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Adult Extramedullary Hematopoiesis

MedGen UID:
474857
•Concept ID:
C3273224
•
Finding

Definition

Extramedullary hematopoiesis occurring during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Extramedullary Hematopoiesis

Professional guidelines

PubMed

Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Bianchi P, Fermo E, Lezon-Geyda K, van Beers EJ, Morton HD, Barcellini W, Glader B, Chonat S, Ravindranath Y, Newburger PE, Kollmar N, Despotovic JM, Verhovsek M, Sharma M, Kwiatkowski JL, Kuo KHM, Wlodarski MW, Yaish HM, Holzhauer S, Wang H, Kunz J, Addonizio K, Al-Sayegh H, London WB, Andres O, van Wijk R, Gallagher PG, Grace RFF
Am J Hematol 2020 May;95(5):472-482. Epub 2020 Mar 6 doi: 10.1002/ajh.25753. PMID: 32043619Free PMC Article
Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment.
Khalil S, Ariel Gru A, Saavedra AP
Exp Dermatol 2019 Nov;28(11):1201-1209. Epub 2019 Aug 23 doi: 10.1111/exd.14013. PMID: 31351011

Recent clinical studies

Etiology

Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective.
Savani M, Dulery R, Bazarbachi AH, Mohty R, Brissot E, Malard F, Bazarbachi A, Nagler A, Mohty M
Br J Haematol 2021 Nov;195(4):495-506. Epub 2021 Apr 21 doi: 10.1111/bjh.17469. PMID: 33881169
Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: a closer look at the role of siderosis.
Maakaron JE, Cappellini MD, Graziadei G, Ayache JB, Taher AT
Ann Hepatol 2013 Jan-Feb;12(1):142-6. PMID: 23293206
Liver morphologic analysis in perinatal autopsies with intrauterine stress liver morphology in perinatal autopsies.
Oliveira LF, da Silva Monteiro AP, Espindula AP, Morais Pereira LH, Rocha LP, de Oliveira Guimarães CS, Cavellani CL, Castro EC, Miranda Correa RR
Fetal Pediatr Pathol 2012 Aug;31(4):240-7. Epub 2012 Mar 14 doi: 10.3109/15513815.2011.650505. PMID: 22417002
Thalassemia intermedia: revisited.
Taher A, Isma'eel H, Cappellini MD
Blood Cells Mol Dis 2006 Jul-Aug;37(1):12-20. Epub 2006 Jun 5 doi: 10.1016/j.bcmd.2006.04.005. PMID: 16737833
Intra-serous haematopoiesis.
Vaunois B, Breyton M, Seigneurin D, Boutonnat J
In Vivo 2005 Mar-Apr;19(2):407-15. PMID: 15796205

Diagnosis

Adrenal extramedullary haematopoiesis: an unusual incidentaloma.
Agarwal S, Dey M, Yadav P, Lal H
BMJ Case Rep 2021 Jan 11;14(1) doi: 10.1136/bcr-2020-238572. PMID: 33431466Free PMC Article
Intrathoracic extramedullary haematopoiesis.
Arjun P, Thomas M
Postgrad Med J 2020 Jan;96(1131):56. Epub 2019 Sep 11 doi: 10.1136/postgradmedj-2019-137039. PMID: 31511317
Thalasaaemia and extramedullary haematopoiesis.
Kopp CR, Kumar M, Sandal R, Mishra K, Malhotra P
QJM 2019 Jul 1;112(7):543-544. doi: 10.1093/qjmed/hcz008. PMID: 30629265
Extramedullary Hematopoiesis in β-Thalassemia.
Kalchiem-Dekel O, Greenbaum U
Mayo Clin Proc 2015 Nov;90(11):1591-2. doi: 10.1016/j.mayocp.2015.07.031. PMID: 26541258
Extramedullary hemopoiesis.
Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS
Semin Ultrasound CT MR 2014 Jun;35(3):255-62. Epub 2013 Dec 19 doi: 10.1053/j.sult.2013.12.001. PMID: 24929265

