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Bacterial pneumonia

MedGen UID:
484
•Concept ID:
C0004626
•
Disease or Syndrome
Synonyms: Bacterial Pneumonia; Bacterial Pneumonias; Pneumonia, Bacterial; Pneumonias, Bacterial
SNOMED CT: Bacterial pneumonia (53084003)
 
Monarch Initiative: MONDO:0004652

Definition

Acute infection of the lung parenchyma caused by bacteria (e.g., Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila). Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. [from NCI]

Professional guidelines

PubMed

ARDS clinical practice guideline 2021.
Tasaka S, Ohshimo S, Takeuchi M, Yasuda H, Ichikado K, Tsushima K, Egi M, Hashimoto S, Shime N, Saito O, Matsumoto S, Nango E, Okada Y, Hayashi K, Sakuraya M, Nakajima M, Okamori S, Miura S, Fukuda T, Ishihara T, Kamo T, Yatabe T, Norisue Y, Aoki Y, Iizuka Y, Kondo Y, Narita C, Kawakami D, Okano H, Takeshita J, Anan K, Okazaki SR, Taito S, Hayashi T, Mayumi T, Terayama T, Kubota Y, Abe Y, Iwasaki Y, Kishihara Y, Kataoka J, Nishimura T, Yonekura H, Ando K, Yoshida T, Masuyama T, Sanui M; ARDS Clinical Practice Guideline Committee 2021 from the Japanese Respiratory Society, the Japanese Society of Intensive Care Medicine, and the Japanese Society of Respiratory Care Medicine
Respir Investig 2022 Jul;60(4):446-495. Epub 2022 Jun 24 doi: 10.1016/j.resinv.2022.05.003. PMID: 35753956
Atypical pneumonia: Pathophysiology, diagnosis, and treatment.
Miyashita N
Respir Investig 2022 Jan;60(1):56-67. Epub 2021 Nov 5 doi: 10.1016/j.resinv.2021.09.009. PMID: 34750083
Management of Pediatric Community-acquired Bacterial Pneumonia.
Messinger AI, Kupfer O, Hurst A, Parker S
Pediatr Rev 2017 Sep;38(9):394-409. doi: 10.1542/pir.2016-0183. PMID: 28864731

Recent clinical studies

Etiology

Community-acquired bacterial pneumonia in adults: An update.
Eshwara VK, Mukhopadhyay C, Rello J
Indian J Med Res 2020 Apr;151(4):287-302. doi: 10.4103/ijmr.IJMR_1678_19. PMID: 32461392Free PMC Article
Omadacycline for Community-Acquired Bacterial Pneumonia.
Stets R, Popescu M, Gonong JR, Mitha I, Nseir W, Madej A, Kirsch C, Das AF, Garrity-Ryan L, Steenbergen JN, Manley A, Eckburg PB, Tzanis E, McGovern PC, Loh E
N Engl J Med 2019 Feb 7;380(6):517-527. doi: 10.1056/NEJMoa1800201. PMID: 30726692
Bacterial Pneumonia in Older Adults.
Henig O, Kaye KS
Infect Dis Clin North Am 2017 Dec;31(4):689-713. Epub 2017 Sep 13 doi: 10.1016/j.idc.2017.07.015. PMID: 28916385Free PMC Article
Pathophysiology of pneumonia.
Alcón A, Fàbregas N, Torres A
Clin Chest Med 2005 Mar;26(1):39-46. doi: 10.1016/j.ccm.2004.10.013. PMID: 15802164
Ventilator-associated pneumonia.
Vincent JL
J Hosp Infect 2004 Aug;57(4):272-80. doi: 10.1016/j.jhin.2003.06.001. PMID: 15262388

