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Non-necrotizing granuloma

MedGen UID:
569107
•Concept ID:
C0333418
•
Pathologic Function
Synonyms: Non-caseating granuloma; Non-caseating granulomatous inflammation; Non-Necrotizing Granuloma; Non-necrotizing granulomatous inflammation
SNOMED CT: Non-necrotizing granulomatous inflammation (71282004); Non-necrotizing granuloma (71282004); Non-caseating granuloma (71282004); Non-caseating granulomatous inflammation (71282004)
 
HPO: HP:0033805

Definition

A granuloma which is not associated with necrotic changes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-necrotizing granuloma

Professional guidelines

PubMed

Clinical Features, Histopathology and Differential Diagnosis of Sarcoidosis.
Tana C, Donatiello I, Caputo A, Tana M, Naccarelli T, Mantini C, Ricci F, Ticinesi A, Meschi T, Cipollone F, Giamberardino MA
Cells 2021 Dec 26;11(1) doi: 10.3390/cells11010059. PMID: 35011621Free PMC Article
Hypersensitivity pneumonia: the role of lung biopsy in diagnosis and management.
Myers JL
Mod Pathol 2012 Jan;25 Suppl 1:S58-67. doi: 10.1038/modpathol.2011.152. PMID: 22214971
Sarcoidosis of the skin--a dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition.
Tchernev G, Patterson JW, Nenoff P, Horn LC
J Eur Acad Dermatol Venereol 2010 Feb;24(2):125-37. Epub 2009 Aug 17 doi: 10.1111/j.1468-3083.2009.03396.x. PMID: 19689445

Recent clinical studies

Etiology

Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
Elahi M, Talreja J, Steinbauer B, Koth LL, Samavati L
Sci Rep 2022 Oct 7;12(1):16906. doi: 10.1038/s41598-022-21212-5. PMID: 36207373Free PMC Article
Granulomatous diseases of the central nervous system: Approach to diagnosis.
Challa S
Indian J Pathol Microbiol 2022 May;65(Supplement):S125-S134. doi: 10.4103/ijpm.ijpm_1067_21. PMID: 35562143
Histopathologic Analysis of Surgically Resected Lungs of Patients with Non-tuberculous Mycobacterial Lung Disease: a Retrospective and Hypothesis-generating Study.
Choi S, Potts KJ, Althoff MD, Jimenez G, Bai X, Calhoun KM, Cool CD, Chan ED
Yale J Biol Med 2021 Dec;94(4):527-535. Epub 2021 Dec 29 PMID: 34970090Free PMC Article
Enterobiasis mimicking Crohn's disease.
Fernandez-Flores A, Dajil S
Indian J Gastroenterol 2004 Jul-Aug;23(4):149-50. PMID: 15333976
Transforming growth factor-beta1 in sarcoidosis.
Salez F, Gosset P, Copin MC, Lamblin Degros C, Tonnel AB, Wallaert B
Eur Respir J 1998 Oct;12(4):913-9. doi: 10.1183/09031936.98.12040913. PMID: 9817168

Diagnosis

Human T-cell Lymphotropic Virus Type-1-associated Bronchioloalveolar Disorder with Non-necrotizing Granulomas: A Case Report and Literature Review.
Kimura S, Umeda Y, Egashira R, Tabata K, Muramoto A, Morita M, Yamaguchi M, Waseda Y, Imamura Y, Yamauchi T, Ishizuka T
Intern Med 2024 Apr 15;63(8):1149-1155. Epub 2023 Sep 1 doi: 10.2169/internalmedicine.2201-23. PMID: 37661452Free PMC Article
Granulomatous diseases of the central nervous system: Approach to diagnosis.
Challa S
Indian J Pathol Microbiol 2022 May;65(Supplement):S125-S134. doi: 10.4103/ijpm.ijpm_1067_21. PMID: 35562143
Enterobius vermicularis Infestation Mimicking Rectal Malignancy.
Akıncı O, Kepil N, Erzin YZ, Zengin AK
Turkiye Parazitol Derg 2020 Mar 20;44(1):58-60. doi: 10.4274/tpd.galenos.2019.6617. PMID: 32212596
Sarcoidosis and common variable immunodeficiency: similarities and differences.
Verbsky JW, Routes JM
Semin Respir Crit Care Med 2014 Jun;35(3):330-5. Epub 2014 Jul 9 doi: 10.1055/s-0034-1376862. PMID: 25007085
Enterobiasis mimicking Crohn's disease.
Fernandez-Flores A, Dajil S
Indian J Gastroenterol 2004 Jul-Aug;23(4):149-50. PMID: 15333976

