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Liver Synovial Sarcoma

MedGen UID:
474708
•Concept ID:
C3273075
•
Neoplastic Process
Synonym: Hepatic Synovial Sarcoma

Definition

A synovial sarcoma that affects the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Synovial Sarcoma

Professional guidelines

PubMed

Early phase trials in soft-tissue sarcomas: clinical benefit of inclusion in early lines of treatment, molecular screening, and histology-driven trials.
Nassif EF, Blay JY, Massard C, Dufresne A, Brahmi M, Cassier P, Ray-Coquard I, Pautier P, Leary A, Sunyach MP, Bahleda R, Levy A, Le Pechoux C, Honoré C, Mir O, Le Cesne A
ESMO Open 2022 Apr;7(2):100425. Epub 2022 Mar 5 doi: 10.1016/j.esmoop.2022.100425. PMID: 35255445Free PMC Article
The clinical outcome of pazopanib treatment in Japanese patients with relapsed soft tissue sarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study.
Nakamura T, Matsumine A, Kawai A, Araki N, Goto T, Yonemoto T, Sugiura H, Nishida Y, Hiraga H, Honoki K, Yasuda T, Boku S, Sudo A, Ueda T
Cancer 2016 May 1;122(9):1408-16. Epub 2016 Mar 11 doi: 10.1002/cncr.29961. PMID: 26970174Free PMC Article
Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens--a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study.
Van Glabbeke M, van Oosterom AT, Oosterhuis JW, Mouridsen H, Crowther D, Somers R, Verweij J, Santoro A, Buesa J, Tursz T
J Clin Oncol 1999 Jan;17(1):150-7. doi: 10.1200/JCO.1999.17.1.150. PMID: 10458228

Recent clinical studies

Etiology

The impact of margins and re-resection in pediatric synovial sarcoma.
Espinoza AF, Shetty PB, Jacobson JC, Todd H, Harrell K, Trappey AF, Doski J, Castro EC, Montgomery NI, Okcu MF, Venkatramani R, Chung DH, Vasudevan SA
Cancer Med 2024 Sep;13(17):e70207. doi: 10.1002/cam4.70207. PMID: 39279240Free PMC Article
What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case-control from a sarcoma referral centre.
Hasan O, Nasir M, Jessar M, Hashimi M, An Q, Miller BJ
J Surg Oncol 2021 Dec;124(8):1491-1498. Epub 2021 Aug 12 doi: 10.1002/jso.26645. PMID: 34382687
Efficacy and safety of trabectedin for patients with unresectable and relapsed soft-tissue sarcoma in Japan: A Japanese Musculoskeletal Oncology Group study.
Kobayashi H, Iwata S, Wakamatsu T, Hayakawa K, Yonemoto T, Wasa J, Oka H, Ueda T, Tanaka S
Cancer 2020 Mar 15;126(6):1253-1263. Epub 2019 Dec 11 doi: 10.1002/cncr.32661. PMID: 31825533
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Metastatic patterns in soft-tissue sarcomas.
Vezeridis MP, Moore R, Karakousis CP
Arch Surg 1983 Aug;118(8):915-8. doi: 10.1001/archsurg.1983.01390080023007. PMID: 6307217

Diagnosis

The impact of margins and re-resection in pediatric synovial sarcoma.
Espinoza AF, Shetty PB, Jacobson JC, Todd H, Harrell K, Trappey AF, Doski J, Castro EC, Montgomery NI, Okcu MF, Venkatramani R, Chung DH, Vasudevan SA
Cancer Med 2024 Sep;13(17):e70207. doi: 10.1002/cam4.70207. PMID: 39279240Free PMC Article
Biphasic synovial sarcomas of the liver: a case report and literature review.
Liang D, Meng L, Wang S, Yi D, Liu Y
Diagn Pathol 2022 Jun 2;17(1):49. doi: 10.1186/s13000-022-01233-4. PMID: 35655305Free PMC Article
Synovial sarcoma in a premature newborn.
Köse D, Annagür A, Erol C, Uğraş S, Köksal Y
Pediatr Int 2014 Jun;56(3):e17-20. doi: 10.1111/ped.12338. PMID: 24894940
Primary cardiac synovial sarcoma.
Varma T, Adegboyega P
Arch Pathol Lab Med 2012 Apr;136(4):454-8. doi: 10.5858/arpa.2011-0008-RS. PMID: 22458908
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Therapy

