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Cleft maxillary alveolar ridge

MedGen UID:
488995
Concept ID:
C2919907
Congenital Abnormality
Synonym: Cleft of alveolar ridge of maxilla
SNOMED CT: Cleft of alveolar ridge (445306000)
 
HPO: HP:0010289

Definition

A gap (cleft) affecting one of the alveolar ridges, which are the protuberances in the mouth that contain the sockets (alveoli) of the teeth. An alveolar cleft can affect all structures of the alveolar ridge, including the gingiva, other mucosa, periosteum, alveolar bone, and teeth. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine. [from HPO]

Conditions with this feature

Anencephaly 2
MedGen UID:
1794155
Concept ID:
C5561945
Congenital Abnormality
Anencephaly-2 (ANPH2) is a severe neural tube defect caused by failure of neural tube closure anteriorly. Features in addition to anencephaly may include frontonasal dysplasia with midline cleft of the upper lip and alveolar ridge, bifid nose, and clinical anophthalmia. For a discussion of genetic heterogeneity of anencephaly, see ANPH1 (206500).

Professional guidelines

PubMed

Santiago PE, Schuster LA, Levy-Bercowski D
Clin Plast Surg 2014 Apr;41(2):219-32. doi: 10.1016/j.cps.2014.01.001. PMID: 24607190
Robertson NR
Br Dent J 1978 Oct 17;145(8):236-40. doi: 10.1038/sj.bdj.4804155. PMID: 279346
O'Donnell JP, Krischer JP, Shiere FR
Cleft Palate J 1974 Oct;11:374-93. PMID: 4530750

Recent clinical studies

Etiology

Park JJ, Rochlin DH, Parsaei Y, Shetye PR, Witek L, Leucht P, Rabbani PS, Flores RL
Cleft Palate Craniofac J 2023 Nov;60(11):1450-1461. Epub 2022 Jun 9 doi: 10.1177/10556656221104954. PMID: 35678607
Kramer FJ, Baethge C, Swennen G, Teltzrow T, Schulze A, Berten J, Brachvogel P
J Craniofac Surg 2004 Nov;15(6):971-7; discussion 978-9. doi: 10.1097/00001665-200411000-00016. PMID: 15547385
Piette E, Alberius P, Samman N, Linde A
Int J Oral Maxillofac Surg 1995 Oct;24(5):327-32. doi: 10.1016/s0901-5027(05)80483-7. PMID: 8627094
Freihofer HP Jr
J Maxillofac Surg 1977 Feb;5(1):20-7. doi: 10.1016/s0301-0503(77)80071-4. PMID: 265348
Freihofer HP Jr
J Maxillofac Surg 1976 May 1;4(3):136-41. PMID: 1066412

Diagnosis

Padisar P, Tofangchiha M, Salari B, Oveisi S
Cleft Palate Craniofac J 2021 Feb;58(2):202-207. Epub 2020 Aug 12 doi: 10.1177/1055665620946980. PMID: 32783463
Wilson AT, Wu RT, Sawh-Martinez R, Steinbacher DM
J Oral Maxillofac Surg 2019 Apr;77(4):850.e1-850.e5. Epub 2018 Nov 26 doi: 10.1016/j.joms.2018.11.011. PMID: 30576673
Lakshmy SR, Deepa S, Rose N, Mookan S, Agnees J
J Ultrasound Med 2017 Jul;36(7):1397-1414. Epub 2017 Apr 18 doi: 10.7863/ultra.16.05084. PMID: 28417474
Rahpeyma A, Khajehahmadi S
Br J Oral Maxillofac Surg 2015 Jan;53(1):99-101. Epub 2014 Nov 8 doi: 10.1016/j.bjoms.2014.09.019. PMID: 25445388
Kim SM, Lee YJ, Lee SS, Kim YS, Lee SK, Kim IB, Chi JG
Cleft Palate Craniofac J 2008 Mar;45(2):131-40. doi: 10.1597/06-077.1. PMID: 18333644

Therapy

Liang F, Leland H, Jedrzejewski B, Auslander A, Maniskas S, Swanson J, Urata M, Hammoudeh J, Magee W 3rd
J Craniofac Surg 2018 May;29(3):584-593. doi: 10.1097/SCS.0000000000004300. PMID: 29461365
Amodeo G, Scopelliti D
J Craniofac Surg 2018 Mar;29(2):e126-e128. doi: 10.1097/SCS.0000000000004135. PMID: 29215438
Kramer FJ, Baethge C, Swennen G, Teltzrow T, Schulze A, Berten J, Brachvogel P
J Craniofac Surg 2004 Nov;15(6):971-7; discussion 978-9. doi: 10.1097/00001665-200411000-00016. PMID: 15547385
Piette E, Alberius P, Samman N, Linde A
Int J Oral Maxillofac Surg 1995 Oct;24(5):327-32. doi: 10.1016/s0901-5027(05)80483-7. PMID: 8627094
Lynch JB, Wisner HK, Evans RM, Barnett R, Lewis SR
Plast Reconstr Surg 1970 Dec;46(6):564-7. doi: 10.1097/00006534-197012000-00005. PMID: 5493026

Prognosis

Gibson CF, Mandelaris GA
Dent Clin North Am 2015 Jul;59(3):733-53. doi: 10.1016/j.cden.2015.03.011. PMID: 26140978
Piette E, Alberius P, Samman N, Linde A
Int J Oral Maxillofac Surg 1995 Oct;24(5):327-32. doi: 10.1016/s0901-5027(05)80483-7. PMID: 8627094
Freihofer HP, van Damme PA, Kuijpers-Jagtman AM
J Craniomaxillofac Surg 1991 Jan;19(1):2-6. doi: 10.1016/s1010-5182(05)80264-1. PMID: 2019655
Ortiz Monasterio F, Medina O, Musolas A
Plast Reconstr Surg 1990 Oct;86(4):650-7. doi: 10.1097/00006534-199010000-00005. PMID: 2217578
Friede H, Johanson B
Scand J Plast Reconstr Surg 1974;8(1-2):88-103. doi: 10.3109/02844317409084377. PMID: 4615373

Clinical prediction guides

Tankittiwat P, Pisek A, Manosudprasit M, Punyavong P, Manosudprasit A, Phaoseree N, Wangsrimongkol B, Pisek P, Manosudprasit A
Cleft Palate Craniofac J 2021 Nov;58(11):1389-1397. Epub 2021 Mar 4 doi: 10.1177/1055665621990184. PMID: 33657892
Saad MS, Fata M, Farouk A, Habib AMA, Gad M, Tayel MB, Marei MK
JDR Clin Trans Res 2020 Oct;5(4):319-331. Epub 2019 Dec 20 doi: 10.1177/2380084419887336. PMID: 31860800
Wilson AT, Wu RT, Sawh-Martinez R, Steinbacher DM
J Oral Maxillofac Surg 2019 Apr;77(4):850.e1-850.e5. Epub 2018 Nov 26 doi: 10.1016/j.joms.2018.11.011. PMID: 30576673
Zuk PA
Pediatr Res 2008 May;63(5):478-86. doi: 10.1203/PDR.0b013e31816bdf36. PMID: 18427291
Ortiz Monasterio F, Medina O, Musolas A
Plast Reconstr Surg 1990 Oct;86(4):650-7. doi: 10.1097/00006534-199010000-00005. PMID: 2217578

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