Diagnosis

Influenza and Viral Pneumonia.
Cavallazzi R, Ramirez JA
Infect Dis Clin North Am 2024 Mar;38(1):183-212. doi: 10.1016/j.idc.2023.12.010. PMID: 38280763
Antibacterial drugs for community-acquired pneumonia.
Med Lett Drugs Ther 2021 Jan 25;63(1616):10-14. PMID: 33512346
Community-acquired bacterial pneumonia in adults: An update.
Eshwara VK, Mukhopadhyay C, Rello J
Indian J Med Res 2020 Apr;151(4):287-302. doi: 10.4103/ijmr.IJMR_1678_19. PMID: 32461392Free PMC Article
Bacterial Pneumonia in Older Adults.
Henig O, Kaye KS
Infect Dis Clin North Am 2017 Dec;31(4):689-713. Epub 2017 Sep 13 doi: 10.1016/j.idc.2017.07.015. PMID: 28916385Free PMC Article
Management of Pediatric Community-acquired Bacterial Pneumonia.
Messinger AI, Kupfer O, Hurst A, Parker S
Pediatr Rev 2017 Sep;38(9):394-409. doi: 10.1542/pir.2016-0183. PMID: 28864731

Therapy

Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii-calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK).
Kaye KS, Shorr AF, Wunderink RG, Du B, Poirier GE, Rana K, Miller A, Lewis D, O'Donnell J, Chen L, Reinhart H, Srinivasan S, Isaacs R, Altarac D
Lancet Infect Dis 2023 Sep;23(9):1072-1084. Epub 2023 May 11 doi: 10.1016/S1473-3099(23)00184-6. PMID: 37182534
Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
Saleem N, Kulkarni A, Snow TAC, Ambler G, Singer M, Arulkumaran N
Chest 2023 Mar;163(3):484-497. Epub 2022 Sep 7 doi: 10.1016/j.chest.2022.08.2229. PMID: 36087797Free PMC Article
Ceftaroline.
Soriano A
Rev Esp Quimioter 2021 Sep;34 Suppl 1(Suppl1):29-31. Epub 2021 Sep 30 doi: 10.37201/req/s01.08.2021. PMID: 34598420Free PMC Article
Omadacycline for Community-Acquired Bacterial Pneumonia.
Stets R, Popescu M, Gonong JR, Mitha I, Nseir W, Madej A, Kirsch C, Das AF, Garrity-Ryan L, Steenbergen JN, Manley A, Eckburg PB, Tzanis E, McGovern PC, Loh E
N Engl J Med 2019 Feb 7;380(6):517-527. doi: 10.1056/NEJMoa1800201. PMID: 30726692
Corticosteroids for pneumonia.
Stern A, Skalsky K, Avni T, Carrara E, Leibovici L, Paul M
Cochrane Database Syst Rev 2017 Dec 13;12(12):CD007720. doi: 10.1002/14651858.CD007720.pub3. PMID: 29236286Free PMC Article

Prognosis

Bacterial Pneumonia in Older Adults.
Marrie TJ, File TM Jr
Clin Geriatr Med 2016 Aug;32(3):459-77. Epub 2016 Apr 20 doi: 10.1016/j.cger.2016.02.012. PMID: 27394017
Community-acquired pneumonia.
Stein RT, Marostica PJ
Paediatr Respir Rev 2006;7 Suppl 1:S136-7. Epub 2006 Jun 6 doi: 10.1016/j.prrv.2006.04.221. PMID: 16798540
Ventilator-associated pneumonia.
Vincent JL
J Hosp Infect 2004 Aug;57(4):272-80. doi: 10.1016/j.jhin.2003.06.001. PMID: 15262388
Pediatric ventilator-associated pneumonia.
Elward AM
Pediatr Infect Dis J 2003 May;22(5):445-6. doi: 10.1097/01.inf.0000069000.67615.bd. PMID: 12792388
Pyogenic lung infections.
Mwandumba HC, Beeching NJ
Curr Opin Pulm Med 1999 May;5(3):151-6. doi: 10.1097/00063198-199905000-00005. PMID: 10228739