Therapy

Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective.
Savani M, Dulery R, Bazarbachi AH, Mohty R, Brissot E, Malard F, Bazarbachi A, Nagler A, Mohty M
Br J Haematol 2021 Nov;195(4):495-506. Epub 2021 Apr 21 doi: 10.1111/bjh.17469. PMID: 33881169
Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
An unusual presentation of primary myelofibrosis.
Tiwari P, Mahajan V, Muhrerkar K
Indian J Tuberc 2018 Jul;65(3):262-265. Epub 2017 Aug 3 doi: 10.1016/j.ijtb.2017.06.014. PMID: 29933872
Perinephric haematopoiesis.
Choi PY
Med J Aust 2008 Feb 18;188(4):250. doi: 10.5694/j.1326-5377.2008.tb01598.x. PMID: 18279138
Left-sided splenorenal fusion with marked extramedullary hematopoiesis and concurrent lithium toxicity. A case report and review of the literature.
Yuan S, Vaughan M, Agoff SN
Arch Pathol Lab Med 2003 Jan;127(1):e1-3. doi: 10.5858/2003-127-e1-LSSFWM. PMID: 12562283

Prognosis

Clonal monocytosis of renal significance.
Natu AA, Gupta I, Leung N, Alexander MP, Patnaik MM
Kidney Int 2024 Dec;106(6):1062-1071. Epub 2024 Sep 18 doi: 10.1016/j.kint.2024.07.036. PMID: 39299498Free PMC Article
Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective.
Savani M, Dulery R, Bazarbachi AH, Mohty R, Brissot E, Malard F, Bazarbachi A, Nagler A, Mohty M
Br J Haematol 2021 Nov;195(4):495-506. Epub 2021 Apr 21 doi: 10.1111/bjh.17469. PMID: 33881169
Nodal extramedullary hematopoiesis and facial bone change in thalassemia.
Daneshbod Y, Kazemi T
Blood 2015 Oct 22;126(17):2070. doi: 10.1182/blood-2015-07-652396. PMID: 26788567
Extramedullary hematopoiesis in pyogenic granuloma.
Waraasawapati S, Koonmee S, Kusama H, Kudo M
Pathol Int 2013 Oct;63(10):492-5. Epub 2013 Oct 18 doi: 10.1111/pin.12096. PMID: 24147429
Pericardial tamponade in chronic myelomonocytic leukemia.
Mani S, Duffy TP
Chest 1994 Sep;106(3):967-70. doi: 10.1378/chest.106.3.967. PMID: 8082394

Clinical prediction guides

Clonal monocytosis of renal significance.
Natu AA, Gupta I, Leung N, Alexander MP, Patnaik MM
Kidney Int 2024 Dec;106(6):1062-1071. Epub 2024 Sep 18 doi: 10.1016/j.kint.2024.07.036. PMID: 39299498Free PMC Article
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Up-regulated expression of CXCL12 in human spleens with extramedullary haematopoiesis.
Miwa Y, Hayashi T, Suzuki S, Abe S, Onishi I, Kirimura S, Kitagawa M, Kurata M
Pathology 2013 Jun;45(4):408-16. doi: 10.1097/PAT.0b013e3283613dbf. PMID: 23619587
Thalassemia intermedia: revisited.
Taher A, Isma'eel H, Cappellini MD
Blood Cells Mol Dis 2006 Jul-Aug;37(1):12-20. Epub 2006 Jun 5 doi: 10.1016/j.bcmd.2006.04.005. PMID: 16737833
Liver dysfunction following splenectomy in idiopathic myelofibrosis: a study of 10 patients.
López-Guillermo A, Cervantes F, Bruguera M, Pereira A, Feliu E, Rozman C
Acta Haematol 1991;85(4):184-8. doi: 10.1159/000204888. PMID: 1677228

Recent systematic reviews

Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review.
A Subahi E, Ata F, Choudry H, Iqbal P, A AlHiyari M, T Soliman A, De Sanctis V, A Yassin M
Ann Med 2022 Dec;54(1):764-774. doi: 10.1080/07853890.2022.2048065. PMID: 35261317Free PMC Article
Comparison of Renal Anastomosing Hemangiomas in End-Stage and Non-End-Stage Kidneys: A Meta-Analysis With a Report of 2 Cases.
Berker NK, Bayram A, Tas S, Bakir B, Caliskan Y, Ozcan F, Kilicaslan I, Ozluk Y
Int J Surg Pathol 2017 Sep;25(6):488-496. Epub 2017 Apr 24 doi: 10.1177/1066896917706025. PMID: 28436289
A systematic review of presacral extramedullary haematopoiesis: a diagnosis to be considered for presacral masses.
Zhou PP, Clark E, Kapadia MR
Colorectal Dis 2016 Nov;18(11):1033-1040. doi: 10.1111/codi.13427. PMID: 27329993
Extramedullary hemopoiesis.
Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS
Semin Ultrasound CT MR 2014 Jun;35(3):255-62. Epub 2013 Dec 19 doi: 10.1053/j.sult.2013.12.001. PMID: 24929265

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