbek S, Alvarez-Cuesta E, Berna Dursun A, Bonadonna P, Castells M, Cernadas J, Chiriac A, Sahar H, Madrigal-Burgaleta R, Sanchez Sanchez S
Allergy 2022 Feb;77(2):388-403. Epub 2021 Oct 26 doi: 10.1111/all.15113. PMID: 34587281
Drug-induced anaphylaxis: is it an epidemic?
Giavina-Bianchi P, Aun MV, Kalil J
Curr Opin Allergy Clin Immunol 2018 Feb;18(1):59-65. doi: 10.1097/ACI.0000000000000411. PMID: 29135486
Cross-reactivity in β-Lactam Allergy.
Zagursky RJ, Pichichero ME
J Allergy Clin Immunol Pract 2018 Jan-Feb;6(1):72-81.e1. Epub 2017 Oct 7 doi: 10.1016/j.jaip.2017.08.027. PMID: 29017833
Drug-Induced Anaphylaxis.
Aun MV, Kalil J, Giavina-Bianchi P
Immunol Allergy Clin North Am 2017 Nov;37(4):629-641. Epub 2017 Aug 9 doi: 10.1016/j.iac.2017.06.002. PMID: 28965631

Prognosis

Drug-Induced Anaphylaxis: An Update on Epidemiology and Risk Factors.
Regateiro FS, Marques ML, Gomes ER
Int Arch Allergy Immunol 2020;181(7):481-487. Epub 2020 May 12 doi: 10.1159/000507445. PMID: 32396909
Drug-induced anaphylaxis: is it an epidemic?
Giavina-Bianchi P, Aun MV, Kalil J
Curr Opin Allergy Clin Immunol 2018 Feb;18(1):59-65. doi: 10.1097/ACI.0000000000000411. PMID: 29135486
Cross-reactivity in β-Lactam Allergy.
Zagursky RJ, Pichichero ME
J Allergy Clin Immunol Pract 2018 Jan-Feb;6(1):72-81.e1. Epub 2017 Oct 7 doi: 10.1016/j.jaip.2017.08.027. PMID: 29017833
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Preventing and managing drug-induced anaphylaxis.
Drain KL, Volcheck GW
Drug Saf 2001;24(11):843-53. doi: 10.2165/00002018-200124110-00005. PMID: 11665871

Clinical prediction guides

Cross-reactivity in β-Lactam Allergy.
Zagursky RJ, Pichichero ME
J Allergy Clin Immunol Pract 2018 Jan-Feb;6(1):72-81.e1. Epub 2017 Oct 7 doi: 10.1016/j.jaip.2017.08.027. PMID: 29017833
Clindamycin-induced hypersensitivity reaction.
Bulloch MN, Baccas JT, Arnold S
Infection 2016 Jun;44(3):357-9. Epub 2015 Jul 28 doi: 10.1007/s15010-015-0826-2. PMID: 26216470
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Anaphylaxis: diagnosis and management.
Brown SG, Mullins RJ, Gold MS
Med J Aust 2006 Sep 4;185(5):283-9. doi: 10.5694/j.1326-5377.2006.tb00619.x. PMID: 16948628
Preventing and managing drug-induced anaphylaxis.
Drain KL, Volcheck GW
Drug Saf 2001;24(11):843-53. doi: 10.2165/00002018-200124110-00005. PMID: 11665871

Recent systematic reviews

Health-Related Quality of Life and Mental Health in Drug Hypersensitivity Reactions and Drug-Induced Anaphylaxis: A Systematic Review and Meta-Analysis.
Martini M, Di Taranto M, Höfer V, Worm M, Bilò MB
J Allergy Clin Immunol Pract 2023 Jun;11(6):1876-1890. Epub 2023 Mar 21 doi: 10.1016/j.jaip.2023.03.012. PMID: 36958518
Economic burden of drug-induced anaphylaxis: what can we do better?
Cardoso B, Moscoso T, Morais-Almeida M, Demoly P, Tanno LK
Curr Opin Allergy Clin Immunol 2022 Aug 1;22(4):234-241. doi: 10.1097/ACI.0000000000000836. PMID: 35852897
Global patterns of drug allergy-induced fatalities: a wake-up call to prevent avoidable deaths.
Tanno LK, Gauthier A, Allichon S, Demoly P
Curr Opin Allergy Clin Immunol 2022 Aug 1;22(4):215-220. doi: 10.1097/ACI.0000000000000835. PMID: 35852895
Drug-induced anaphylaxis: seven-year single-center survey.
Mota I, Gaspar Â, Benito-Garcia F, Correia M, Chambel M, Morais-Almeida M
Eur Ann Allergy Clin Immunol 2018 Sep;50(5):211-216. Epub 2018 Jul 20 doi: 10.23822/EurAnnACI.1764-1489.66. PMID: 30028111

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...