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Telogen effluvium

MedGen UID:
537938
•Concept ID:
C0263518
•
Disease or Syndrome
Synonyms: Telogen Effluvium; telogen effluvium
SNOMED CT: Telogen effluvium (39479004)
 
HPO: HP:0025470
Monarch Initiative: MONDO:0002153

Definition

A type of hair loss characterized by an abnormal increase in dormant, telogen stage hair follicles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTelogen effluvium

Professional guidelines

PubMed

Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review.
Sharma AN, Michelle L, Juhasz M, Muller Ramos P, Atanaskova Mesinkovska N
Int J Dermatol 2020 Aug;59(8):1013-1019. Epub 2020 Jun 9 doi: 10.1111/ijd.14933. PMID: 32516434
Hair Loss: Common Causes and Treatment.
Phillips TG, Slomiany WP, Allison R
Am Fam Physician 2017 Sep 15;96(6):371-378. PMID: 28925637

Recent clinical studies

Etiology

GLP-1 agonists and hair loss: a call for further investigation.
Desai DD, Sikora M, Nohria A, Bordone L, Caplan AS, Shapiro J, Lo Sicco KI
Int J Dermatol 2024 Sep;63(9):1128-1130. Epub 2024 May 13 doi: 10.1111/ijd.17246. PMID: 38741261
Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study.
Milani M, Colombo F; GFM-O-Trial Investigators Group: Chiara Baraldo (Padova), Mauro Barbareschi (Milano), Paolo Chieco (Ruvo di Puglia), Laura Colonna (Roma), Mandel Victor Desmond (Modena), Maria Cristina Fiorucci (Genova)
Skin Res Technol 2023 Jun;29(6):e13381. doi: 10.1111/srt.13381. PMID: 37357646Free PMC Article
Telogen effluvium caused by COVID-19 in Elmhurst, New York: report of a cohort and review.
Gruenstein D, O'Mara M, Pa SH, Levitt J, Pa SL, Tom J, Leger M
Dermatol Online J 2021 Oct 15;27(10) doi: 10.5070/D3271055619. PMID: 35130383
Psoriatic alopecia.
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Hair loss: an overview.
Mulinari-Brenner F, Bergfeld WF
Dermatol Nurs 2001 Aug;13(4):269-72, 277-8. PMID: 11917783

Diagnosis

GLP-1 agonists and hair loss: a call for further investigation.
Desai DD, Sikora M, Nohria A, Bordone L, Caplan AS, Shapiro J, Lo Sicco KI
Int J Dermatol 2024 Sep;63(9):1128-1130. Epub 2024 May 13 doi: 10.1111/ijd.17246. PMID: 38741261
Medication-induced hair loss: An update.
Alhanshali L, Buontempo M, Shapiro J, Lo Sicco K
J Am Acad Dermatol 2023 Aug;89(2S):S20-S28. doi: 10.1016/j.jaad.2023.04.022. PMID: 37591561
Common causes of hair loss - clinical manifestations, trichoscopy and therapy.
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118
Telogen effluvium.
Grover C, Khurana A
Indian J Dermatol Venereol Leprol 2013 Sep-Oct;79(5):591-603. doi: 10.4103/0378-6323.116731. PMID: 23974577

Therapy

GLP-1 agonists and hair loss: a call for further investigation.
Desai DD, Sikora M, Nohria A, Bordone L, Caplan AS, Shapiro J, Lo Sicco KI
Int J Dermatol 2024 Sep;63(9):1128-1130. Epub 2024 May 13 doi: 10.1111/ijd.17246. PMID: 38741261
Status of research on the development and regeneration of hair follicles.
Liu D, Xu Q, Meng X, Liu X, Liu J
Int J Med Sci 2024;21(1):80-94. Epub 2024 Jan 1 doi: 10.7150/ijms.88508. PMID: 38164355Free PMC Article
Medication-induced hair loss: An update.
Alhanshali L, Buontempo M, Shapiro J, Lo Sicco K
J Am Acad Dermatol 2023 Aug;89(2S):S20-S28. doi: 10.1016/j.jaad.2023.04.022. PMID: 37591561
Minoxidil: a comprehensive review.
Gupta AK, Talukder M, Venkataraman M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1896-1906. Epub 2021 Jul 20 doi: 10.1080/09546634.2021.1945527. PMID: 34159872
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136

Prognosis

Post-COVID Telogen Effluvium.
Tešanović Perković D, Vukojević M, Bukvić Mokos Z
Acta Dermatovenerol Croat 2022 Dec;30(4):220-226. PMID: 36919388
Common causes of hair loss - clinical manifestations, trichoscopy and therapy.
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118
Telogen effluvium revisited.
Rebora A
G Ital Dermatol Venereol 2014 Feb;149(1):47-54. PMID: 24566565
Telogen effluvium.
Harrison S, Sinclair R
Clin Exp Dermatol 2002 Jul;27(5):389-5. doi: 10.1046/j.1365-2230.2002.01080.x. PMID: 12190639

Clinical prediction guides

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study.
Milani M, Colombo F; GFM-O-Trial Investigators Group: Chiara Baraldo (Padova), Mauro Barbareschi (Milano), Paolo Chieco (Ruvo di Puglia), Laura Colonna (Roma), Mandel Victor Desmond (Modena), Maria Cristina Fiorucci (Genova)
Skin Res Technol 2023 Jun;29(6):e13381. doi: 10.1111/srt.13381. PMID: 37357646Free PMC Article
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Trichodynia: a review of the literature.
Rebora A
Int J Dermatol 2016 Apr;55(4):382-4. Epub 2015 Dec 23 doi: 10.1111/ijd.13204. PMID: 26696219
Telogen effluvium revisited.
Rebora A
G Ital Dermatol Venereol 2014 Feb;149(1):47-54. PMID: 24566565
Telogen effluvium.
Harrison S, Sinclair R
Clin Exp Dermatol 2002 Jul;27(5):389-5. doi: 10.1046/j.1365-2230.2002.01080.x. PMID: 12190639

Recent systematic reviews

Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
Chen Y, Dong X, Wang Y, Li Y, Xiong L, Li L
J Cosmet Dermatol 2024 Apr;23(4):1131-1140. Epub 2023 Nov 27 doi: 10.1111/jocd.16093. PMID: 38010941
Chronic Telogen Effluvium: Is it a Distinct Condition? A Systematic Review.
Daunton A, Harries M, Sinclair R, Paus R, Tosti A, Messenger A
Am J Clin Dermatol 2023 Jul;24(4):513-520. Epub 2023 Apr 13 doi: 10.1007/s40257-023-00760-0. PMID: 37052778
A systematic review of acute telogen effluvium, a harrowing post-COVID-19 manifestation.
Hussain N, Agarwala P, Iqbal K, Omar HMS, Jangid G, Patel V, Rathore SS, Kumari C, Velasquez-Botero F, López GAB, Vishwakarma Y, Nipu AP, Ahmed NK
J Med Virol 2022 Apr;94(4):1391-1401. Epub 2021 Dec 28 doi: 10.1002/jmv.27534. PMID: 34931698
Update on trichoscopy: Integration of the terminology by systematic approach and a proposal of a diagnostic flowchart.
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review.
Sharma AN, Michelle L, Juhasz M, Muller Ramos P, Atanaskova Mesinkovska N
Int J Dermatol 2020 Aug;59(8):1013-1019. Epub 2020 Jun 9 doi: 10.1111/ijd.14933. PMID: 32516434

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