Clinical prediction guides

The causal relationship between bacterial pneumonia and diabetes: a two-sample mendelian randomization study.
Pan S, Zhang Z, Pang W
Islets 2024 Dec 31;16(1):2291885. Epub 2023 Dec 14 doi: 10.1080/19382014.2023.2291885. PMID: 38095344Free PMC Article
Community-acquired bacterial pneumonia in adults: An update.
Eshwara VK, Mukhopadhyay C, Rello J
Indian J Med Res 2020 Apr;151(4):287-302. doi: 10.4103/ijmr.IJMR_1678_19. PMID: 32461392Free PMC Article
The pathology of pulmonary bacterial infection.
Kradin RL, Digumarthy S
Semin Diagn Pathol 2017 Nov;34(6):498-509. Epub 2017 Jun 7 doi: 10.1053/j.semdp.2017.06.001. PMID: 28655479
Bacterial Pneumonia in Older Adults.
Marrie TJ, File TM Jr
Clin Geriatr Med 2016 Aug;32(3):459-77. Epub 2016 Apr 20 doi: 10.1016/j.cger.2016.02.012. PMID: 27394017
Community-acquired pneumonia.
Remington LT, Sligl WI
Curr Opin Pulm Med 2014 May;20(3):215-24. doi: 10.1097/MCP.0000000000000052. PMID: 24614242

Recent systematic reviews

Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
Saleem N, Kulkarni A, Snow TAC, Ambler G, Singer M, Arulkumaran N
Chest 2023 Mar;163(3):484-497. Epub 2022 Sep 7 doi: 10.1016/j.chest.2022.08.2229. PMID: 36087797Free PMC Article
ARDS clinical practice guideline 2021.
Tasaka S, Ohshimo S, Takeuchi M, Yasuda H, Ichikado K, Tsushima K, Egi M, Hashimoto S, Shime N, Saito O, Matsumoto S, Nango E, Okada Y, Hayashi K, Sakuraya M, Nakajima M, Okamori S, Miura S, Fukuda T, Ishihara T, Kamo T, Yatabe T, Norisue Y, Aoki Y, Iizuka Y, Kondo Y, Narita C, Kawakami D, Okano H, Takeshita J, Anan K, Okazaki SR, Taito S, Hayashi T, Mayumi T, Terayama T, Kubota Y, Abe Y, Iwasaki Y, Kishihara Y, Kataoka J, Nishimura T, Yonekura H, Ando K, Yoshida T, Masuyama T, Sanui M; ARDS Clinical Practice Guideline Committee 2021 from the Japanese Respiratory Society, the Japanese Society of Intensive Care Medicine, and the Japanese Society of Respiratory Care Medicine
Respir Investig 2022 Jul;60(4):446-495. Epub 2022 Jun 24 doi: 10.1016/j.resinv.2022.05.003. PMID: 35753956
Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections. A systematic review and meta-analysis.
Gentilotti E, De Nardo P, Cremonini E, Górska A, Mazzaferri F, Canziani LM, Hellou MM, Olchowski Y, Poran I, Leeflang M, Villacian J, Goossens H, Paul M, Tacconelli E
Clin Microbiol Infect 2022 Jan;28(1):13-22. Epub 2021 Oct 1 doi: 10.1016/j.cmi.2021.09.025. PMID: 34601148
Corticosteroids for pneumonia.
Stern A, Skalsky K, Avni T, Carrara E, Leibovici L, Paul M
Cochrane Database Syst Rev 2017 Dec 13;12(12):CD007720. doi: 10.1002/14651858.CD007720.pub3. PMID: 29236286Free PMC Article
Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis.
Hogerwerf L, DE Gier B, Baan B, VAN DER Hoek W
Epidemiol Infect 2017 Nov;145(15):3096-3105. Epub 2017 Sep 26 doi: 10.1017/S0950268817002060. PMID: 28946931Free PMC Article

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