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Piezogenic pedal papules

MedGen UID:
538035
•Concept ID:
C0263654
•
Disease or Syndrome
Synonyms: Painful piezogenic pedal papule; Painful piezogenic pedal papules; Piezogenic pedal papule
SNOMED CT: Painful piezogenic pedal papule (50510006); Piezogenic pedal papule (50510006); Painful piezogenic pedal papules (50510006)
 
HPO: HP:0025509

Definition

Flesh-colored or yellowish papules, 2 mm or larger, that are responses to internal mechanical pressure and weakness in the connective tissue in the dermis, appear commonly over the medial aspect of the heel, but in some cases on the wrists. They are thought to represent herniations of adipose tissue through the plantar fascia retinaculum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPiezogenic pedal papules

Conditions with this feature

Ehlers-Danlos syndrome, classic-like, 3
MedGen UID:
1861383
•Concept ID:
C5935631
•
Disease or Syndrome
Ehlers-Danlos syndrome classic-like-3 (EDSCLL3) is an autosomal dominant connective tissue disorder characterized by joint hypermobility and frequent joint dislocations, atrophic scarring, prolonged bleeding time, and age-related aortic dilatation and rupture (Hadar et al., 2024). For a discussion of genetic heterogeneity of classic-like Ehlers-Danlos syndrome, see 606408. For a discussion of the classificiation of Ehlers-Danlos syndrome, see EDSCL1 (130000).
See: Condition Record
Ehlers-Danlos syndrome, classic-like, 3

Recent clinical studies

Etiology

A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.
Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Painful piezogenic pedal papules in patients with Ehlers-Danlos syndrome.
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Diagnosis

A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.
Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Piezogenic pedal papules.
Ma DL, Vano-Galvan S
CMAJ 2013 Dec 10;185(18):E847. Epub 2013 Jun 24 doi: 10.1503/cmaj.121963. PMID: 23798455Free PMC Article
Cutaneous manifestations of disease in athletes.
Bender TW 3rd
Skinmed 2003 Jan-Feb;2(1):34-40. doi: 10.1111/j.1540-9740.2003.01968.x. PMID: 14673322
Piezogenic pedal papules extending into the arch. Case report and discussion.
Pontious J, Lasday S, Mele R
J Am Podiatr Med Assoc 1990 Aug;80(8):444-5. doi: 10.7547/87507315-80-8-444. PMID: 2376836
Painful piezogenic pedal papules in patients with Ehlers-Danlos syndrome.
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Therapy

Cutaneous manifestations of disease in athletes.
Bender TW 3rd
Skinmed 2003 Jan-Feb;2(1):34-40. doi: 10.1111/j.1540-9740.2003.01968.x. PMID: 14673322
Piezogenic pedal papules.
Burkhart CG
Cutis 1984 Jul;34(1):70. PMID: 6467978
Piezogenic pedal papules.
Lebovits PE, Kouskoukis CE, Weidman AI
Cutis 1982 Mar;29(3):276-7, 280. PMID: 7067497
Painful and nonpainful piezogenic pedal papules.
Schlappner OL, Wood MG, Gerstein W, Gross PR
Arch Dermatol 1972 Nov;106(5):729-33. PMID: 4635806
Piezogenic pedal papules.
Grant DJ, Gomez F
Arch Dermatol 1970 May;101(5):619-20. PMID: 5444090

Prognosis

A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.
Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Painful piezogenic pedal papules: response to local electro-acupuncture.
Woodrow SL, Brereton-Smith G, Handfield-Jones S
Br J Dermatol 1997 Apr;136(4):628-30. PMID: 9155975

Clinical prediction guides

A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.
Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Painful piezogenic pedal papules in patients with Ehlers-Danlos syndrome.
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Recent systematic reviews

Alternative Cosmetic and Medical Applications of Injectable Deoxycholic Acid: A Systematic Review.
Liu C, Li MK, Alster TS
Dermatol Surg 2021 Nov 1;47(11):1466-1472. doi: 10.1097/DSS.0000000000003159. PMID: 34537786

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