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Diffuse goiter

MedGen UID:
574834
•Concept ID:
C0342114
•
Disease or Syndrome
Synonym: Diffuse Goiter
SNOMED CT: Diffuse goiter (237494009)

Definition

Enlargement of the entire thyroid gland without discrete mass(es). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse goiter

Professional guidelines

PubMed

Approach to and treatment of goiters.
Medeiros-Neto G, Camargo RY, Tomimori EK
Med Clin North Am 2012 Mar;96(2):351-68. doi: 10.1016/j.mcna.2012.01.010. PMID: 22443980
Treatment of toxic diffuse goiter.
Stanbury JB
Postgrad Med 1969 Jul;46(1):137-9. doi: 10.1080/00325481.1969.11697210. PMID: 4183010
Chronic treatment of toxic diffuse goiter.
REVENO WS, ROSENBAUM H
AMA Arch Intern Med 1957 Oct;100(4):642-6. doi: 10.1001/archinte.1957.00260100126015. PMID: 13457490

Recent clinical studies

Etiology

Proteomic profiling of thyroid tissue in patients with obesity and benign diffuse goiter.
Benabdelkamel H, Rafiullah M, Masood A, Alsaif A, Musambil M, Alfadda AA
Front Endocrinol (Lausanne) 2022;13:923465. Epub 2022 Jul 28 doi: 10.3389/fendo.2022.923465. PMID: 35966064Free PMC Article
Approach to and treatment of goiters.
Medeiros-Neto G, Camargo RY, Tomimori EK
Med Clin North Am 2012 Mar;96(2):351-68. doi: 10.1016/j.mcna.2012.01.010. PMID: 22443980
Hyperthyroidism.
Sendrowski DP
Optom Clin 1994;3(4):87-97. PMID: 7919695
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study.
Steinbach JJ, Donoghue GD, Goldman JK
J Nucl Med 1979 Dec;20(12):1263-7. PMID: 94089
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents.
Barnes HV, Blizzard RM
J Pediatr 1977 Aug;91(2):313-20. doi: 10.1016/s0022-3476(77)80843-3. PMID: 69022

Diagnosis

Isolated adrenocorticotropin deficiency associated with painless thyroiditis: a case report and review of the literature.
Mizokami T, Itoh Y, Sato Y, Nunoi K, Okamura K
Kurume Med J 2012;59(3-4):71-7. doi: 10.2739/kurumemedj.59.71. PMID: 23823017
Thyroid-related ophthalmology.
Zobian J, Maus M
Curr Opin Ophthalmol 1998 Dec;9(6):105-10. doi: 10.1097/00055735-199812000-00019. PMID: 10387329
Hyperthyroidism.
Sendrowski DP
Optom Clin 1994;3(4):87-97. PMID: 7919695
Differential diagnosis of goiter.
Mahoney CP
Pediatr Clin North Am 1987 Aug;34(4):891-905. doi: 10.1016/s0031-3955(16)36293-9. PMID: 3302898
Thyrolymphography.
Smyrnis SA, Kolios AS, Katsas AG, Spanos HS, Vlachos JD
Am J Surg 1975 Jun;129(6):646-50. doi: 10.1016/0002-9610(75)90338-4. PMID: 165738

Therapy

Isolated adrenocorticotropin deficiency associated with painless thyroiditis: a case report and review of the literature.
Mizokami T, Itoh Y, Sato Y, Nunoi K, Okamura K
Kurume Med J 2012;59(3-4):71-7. doi: 10.2739/kurumemedj.59.71. PMID: 23823017
Thyroid-related ophthalmology.
Zobian J, Maus M
Curr Opin Ophthalmol 1998 Dec;9(6):105-10. doi: 10.1097/00055735-199812000-00019. PMID: 10387329
Differences and similarities in the treatment of diffuse goiter in Europe and the United States.
Wartofsky L, Glinoer D, Solomon B, Lagasse R
Exp Clin Endocrinol 1991 May;97(2-3):243-51. doi: 10.1055/s-0029-1211072. PMID: 1717298
Differential diagnosis of goiter.
Mahoney CP
Pediatr Clin North Am 1987 Aug;34(4):891-905. doi: 10.1016/s0031-3955(16)36293-9. PMID: 3302898
Treatment of toxic diffuse goiter.
Stanbury JB
Postgrad Med 1969 Jul;46(1):137-9. doi: 10.1080/00325481.1969.11697210. PMID: 4183010

Prognosis

The Relationship between Insulin Resistance and Thyroid Volume in Georgia.
Lomtadze N, Giorgadze E, Janjgava S, Kacharava T, Taboridze I
Endocr Metab Immune Disord Drug Targets 2023;23(10):1318-1325. doi: 10.2174/1871530323666230220093432. PMID: 36825717
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Thyrotoxic hypokalemic periodic paralysis in a Hispanic male.
Zumo LA, Terzian C, Brannan T
J Natl Med Assoc 2002 May;94(5):383-6. PMID: 12069220Free PMC Article
Diagnostic dilemma. The goiter.
Alter CA, Moshang T Jr
Pediatr Clin North Am 1991 Jun;38(3):567-78. doi: 10.1016/s0031-3955(16)38118-4. PMID: 2047139
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents.
Barnes HV, Blizzard RM
J Pediatr 1977 Aug;91(2):313-20. doi: 10.1016/s0022-3476(77)80843-3. PMID: 69022

Clinical prediction guides

The Relationship between Insulin Resistance and Thyroid Volume in Georgia.
Lomtadze N, Giorgadze E, Janjgava S, Kacharava T, Taboridze I
Endocr Metab Immune Disord Drug Targets 2023;23(10):1318-1325. doi: 10.2174/1871530323666230220093432. PMID: 36825717
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis.
Kamel N, Uysal AR, Koloğlu S, Erdoğan G, Senel M, Polat H
Endocrinologie 1988 Apr-Jun;26(2):99-105. PMID: 3413443
T4-thyrotoxicosis.
Dorfman SG, Young RL
Arch Intern Med 1978 Jun;138(6):1016-7. PMID: 580554

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