Development and Validation of the Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients With Synovial Sarcoma.
Song Z, Cheng L, Lu L, Lu W, Zhou Y, Wang Z
Front Endocrinol (Lausanne) 2021;12:764571. Epub 2022 Mar 4 doi: 10.3389/fendo.2021.764571. PMID: 35308782Free PMC Article
What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case-control from a sarcoma referral centre.
Hasan O, Nasir M, Jessar M, Hashimi M, An Q, Miller BJ
J Surg Oncol 2021 Dec;124(8):1491-1498. Epub 2021 Aug 12 doi: 10.1002/jso.26645. PMID: 34382687
Efficacy and safety of trabectedin for patients with unresectable and relapsed soft-tissue sarcoma in Japan: A Japanese Musculoskeletal Oncology Group study.
Kobayashi H, Iwata S, Wakamatsu T, Hayakawa K, Yonemoto T, Wasa J, Oka H, Ueda T, Tanaka S
Cancer 2020 Mar 15;126(6):1253-1263. Epub 2019 Dec 11 doi: 10.1002/cncr.32661. PMID: 31825533
Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma.
De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A
Drug Des Devel Ther 2015;9:5785-91. Epub 2015 Oct 27 doi: 10.2147/DDDT.S92395. PMID: 26604682Free PMC Article
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Prognosis

Association of SMC4 with prognosis and immune infiltration of sarcoma.
Jiang G, Chen J, Li Y, Zhou J, Wang W, Wu G, Zhang Y
Aging (Albany NY) 2023 Jan 30;15(2):567-582. doi: 10.18632/aging.204503. PMID: 36719264Free PMC Article
Soft tissue sarcoma incidences and clinical characteristics are significantly different in France and Taiwan.
Chen TW, Chiang RC, Le Cesne A, Hsieh YC, Italiano A, Yang YW, Penel N, Lee WC, Bompas E, Valentin T, Anract P, Firmin N, Duffaud F, Cheng AL, Ducimetiere F, Chan KA, Blay JY
Cancer 2022 Sep 15;128(18):3360-3369. Epub 2022 Jul 7 doi: 10.1002/cncr.34372. PMID: 35796499
Primary synovial sarcoma of the prostate metastatic to the liver and lung: a case report.
Zhang Q, Wang H, Ren L, Qi X, Liu F, Zhang D
World J Surg Oncol 2014 Jun 27;12:194. doi: 10.1186/1477-7819-12-194. PMID: 24969223Free PMC Article
Primary cardiac synovial sarcoma.
Varma T, Adegboyega P
Arch Pathol Lab Med 2012 Apr;136(4):454-8. doi: 10.5858/arpa.2011-0008-RS. PMID: 22458908
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Clinical prediction guides

The impact of margins and re-resection in pediatric synovial sarcoma.
Espinoza AF, Shetty PB, Jacobson JC, Todd H, Harrell K, Trappey AF, Doski J, Castro EC, Montgomery NI, Okcu MF, Venkatramani R, Chung DH, Vasudevan SA
Cancer Med 2024 Sep;13(17):e70207. doi: 10.1002/cam4.70207. PMID: 39279240Free PMC Article
Real-world outcomes of pazopanib in metastatic soft tissue sarcoma: a retrospective Turkish oncology group (TOG) study.
Bilici A, Koca S, Karaagac M, Aydin SG, Eraslan E, Kaplan MA, Ocak B, Goksu SS, Paydas S, Akgul F, Derin S, Ergun Y, Yekeduz E, Erol C, Ozyukseler DT, Demiray AG, Karaca M, Guc ZG, Menekse S, Cinkir HY, Gumusay O, Sakin A, Ozkul O, Demir H, Erdem D, Besiroglu M, Unal OU, Acar R, Koral L, Sahin S, Sakalar T, Bahceci A, Ozveren A, Gunaydin UM, Seker MM, Sunar V, Dal P, Artac M, Turhal S
J Cancer Res Clin Oncol 2023 Sep;149(11):8243-8253. Epub 2023 Apr 17 doi: 10.1007/s00432-023-04766-3. PMID: 37067546
Development and Validation of the Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients With Synovial Sarcoma.
Song Z, Cheng L, Lu L, Lu W, Zhou Y, Wang Z
Front Endocrinol (Lausanne) 2021;12:764571. Epub 2022 Mar 4 doi: 10.3389/fendo.2021.764571. PMID: 35308782Free PMC Article
A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients.
Giraudet AL, Cassier PA, Iwao-Fukukawa C, Garin G, Badel JN, Kryza D, Chabaud S, Gilles-Afchain L, Clapisson G, Desuzinges C, Sarrut D, Halty A, Italiano A, Mori M, Tsunoda T, Katagiri T, Nakamura Y, Alberti L, Cropet C, Baconnier S, Berge-Montamat S, Pérol D, Blay JY
BMC Cancer 2018 Jun 8;18(1):646. doi: 10.1186/s12885-018-4544-x. PMID: 29884132Free PMC Article
DR6 as a diagnostic and predictive biomarker in adult sarcoma.
Yang K, Mooney C, Spahlinger G, Schuetze S, Arias-Pulido H, Verschraegen C, Gimotty P, Buckanovich RJ
PLoS One 2012;7(5):e36525. Epub 2012 May 2 doi: 10.1371/journal.pone.0036525. PMID: 22567163Free PMC Article

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