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Micronodular adrenal hyperplasia

MedGen UID:
575066
•Concept ID:
C0342496
•
Disease or Syndrome
Synonym: Micronodular Adrenal Hyperplasia
SNOMED CT: Micronodular adrenal hyperplasia (237779006)

Definition

Adrenal hyperfunction associated with multiple bilateral adrenal nodules, usually less than one centimeter in diameter. [from NCI]

Professional guidelines

PubMed

Continuous dexamethasone infusion for seven hours in patients with the Cushing syndrome. A superior differential diagnostic test.
Biemond P, de Jong FH, Lamberts SW
Ann Intern Med 1990 May 15;112(10):738-42. doi: 10.7326/0003-4819-112-10-738. PMID: 2158760

Recent clinical studies

Etiology

CT-based radiomics nomogram for differentiation of adrenal hyperplasia from lipid-poor adenoma: an exploratory study.
Yuan H, Kang B, Sun K, Qin S, Ji C, Wang X
BMC Med Imaging 2023 Jan 7;23(1):4. doi: 10.1186/s12880-022-00951-x. PMID: 36611159Free PMC Article
Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Operative management of Cushing syndrome secondary to micronodular adrenal hyperplasia.
Powell AC, Stratakis CA, Patronas NJ, Steinberg SM, Batista D, Alexander HR, Pingpank JF, Keil M, Bartlett DL, Libutti SK
Surgery 2008 Jun;143(6):750-8. doi: 10.1016/j.surg.2008.03.022. PMID: 18549891Free PMC Article
Hyperadrenalism in childhood and adolescence.
Thomas CG Jr, Smith AT, Griffith JM, Askin FB
Ann Surg 1984 May;199(5):538-48. doi: 10.1097/00000658-198405000-00008. PMID: 6721603Free PMC Article

Diagnosis

Current approach of primary bilateral adrenal hyperplasia.
Delivanis DA, Vassiliadi DA, Tsagarakis S
Curr Opin Endocrinol Diabetes Obes 2022 Jun 1;29(3):243-252. doi: 10.1097/MED.0000000000000725. PMID: 35621176
Adrenocortical hyperplasia: A multifaceted disease.
Bourdeau I, Parisien-La Salle S, Lacroix A
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101386. Epub 2020 Feb 4 doi: 10.1016/j.beem.2020.101386. PMID: 32115357
Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Genetics of micronodular adrenal hyperplasia and Carney complex.
Tirosh A, Valdés N, Stratakis CA
Presse Med 2018 Jul-Aug;47(7-8 Pt 2):e127-e137. Epub 2018 Aug 6 doi: 10.1016/j.lpm.2018.07.005. PMID: 30093212
Unraveling the molecular basis of micronodular adrenal hyperplasia.
Horvath A, Stratakis CA
Curr Opin Endocrinol Diabetes Obes 2008 Jun;15(3):227-33. doi: 10.1097/MED.0b013e3282fe7416. PMID: 18438169Free PMC Article

Therapy

Continuous dexamethasone infusion for seven hours in patients with the Cushing syndrome. A superior differential diagnostic test.
Biemond P, de Jong FH, Lamberts SW
Ann Intern Med 1990 May 15;112(10):738-42. doi: 10.7326/0003-4819-112-10-738. PMID: 2158760

Prognosis

Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome.
Di Dalmazi G, Timmers HJLM, Arnaldi G, Küsters B, Scarpelli M, Bathon K, Calebiro D, Beuschlein F, Hermus A, Reincke M
J Clin Endocrinol Metab 2019 Nov 1;104(11):5651-5657. doi: 10.1210/jc.2018-02209. PMID: 31276155
Continuous dexamethasone infusion for seven hours in patients with the Cushing syndrome. A superior differential diagnostic test.
Biemond P, de Jong FH, Lamberts SW
Ann Intern Med 1990 May 15;112(10):738-42. doi: 10.7326/0003-4819-112-10-738. PMID: 2158760

Clinical prediction guides

Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome.
Di Dalmazi G, Timmers HJLM, Arnaldi G, Küsters B, Scarpelli M, Bathon K, Calebiro D, Beuschlein F, Hermus A, Reincke M
J Clin Endocrinol Metab 2019 Nov 1;104(11):5651-5657. doi: 10.1210/jc.2018-02209. PMID: 31276155
Operative management of Cushing syndrome secondary to micronodular adrenal hyperplasia.
Powell AC, Stratakis CA, Patronas NJ, Steinberg SM, Batista D, Alexander HR, Pingpank JF, Keil M, Bartlett DL, Libutti SK
Surgery 2008 Jun;143(6):750-8. doi: 10.1016/j.surg.2008.03.022. PMID: 18549891Free PMC Article
Hypercortisolism with non-pigmented micronodular adrenal hyperplasia: transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.
Hocher B, Bähr V, Dorfmüller S, Oelkers W
Acta Endocrinol (Copenh) 1993 Feb;128(2):120-5. doi: 10.1530/acta.0.1280120. PMID: 8383903
Continuous dexamethasone infusion for seven hours in patients with the Cushing syndrome. A superior differential diagnostic test.
Biemond P, de Jong FH, Lamberts SW
Ann Intern Med 1990 May 15;112(10):738-42. doi: 10.7326/0003-4819-112-10-738. PMID: 2158760

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