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Liver function tests outside reference range

MedGen UID:
56244
•Concept ID:
C0151766
•
Finding
Synonym: Abnormal liver function tests
SNOMED CT: Abnormal results of liver function studies (166603001); Liver function tests abnormal (166603001); Liver function tests outside reference range (166603001)

Definition

Atypical results found on serum liver enzyme testing, which may indicate significant disease and/or disease progression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver function tests outside reference range

Recent clinical studies

Etiology

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
Yin O, Wagner AJ, Kang J, Knebel W, Zahir H, van de Sande M, Tap WD, Gelderblom H, Healey JH, Shuster D, Stacchiotti S
J Clin Pharmacol 2021 Apr;61(4):480-492. Epub 2020 Oct 11 doi: 10.1002/jcph.1753. PMID: 33043474Free PMC Article
Thromboelastography Better Reflects Hemostatic Abnormalities in Cirrhotics Compared With the International Normalized Ratio.
Hum J, Amador D, Shatzel JJ, Naugler WE, Ahn J, Zaman A, Chang M, Jou JH
J Clin Gastroenterol 2020 Sep;54(8):741-746. doi: 10.1097/MCG.0000000000001285. PMID: 31764489Free PMC Article
Establishing "normal" values for liver function tests after reconstruction of biliary injuries.
Fialkowski EA, Winslow ER, Scott MG, Hawkins WG, Linehan DC, Strasberg SM
J Am Coll Surg 2008 Nov;207(5):705-9. Epub 2008 Aug 30 doi: 10.1016/j.jamcollsurg.2008.07.008. PMID: 18954783
Laboratory parameter profiles among patients with cystic fibrosis.
Goss CH, Mayer-Hamblett N, Kronmal RA, Williams J, Ramsey BW
J Cyst Fibros 2007 Apr;6(2):117-23. Epub 2006 Jul 7 doi: 10.1016/j.jcf.2006.05.012. PMID: 16829217
Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma.
Cantarini MC, Trevisani F, Morselli-Labate AM, Rapaccini G, Farinati F, Del Poggio P, Di Nolfo MA, Benvegnù L, Zoli M, Borzio F, Bernardi M; Italian Liver Cancer (ITA.LI.CA) group
Am J Gastroenterol 2006 Jan;101(1):91-8. doi: 10.1111/j.1572-0241.2006.00364.x. PMID: 16405539

Diagnosis

How Healthy Is Healthy? Comparison Between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects.
Rosenkranz D, Bünger J, Hoffmeyer F, Monsé C, van Kampen V, Raulf M, Brüning T, Sucker K
Adv Exp Med Biol 2020;1271:49-59. doi: 10.1007/5584_2019_472. PMID: 31974924
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H, Pol S
Hepatology 2007 Jul;46(1):32-6. doi: 10.1002/hep.21669. PMID: 17567829
Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma.
Cantarini MC, Trevisani F, Morselli-Labate AM, Rapaccini G, Farinati F, Del Poggio P, Di Nolfo MA, Benvegnù L, Zoli M, Borzio F, Bernardi M; Italian Liver Cancer (ITA.LI.CA) group
Am J Gastroenterol 2006 Jan;101(1):91-8. doi: 10.1111/j.1572-0241.2006.00364.x. PMID: 16405539
Fetal lung-to-liver signal intensity ratio at MR imaging: development of a normal scale and possible role in predicting pulmonary hypoplasia in utero.
Brewerton LJ, Chari RS, Liang Y, Bhargava R
Radiology 2005 Jun;235(3):1005-10. Epub 2005 Apr 21 doi: 10.1148/radiol.2353040280. PMID: 15845789
A preliminary report on urinary BT-PABA/PAS excretion index, serum pancreatic isoamylase and faecal chymotrypsin tests of pancreatic dysfunction in Sowetan Africans.
Chaloner C, Segal I, Hassan H, McIntosh J, Gut A, Rahme M, Braganza JM
Clin Chim Acta 1995 Jan 16;233(1-2):89-99. doi: 10.1016/0009-8981(94)05958-u. PMID: 7758206

