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Renal fibrosis

MedGen UID:
508798
•Concept ID:
C0151650
•
Disease or Syndrome
Synonyms: Kidney Fibrosis; Kidney fibrosis; Renal Fibrosis; renal fibrosis
SNOMED CT: Renal fibrosis (197660000)
 
HPO: HP:0030760
Monarch Initiative: MONDO:0000494

Definition

Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease. [from HPO]

Conditions with this feature

Joubert syndrome 35
MedGen UID:
1648453
•Concept ID:
C4748442
•
Disease or Syndrome
Joubert syndrome-35 (JBTS35) is an autosomal recessive disorder characterized by brain malformations that result in developmental delay, oculomotor apraxia, and hypotonia. Some patients have renal and retinal involvement (Alkanderi et al., 2018). For a discussion of genetic heterogeneity of Joubert syndrome, see JBTS1 (213300).
See: Condition Record
Joubert syndrome 35

Professional guidelines

PubMed

Network pharmacology and molecular docking technology-based predictive study of the active ingredients and potential targets of rhubarb for the treatment of diabetic nephropathy.
Fu S, Zhou Y, Hu C, Xu Z, Hou J
BMC Complement Med Ther 2022 Aug 6;22(1):210. doi: 10.1186/s12906-022-03662-6. PMID: 35932042Free PMC Article
Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy.
Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, Zhuang S, Liu N
Cell Death Dis 2020 Jun 17;11(6):467. doi: 10.1038/s41419-020-2673-z. PMID: 32555189Free PMC Article
Update of pathophysiology and management of diabetic kidney disease.
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908

Recent clinical studies

Etiology

Intestinal CXCR6(+) ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression.
Liang Z, Tang Z, Zhu C, Li F, Chen S, Han X, Zheng R, Hu X, Lin R, Pei Q, Yin C, Wang J, Tang C, Cao N, Zhao J, Wang R, Li X, Luo N, Wen Q, Yu J, Li J, Xia X, Zheng X, Wang X, Huang N, Zhong Z, Mo C, Chen P, Wang Y, Fan J, Guo Y, Zhong H, Liu J, Peng Z, Mao H, Shi GP, Bonventre JV, Chen W, Zhou Y
Immunity 2024 Jun 11;57(6):1306-1323.e8. Epub 2024 May 29 doi: 10.1016/j.immuni.2024.05.004. PMID: 38815582Free PMC Article
Iron biology.
Del Vecchio L, Girelli D, Vinchi F, Cozzolino M, Elliott S, Mark PB, Valenti L, Qian C, Guo Q, Qian ZM, Ciceri P, Locatelli F
Nephrol Dial Transplant 2024 Aug 30;39(9):1404-1415. doi: 10.1093/ndt/gfae095. PMID: 38658189
Sex effects in pyelonephritis.
Albracht CD, Hreha TN, Hunstad DA
Pediatr Nephrol 2021 Mar;36(3):507-515. Epub 2020 Feb 10 doi: 10.1007/s00467-020-04492-9. PMID: 32040629Free PMC Article
Mitochondrial dysfunction and the AKI-to-CKD transition.
Jiang M, Bai M, Lei J, Xie Y, Xu S, Jia Z, Zhang A
Am J Physiol Renal Physiol 2020 Dec 1;319(6):F1105-F1116. Epub 2020 Oct 19 doi: 10.1152/ajprenal.00285.2020. PMID: 33073587
Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury.
Su HY, Yang C, Liang D, Liu HF
Biomed Res Int 2020;2020:5817348. Epub 2020 Jun 26 doi: 10.1155/2020/5817348. PMID: 32685502Free PMC Article

Diagnosis

Ferroptosis: an important player in the inflammatory response in diabetic nephropathy.
Li J, Li L, Zhang Z, Chen P, Shu H, Yang C, Chu Y, Liu J
Front Immunol 2023;14:1294317. Epub 2023 Dec 4 doi: 10.3389/fimmu.2023.1294317. PMID: 38111578Free PMC Article
Biomarkers of inflammation and repair in kidney disease progression.
Puthumana J, Thiessen-Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J, Bhatraju PK, Ikizler TA, Siew ED, Ware LB, Liu KD, Go AS, Kaufman JS, Kimmel PL, Chinchilli VM, Cantley LG, Parikh CR
J Clin Invest 2021 Feb 1;131(3) doi: 10.1172/JCI139927. PMID: 33290282Free PMC Article
AKI: an increasingly recognized risk factor for CKD development and progression.
Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H
J Nephrol 2020 Dec;33(6):1171-1187. Epub 2020 Jul 10 doi: 10.1007/s40620-020-00793-2. PMID: 32651850
Update of pathophysiology and management of diabetic kidney disease.
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908
The stiff shoulder in diabetic patients.
Pons-Villanueva J, Escalada San Martín J
Int J Rheum Dis 2016 Dec;19(12):1226-1236. Epub 2016 Jun 16 doi: 10.1111/1756-185X.12890. PMID: 27306701