Therapy

Histopathologic Spectrum of Intraoral Irritant and Contact Hypersensitivity Reactions: A Series of 12 cases.
Wang D, Woo SB
Head Neck Pathol 2021 Dec;15(4):1172-1184. Epub 2021 Apr 26 doi: 10.1007/s12105-021-01330-8. PMID: 33904012Free PMC Article
A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.
Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C
J Med Case Rep 2018 Apr 13;12(1):94. doi: 10.1186/s13256-018-1632-0. PMID: 29650028Free PMC Article
Enterobiasis mimicking Crohn's disease.
Fernandez-Flores A, Dajil S
Indian J Gastroenterol 2004 Jul-Aug;23(4):149-50. PMID: 15333976
Transforming growth factor-beta1 in sarcoidosis.
Salez F, Gosset P, Copin MC, Lamblin Degros C, Tonnel AB, Wallaert B
Eur Respir J 1998 Oct;12(4):913-9. doi: 10.1183/09031936.98.12040913. PMID: 9817168

Prognosis

Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
Elahi M, Talreja J, Steinbauer B, Koth LL, Samavati L
Sci Rep 2022 Oct 7;12(1):16906. doi: 10.1038/s41598-022-21212-5. PMID: 36207373Free PMC Article
A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.
Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C
J Med Case Rep 2018 Apr 13;12(1):94. doi: 10.1186/s13256-018-1632-0. PMID: 29650028Free PMC Article
Epidemiology of cutaneous sarcoidosis, 1976-2013: a population-based study from Olmsted County, Minnesota.
Ungprasert P, Wetter DA, Crowson CS, Matteson EL
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1799-1804. Epub 2016 Jun 21 doi: 10.1111/jdv.13760. PMID: 27324138Free PMC Article
Enterobiasis mimicking Crohn's disease.
Fernandez-Flores A, Dajil S
Indian J Gastroenterol 2004 Jul-Aug;23(4):149-50. PMID: 15333976
Transforming growth factor-beta1 in sarcoidosis.
Salez F, Gosset P, Copin MC, Lamblin Degros C, Tonnel AB, Wallaert B
Eur Respir J 1998 Oct;12(4):913-9. doi: 10.1183/09031936.98.12040913. PMID: 9817168

Clinical prediction guides

Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
Elahi M, Talreja J, Steinbauer B, Koth LL, Samavati L
Sci Rep 2022 Oct 7;12(1):16906. doi: 10.1038/s41598-022-21212-5. PMID: 36207373Free PMC Article
Epidemiology of cutaneous sarcoidosis, 1976-2013: a population-based study from Olmsted County, Minnesota.
Ungprasert P, Wetter DA, Crowson CS, Matteson EL
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1799-1804. Epub 2016 Jun 21 doi: 10.1111/jdv.13760. PMID: 27324138Free PMC Article
Transforming growth factor-beta1 in sarcoidosis.
Salez F, Gosset P, Copin MC, Lamblin Degros C, Tonnel AB, Wallaert B
Eur Respir J 1998 Oct;12(4):913-9. doi: 10.1183/09031936.98.12040913. PMID: 9817168

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