Therapy

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
Yin O, Wagner AJ, Kang J, Knebel W, Zahir H, van de Sande M, Tap WD, Gelderblom H, Healey JH, Shuster D, Stacchiotti S
J Clin Pharmacol 2021 Apr;61(4):480-492. Epub 2020 Oct 11 doi: 10.1002/jcph.1753. PMID: 33043474Free PMC Article
How Healthy Is Healthy? Comparison Between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects.
Rosenkranz D, Bünger J, Hoffmeyer F, Monsé C, van Kampen V, Raulf M, Brüning T, Sucker K
Adv Exp Med Biol 2020;1271:49-59. doi: 10.1007/5584_2019_472. PMID: 31974924
Establishing "normal" values for liver function tests after reconstruction of biliary injuries.
Fialkowski EA, Winslow ER, Scott MG, Hawkins WG, Linehan DC, Strasberg SM
J Am Coll Surg 2008 Nov;207(5):705-9. Epub 2008 Aug 30 doi: 10.1016/j.jamcollsurg.2008.07.008. PMID: 18954783
Laboratory parameter profiles among patients with cystic fibrosis.
Goss CH, Mayer-Hamblett N, Kronmal RA, Williams J, Ramsey BW
J Cyst Fibros 2007 Apr;6(2):117-23. Epub 2006 Jul 7 doi: 10.1016/j.jcf.2006.05.012. PMID: 16829217

Prognosis

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
Yin O, Wagner AJ, Kang J, Knebel W, Zahir H, van de Sande M, Tap WD, Gelderblom H, Healey JH, Shuster D, Stacchiotti S
J Clin Pharmacol 2021 Apr;61(4):480-492. Epub 2020 Oct 11 doi: 10.1002/jcph.1753. PMID: 33043474Free PMC Article
Thromboelastography Better Reflects Hemostatic Abnormalities in Cirrhotics Compared With the International Normalized Ratio.
Hum J, Amador D, Shatzel JJ, Naugler WE, Ahn J, Zaman A, Chang M, Jou JH
J Clin Gastroenterol 2020 Sep;54(8):741-746. doi: 10.1097/MCG.0000000000001285. PMID: 31764489Free PMC Article
Establishing "normal" values for liver function tests after reconstruction of biliary injuries.
Fialkowski EA, Winslow ER, Scott MG, Hawkins WG, Linehan DC, Strasberg SM
J Am Coll Surg 2008 Nov;207(5):705-9. Epub 2008 Aug 30 doi: 10.1016/j.jamcollsurg.2008.07.008. PMID: 18954783
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H, Pol S
Hepatology 2007 Jul;46(1):32-6. doi: 10.1002/hep.21669. PMID: 17567829
Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma.
Cantarini MC, Trevisani F, Morselli-Labate AM, Rapaccini G, Farinati F, Del Poggio P, Di Nolfo MA, Benvegnù L, Zoli M, Borzio F, Bernardi M; Italian Liver Cancer (ITA.LI.CA) group
Am J Gastroenterol 2006 Jan;101(1):91-8. doi: 10.1111/j.1572-0241.2006.00364.x. PMID: 16405539

Clinical prediction guides

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
Yin O, Wagner AJ, Kang J, Knebel W, Zahir H, van de Sande M, Tap WD, Gelderblom H, Healey JH, Shuster D, Stacchiotti S
J Clin Pharmacol 2021 Apr;61(4):480-492. Epub 2020 Oct 11 doi: 10.1002/jcph.1753. PMID: 33043474Free PMC Article
Thromboelastography Better Reflects Hemostatic Abnormalities in Cirrhotics Compared With the International Normalized Ratio.
Hum J, Amador D, Shatzel JJ, Naugler WE, Ahn J, Zaman A, Chang M, Jou JH
J Clin Gastroenterol 2020 Sep;54(8):741-746. doi: 10.1097/MCG.0000000000001285. PMID: 31764489Free PMC Article
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H, Pol S
Hepatology 2007 Jul;46(1):32-6. doi: 10.1002/hep.21669. PMID: 17567829
Fetal lung-to-liver signal intensity ratio at MR imaging: development of a normal scale and possible role in predicting pulmonary hypoplasia in utero.
Brewerton LJ, Chari RS, Liang Y, Bhargava R
Radiology 2005 Jun;235(3):1005-10. Epub 2005 Apr 21 doi: 10.1148/radiol.2353040280. PMID: 15845789
A preliminary report on urinary BT-PABA/PAS excretion index, serum pancreatic isoamylase and faecal chymotrypsin tests of pancreatic dysfunction in Sowetan Africans.
Chaloner C, Segal I, Hassan H, McIntosh J, Gut A, Rahme M, Braganza JM
Clin Chim Acta 1995 Jan 16;233(1-2):89-99. doi: 10.1016/0009-8981(94)05958-u. PMID: 7758206

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