Therapy

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review.
Alugoju P, Krishna Swamy VKD, Anthikapalli NVA, Tencomnao T
Crit Rev Food Sci Nutr 2023;63(31):10709-10774. Epub 2022 Jun 16 doi: 10.1080/10408398.2022.2084600. PMID: 35708049
Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury.
Yao W, Chen Y, Li Z, Ji J, You A, Jin S, Ma Y, Zhao Y, Wang J, Qu L, Wang H, Xiang C, Wang S, Liu G, Bai F, Yang L
Adv Sci (Weinh) 2022 Apr;9(12):e2103675. Epub 2022 Feb 3 doi: 10.1002/advs.202103675. PMID: 35112806Free PMC Article
Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents.
Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F
Gut 2020 Dec;69(12):2131-2142. Epub 2020 Apr 2 doi: 10.1136/gutjnl-2019-319766. PMID: 32241904Free PMC Article
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways.
Geng XQ, Ma A, He JZ, Wang L, Jia YL, Shao GY, Li M, Zhou H, Lin SQ, Ran JH, Yang BX
Acta Pharmacol Sin 2020 May;41(5):670-677. Epub 2019 Dec 5 doi: 10.1038/s41401-019-0324-7. PMID: 31804606Free PMC Article
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
Li R, Guo Y, Zhang Y, Zhang X, Zhu L, Yan T
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051103. PMID: 30836660Free PMC Article

Prognosis

Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan.
Kadowaki T, Maegawa H, Watada H, Yabe D, Node K, Murohara T, Wada J
Diabetes Obes Metab 2022 Dec;24(12):2283-2296. Epub 2022 Aug 25 doi: 10.1111/dom.14829. PMID: 35929483Free PMC Article
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV
Cell Metab 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465Free PMC Article
Cellular Senescence in the Kidney.
Docherty MH, O'Sullivan ED, Bonventre JV, Ferenbach DA
J Am Soc Nephrol 2019 May;30(5):726-736. Epub 2019 Apr 18 doi: 10.1681/ASN.2018121251. PMID: 31000567Free PMC Article
The stiff shoulder in diabetic patients.
Pons-Villanueva J, Escalada San Martín J
Int J Rheum Dis 2016 Dec;19(12):1226-1236. Epub 2016 Jun 16 doi: 10.1111/1756-185X.12890. PMID: 27306701
Cellular and molecular mechanisms of renal fibrosis.
Liu Y
Nat Rev Nephrol 2011 Oct 18;7(12):684-96. doi: 10.1038/nrneph.2011.149. PMID: 22009250Free PMC Article

Clinical prediction guides

Intestinal CXCR6(+) ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression.
Liang Z, Tang Z, Zhu C, Li F, Chen S, Han X, Zheng R, Hu X, Lin R, Pei Q, Yin C, Wang J, Tang C, Cao N, Zhao J, Wang R, Li X, Luo N, Wen Q, Yu J, Li J, Xia X, Zheng X, Wang X, Huang N, Zhong Z, Mo C, Chen P, Wang Y, Fan J, Guo Y, Zhong H, Liu J, Peng Z, Mao H, Shi GP, Bonventre JV, Chen W, Zhou Y
Immunity 2024 Jun 11;57(6):1306-1323.e8. Epub 2024 May 29 doi: 10.1016/j.immuni.2024.05.004. PMID: 38815582Free PMC Article
Role of mitochondria in pathogenesis and therapy of renal fibrosis.
Zhao X, Li Y, Yu J, Teng H, Wu S, Wang Y, Zhou H, Li F
Metabolism 2024 Jun;155:155913. Epub 2024 Apr 11 doi: 10.1016/j.metabol.2024.155913. PMID: 38609039
Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments.
Martínez-Klimova E, Aparicio-Trejo OE, Tapia E, Pedraza-Chaverri J
Biomolecules 2019 Apr 8;9(4) doi: 10.3390/biom9040141. PMID: 30965656Free PMC Article
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.
Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K
Nat Med 2015 Jan;21(1):37-46. Epub 2014 Dec 1 doi: 10.1038/nm.3762. PMID: 25419705Free PMC Article
Cellular and molecular mechanisms of renal fibrosis.
Liu Y
Nat Rev Nephrol 2011 Oct 18;7(12):684-96. doi: 10.1038/nrneph.2011.149. PMID: 22009250Free PMC Article

Recent systematic reviews

Relationship between ferroptosis and mitophagy in renal fibrosis: a systematic review.
Zhang M, Tong Z, Wang Y, Fu W, Meng Y, Huang J, Sun L
J Drug Target 2023 Sep;31(8):858-866. Epub 2023 Aug 23 doi: 10.1080/1061186X.2023.2250574. PMID: 37607069
Shear Wave Elastography for Assessment of Biopsy-Proven Renal Fibrosis: A Systematic Review and Meta-analysis.
Cao H, Ke B, Lin F, Xue Y, Fang X
Ultrasound Med Biol 2023 May;49(5):1037-1048. Epub 2023 Feb 4 doi: 10.1016/j.ultrasmedbio.2023.01.003. PMID: 36746743
Serum Biomarkers of Renal Fibrosis: A Systematic Review.
Barinotti A, Radin M, Cecchi I, Foddai SG, Rubini E, Roccatello D, Sciascia S
Int J Mol Sci 2022 Nov 16;23(22) doi: 10.3390/ijms232214139. PMID: 36430625Free PMC Article
Identification of candidate lncRNA biomarkers for renal fibrosis: A systematic review.
Jia H, Ma T, Hao C
Life Sci 2020 Dec 1;262:118566. Epub 2020 Oct 8 doi: 10.1016/j.lfs.2020.118566. PMID: 33038373
Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review.
Mansour SG, Puthumana J, Coca SG, Gentry M, Parikh CR
BMC Nephrol 2017 Feb 20;18(1):72. doi: 10.1186/s12882-017-0490-0. PMID: 28219345Free PMC Article

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