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Childhood Depression

MedGen UID:
473582
•Concept ID:
C2363919
•
Mental or Behavioral Dysfunction

Definition

Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Depression

Professional guidelines

PubMed

Screening for Depression in Pediatric Primary Care.
Forman-Hoffman VL, Viswanathan M
Curr Psychiatry Rep 2018 Jul 23;20(8):62. doi: 10.1007/s11920-018-0926-7. PMID: 30039275
Treatment of anxiety and depression in the preschool period.
Luby JL
J Am Acad Child Adolesc Psychiatry 2013 Apr;52(4):346-58. doi: 10.1016/j.jaac.2013.01.011. PMID: 23582866Free PMC Article
Differential diagnosis of childhood depression: using comorbidity and symptom overlap to generate multiple hypotheses.
de Mesquita PB, Gilliam WS
Child Psychiatry Hum Dev 1994 Spring;24(3):157-72. doi: 10.1007/BF02353193. PMID: 8174393

Recent clinical studies

Etiology

Childhood Trauma and Childhood Mental Disorder in Military and Employed Civilian Men.
Syed Sheriff R, Van Hooff M, Malhi G, Grace B, McFarlane A
J Nerv Ment Dis 2020 Jan;208(1):13-20. doi: 10.1097/NMD.0000000000001072. PMID: 31834189
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Depression in children.
Kapornai K, Vetró A
Curr Opin Psychiatry 2008 Jan;21(1):1-7. doi: 10.1097/YCO.0b013e3282f25b01. PMID: 18281833
Understanding childhood depression.
Malhotra S, Das PP
Indian J Med Res 2007 Feb;125(2):115-28. PMID: 17431280
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707

Diagnosis

Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Understanding childhood depression.
Malhotra S, Das PP
Indian J Med Res 2007 Feb;125(2):115-28. PMID: 17431280
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707
Childhood depression.
Kazdin AE
J Child Psychol Psychiatry 1990 Jan;31(1):121-60. doi: 10.1111/j.1469-7610.1990.tb02276.x. PMID: 2179245
Childhood depression.
Shaw JA
Med Clin North Am 1988 Jul;72(4):831-45. doi: 10.1016/s0025-7125(16)30747-7. PMID: 3287040

Therapy

Development and efficacy of a family-focused treatment for depression in childhood.
Tompson MC, Langer DA, Asarnow JR
J Affect Disord 2020 Nov 1;276:686-695. Epub 2020 Jul 14 doi: 10.1016/j.jad.2020.06.057. PMID: 32871701Free PMC Article
A review of nutrient treatments for paediatric depression.
Lopresti AL
J Affect Disord 2015 Aug 1;181:24-32. Epub 2015 Apr 13 doi: 10.1016/j.jad.2015.04.014. PMID: 25913919
Depression in children.
Kapornai K, Vetró A
Curr Opin Psychiatry 2008 Jan;21(1):1-7. doi: 10.1097/YCO.0b013e3282f25b01. PMID: 18281833
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707
Childhood depression.
Kazdin AE
J Child Psychol Psychiatry 1990 Jan;31(1):121-60. doi: 10.1111/j.1469-7610.1990.tb02276.x. PMID: 2179245

Prognosis

Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Prevention of childhood depression: recent findings and future prospects.
Beardslee WR, Gladstone TR
Biol Psychiatry 2001 Jun 15;49(12):1101-10. doi: 10.1016/s0006-3223(01)01126-x. PMID: 11430852
Childhood depression.
Shaw JA
Med Clin North Am 1988 Jul;72(4):831-45. doi: 10.1016/s0025-7125(16)30747-7. PMID: 3287040
Childhood depression.
Wiener JM, Hendren RL
J Dev Behav Pediatr 1983 Mar;4(1):43-9. doi: 10.1097/00004703-198303000-00009. PMID: 6833504

Clinical prediction guides

Depression in 3/6-year-old children: clinical and psychosocial outcomes in later childhood and adolescence.
Silver J, Olino TM, Carlson GA, Dougherty LR, Bufferd SJ, Klein DN
J Child Psychol Psychiatry 2022 Sep;63(9):984-991. Epub 2021 Dec 2 doi: 10.1111/jcpp.13553. PMID: 34859433
Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Development and efficacy of a family-focused treatment for depression in childhood.
Tompson MC, Langer DA, Asarnow JR
J Affect Disord 2020 Nov 1;276:686-695. Epub 2020 Jul 14 doi: 10.1016/j.jad.2020.06.057. PMID: 32871701Free PMC Article
Early childhood depression, emotion regulation, episodic memory, and hippocampal development.
Barch DM, Harms MP, Tillman R, Hawkey E, Luby JL
J Abnorm Psychol 2019 Jan;128(1):81-95. doi: 10.1037/abn0000392. PMID: 30628810Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article

Recent systematic reviews

Review: What Outcomes Count? A Review of Outcomes Measured for Adolescent Depression Between 2007 and 2017.
Krause KR, Bear HA, Edbrooke-Childs J, Wolpert M
J Am Acad Child Adolesc Psychiatry 2019 Jan;58(1):61-71. Epub 2018 Oct 29 doi: 10.1016/j.jaac.2018.07.893. PMID: 30577940
Exposure to violence in breast cancer patients: systematic review.
Aygin D, Bozdemir H
Breast Cancer 2019 Jan;26(1):29-38. Epub 2018 Aug 22 doi: 10.1007/s12282-018-0900-6. PMID: 30136077
Preventing depression in the offspring of parents with depression: A systematic review and meta-analysis of randomized controlled trials.
Loechner J, Starman K, Galuschka K, Tamm J, Schulte-Körne G, Rubel J, Platt B
Clin Psychol Rev 2018 Mar;60:1-14. Epub 2017 Nov 29 doi: 10.1016/j.cpr.2017.11.009. PMID: 29305152
Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease.
Li LJ, Ikram MK, Wong TY
J Physiol 2016 Apr 15;594(8):2175-203. Epub 2015 Nov 23 doi: 10.1113/JP270947. PMID: 26435039Free PMC Article
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data.
Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E
Lancet 2004 Apr 24;363(9418):1341-5. doi: 10.1016/S0140-6736(04)16043-1. PMID: 15110490

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