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Thyrotoxicosis with diffuse goiter

MedGen UID:
488851
•Concept ID:
C0342122
•
Disease or Syndrome
Synonym: Toxic diffuse goiter
SNOMED CT: Toxic diffuse thyroid goiter (267374005); Toxic primary thyroid hyperplasia (267374005); Thyrotoxicosis with diffuse goiter (267374005); Toxic diffuse goiter (267374005); Diffuse toxic goiter (267374005)
 
HPO: HP:0011784
Monarch Initiative: MONDO:0001104

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyrotoxicosis with diffuse goiter

Professional guidelines

PubMed

Current approach to surgical management of hyperthyroidism.
Barczyński M
Q J Nucl Med Mol Imaging 2021 Jun;65(2):124-131. Epub 2021 Jan 26 doi: 10.23736/S1824-4785.21.03330-6. PMID: 33494587
Management of thyrotoxicosis in children and adolescents: 35 years' experience in 304 patients.
Azizi F, Amouzegar A
J Pediatr Endocrinol Metab 2018 Jan 26;31(2):159-165. doi: 10.1515/jpem-2017-0394. PMID: 29306930
Thyroid masses: approach to diagnosis and management in childhood and adolescence.
Hopwood NJ, Kelch RP
Pediatr Rev 1993 Dec;14(12):481-7. PMID: 8115286

Curated

UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

Recent clinical studies

Etiology

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Current approach to surgical management of hyperthyroidism.
Barczyński M
Q J Nucl Med Mol Imaging 2021 Jun;65(2):124-131. Epub 2021 Jan 26 doi: 10.23736/S1824-4785.21.03330-6. PMID: 33494587
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
The elderly and thyrotoxicosis.
McMorrow ME
AACN Clin Issues Crit Care Nurs 1992 Feb;3(1):114-9. doi: 10.4037/15597768-1992-1014. PMID: 1554551

Diagnosis

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Molecular Imaging for Thyrotoxicosis and Thyroid Nodules.
Giovanella L, Avram A, Clerc J
J Nucl Med 2021 Jul;62(Suppl 2):20S-25S. doi: 10.2967/jnumed.120.246017. PMID: 34230069
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Diagnostic imaging in thyrotoxicosis.
Summaria V, Salvatori M, Rufini V, Mirk P, Garganese MC, Romani M
Rays 1999 Apr-Jun;24(2):273-300. PMID: 10509131
Central hyperthyroidism.
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036

Therapy

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
A 62-Year-Old Woman With Diffuse Myalgias, Fatigue, and Shortness of Breath.
Park BD, Lyn-Kew K, Granchelli A, Mehta A
Chest 2020 Mar;157(3):e75-e78. doi: 10.1016/j.chest.2019.09.041. PMID: 32145820
Hashimoto's thyroiditis and the role of selenium. Current concepts.
Mazokopakis EE, Chatzipavlidou V
Hell J Nucl Med 2007 Jan-Apr;10(1):6-8. PMID: 17450242
The safety and efficacy of antithyroid drugs.
Azizi F
Expert Opin Drug Saf 2006 Jan;5(1):107-16. doi: 10.1517/14740338.5.1.107. PMID: 16370960
Thyrotoxicosis during pregnancy.
Pekonen F, Lamberg BA
Ann Chir Gynaecol 1978;67(5):165-73. PMID: 84547

Prognosis

Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
A 62-Year-Old Woman With Diffuse Myalgias, Fatigue, and Shortness of Breath.
Park BD, Lyn-Kew K, Granchelli A, Mehta A
Chest 2020 Mar;157(3):e75-e78. doi: 10.1016/j.chest.2019.09.041. PMID: 32145820
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
The safety and efficacy of antithyroid drugs.
Azizi F
Expert Opin Drug Saf 2006 Jan;5(1):107-16. doi: 10.1517/14740338.5.1.107. PMID: 16370960

Clinical prediction guides

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Study and Correlation of Clinical, Laboratory and Radiological Findings in the Diagnosis of Thyroid Disorders.
Upadhyay I, Kukrele P
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443327
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
T4-thyrotoxicosis.
Dorfman SG, Young RL
Arch Intern Med 1978 Jun;138(6):1016-7. PMID: 580554

Recent systematic reviews

A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis.
Varadharajan K, Choudhury N
Clin Otolaryngol 2020 Jul;45(4):538-544. Epub 2020 Apr 20 doi: 10.1111/coa.13527. PMID: 32149464

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

    Consumer resources

    Reviews

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