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Myelomonocytic leukemia

MedGen UID:
507961
•Concept ID:
C0027019
•
Neoplastic Process
SNOMED CT: Myelomonocytic leukemia (188768003); Myelomonocytic leukemia (1163590002)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyelomonocytic leukemia

Professional guidelines

PubMed

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article

Recent clinical studies

Etiology

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.
Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR
Virchows Arch 2023 Jan;482(1):113-130. Epub 2022 Nov 29 doi: 10.1007/s00428-022-03447-9. PMID: 36445482
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Neonatal Leukemia.
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502

Diagnosis

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.
Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR
Virchows Arch 2023 Jan;482(1):113-130. Epub 2022 Nov 29 doi: 10.1007/s00428-022-03447-9. PMID: 36445482
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Leukemia Cutis.
Barry D, Schmieder A
N Engl J Med 2021 Sep 30;385(14):1316. doi: 10.1056/NEJMicm2103771. PMID: 34587388

Therapy

Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel.
de Witte T, Bowen D, Robin M, Malcovati L, Niederwieser D, Yakoub-Agha I, Mufti GJ, Fenaux P, Sanz G, Martino R, Alessandrino EP, Onida F, Symeonidis A, Passweg J, Kobbe G, Ganser A, Platzbecker U, Finke J, van Gelder M, van de Loosdrecht AA, Ljungman P, Stauder R, Volin L, Deeg HJ, Cutler C, Saber W, Champlin R, Giralt S, Anasetti C, Kröger N
Blood 2017 Mar 30;129(13):1753-1762. Epub 2017 Jan 17 doi: 10.1182/blood-2016-06-724500. PMID: 28096091Free PMC Article
Childhood leukemia.
Hutter JJ
Pediatr Rev 2010 Jun;31(6):234-41. doi: 10.1542/pir.31-6-234. PMID: 20516235
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596
Juvenile myelomonocytic leukemia.
Aricò M, Biondi A, Pui CH
Blood 1997 Jul 15;90(2):479-88. PMID: 9226148

Prognosis

Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study.
Kurosawa S, Shimomura Y, Ishiyama K, Fuse K, Shimazu Y, Doki N, Uchida N, Tanaka M, Takahashi S, Sakurai M, Kobayashi H, Katayama Y, Takada S, Ozeki K, Nakamae H, Ishimaru F, Kanda Y, Ichinohe T, Atsuta Y, Itonaga H
Bone Marrow Transplant 2024 Jun;59(6):742-750. Epub 2024 Feb 8 doi: 10.1038/s41409-024-02223-4. PMID: 38331981
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic myelomonocytic leukemia prognostic classification and management: evidence base and current practice.
Selimoglu-Buet D, Solary E
Curr Hematol Malig Rep 2014 Dec;9(4):301-10. doi: 10.1007/s11899-014-0225-2. PMID: 25142910
Childhood leukemia.
Hutter JJ
Pediatr Rev 2010 Jun;31(6):234-41. doi: 10.1542/pir.31-6-234. PMID: 20516235
Juvenile myelomonocytic leukemia.
Aricò M, Biondi A, Pui CH
Blood 1997 Jul 15;90(2):479-88. PMID: 9226148

Clinical prediction guides

LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia.
Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El Haddad A, Kogan SC, Abdullaev Z, Chehab FF, Tasian SK, Smith CC, Loh ML, Stieglitz E
Haematologica 2024 Aug 1;109(8):2533-2541. doi: 10.3324/haematol.2023.283776. PMID: 38152053Free PMC Article
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Genetic complexity of chronic myelomonocytic leukemia.
Patel AB, Deininger MW
Leuk Lymphoma 2021 May;62(5):1031-1045. Epub 2020 Dec 18 doi: 10.1080/10428194.2020.1856837. PMID: 33337259
Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel.
de Witte T, Bowen D, Robin M, Malcovati L, Niederwieser D, Yakoub-Agha I, Mufti GJ, Fenaux P, Sanz G, Martino R, Alessandrino EP, Onida F, Symeonidis A, Passweg J, Kobbe G, Ganser A, Platzbecker U, Finke J, van Gelder M, van de Loosdrecht AA, Ljungman P, Stauder R, Volin L, Deeg HJ, Cutler C, Saber W, Champlin R, Giralt S, Anasetti C, Kröger N
Blood 2017 Mar 30;129(13):1753-1762. Epub 2017 Jan 17 doi: 10.1182/blood-2016-06-724500. PMID: 28096091Free PMC Article
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Recent systematic reviews

Investigating historic cases of pyoderma gangrenosum in myelodysplastic syndrome and chronic myelomonocytic leukemia for possible VEXAS syndrome: A systematic review.
Croitoru DO, Huang RS, McMullen EP, Maazi M, Piguet V
J Am Acad Dermatol 2024 Oct;91(4):712-714. Epub 2024 Jun 19 doi: 10.1016/j.jaad.2024.05.086. PMID: 38906261
CSF3R-mutant chronic myelomonocytic leukemia is a distinct clinically subset with abysmal prognosis: a case report and systematic review of the literature.
Guastafierro V, Ubezio M, Manes N, Milanesi C, Della Porta M, Bonometti A
Leuk Lymphoma 2023 Sep;64(9):1566-1573. Epub 2023 Jul 3 doi: 10.1080/10428194.2023.2227750. PMID: 37395413
Hypomethylating agents in the treatment of chronic myelomonocytic leukemia: a meta-analysis and systematic review.
Xu R, Li M, Wu P, Deng C, Geng S, Huang X, Weng J, Du X
Hematology 2021 Dec;26(1):312-320. doi: 10.1080/16078454.2021.1875600. PMID: 33706667
A systematic review and meta-analysis of the efficacy and adverse events of azacitidine-plus-lenalidomide treatment for patients with acute myeloid leukemia, myelodysplastic syndromes and chronic myelomonocytic leukemia (1).
Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Systematic Literature Review of Treatment Options and Clinical Outcomes for Patients With Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia.
Bell JA, Galaznik A, Huelin R, Stokes M, Guo Y, Fram RJ, Faller DV
Clin Lymphoma Myeloma Leuk 2018 Apr;18(4):e157-e166. Epub 2018 Feb 8 doi: 10.1016/j.clml.2018.02.001. PMID: 29475821

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