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Liver Carcinosarcoma

MedGen UID:
473513
•Concept ID:
C2007076
•
Neoplastic Process
Synonym: Hepatic Carcinosarcoma

Definition

An aggressive carcinoma with a sarcomatous component that arises from the liver. The sarcomatous component is clonally related to the more differentiated, carcinomatous component. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Carcinosarcoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Management of primary liver sarcomas.
Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, Fong Y, Brennan MF, Blumgart LH, Dematteo RP
Cancer 2007 Apr 1;109(7):1391-6. doi: 10.1002/cncr.22530. PMID: 17315167
Results of treatment of primary liver cancer at Kaunas University of Medicine Hospital.
Jievaltas M, Stoskuviene L, Petrenkiene V, Barauskas G, Pundzius J
Medicina (Kaunas) 2004;40(2):127-34. PMID: 15007271

Recent clinical studies

Etiology

Efficacy and safety of nivolumab plus apatinib in advanced liver carcinosarcoma: a case report.
Zhao L, Yang Y, Gao Q
Immunotherapy 2019 Jun;11(8):651-656. doi: 10.2217/imt-2018-0214. PMID: 31088237

Diagnosis

Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case.
Xiang S, Chen YF, Guan Y, Chen XP
World J Gastroenterol 2015 Jun 21;21(23):7335-42. doi: 10.3748/wjg.v21.i23.7335. PMID: 26109824Free PMC Article
MR imaging of carcinosarcoma of the liver using Gd-EOB-DTPA.
Yasutake T, Kiryu S, Akai H, Watadani T, Akahane M, Tomizawa N, Gonoi W, Ikemura M, Takahashi M, Matsuoka Y, Ohtomo K
Magn Reson Med Sci 2014;13(2):117-21. Epub 2014 Apr 28 doi: 10.2463/mrms.2013-0011. PMID: 24769633
A case of primary liver carcinosarcoma: CT findings.
Shu RY, Ye M, Yu WY
Chin J Cancer 2010 Mar;29(3):346-8. doi: 10.5732/cjc.009.10473. PMID: 20193123
Carcinosarcoma of the liver: a case report and review of the literature.
She R, Szakacs J
Arch Pathol Lab Med 2005 Jun;129(6):790-3. doi: 10.5858/2005-129-790-COTLAC. PMID: 15913431
Carcinosarcoma of the liver with mesenchymal differentiation: a case report.
Leger-Ravet MB, Borgonovo G, Amato A, Lemaigre G, Franco D
Hepatogastroenterology 1996 Jan-Feb;43(7):255-9. PMID: 8682474

Therapy

Efficacy and safety of nivolumab plus apatinib in advanced liver carcinosarcoma: a case report.
Zhao L, Yang Y, Gao Q
Immunotherapy 2019 Jun;11(8):651-656. doi: 10.2217/imt-2018-0214. PMID: 31088237
Carcinosarcoma of the liver: a case report and review of the literature.
She R, Szakacs J
Arch Pathol Lab Med 2005 Jun;129(6):790-3. doi: 10.5858/2005-129-790-COTLAC. PMID: 15913431

Prognosis

Efficacy and safety of nivolumab plus apatinib in advanced liver carcinosarcoma: a case report.
Zhao L, Yang Y, Gao Q
Immunotherapy 2019 Jun;11(8):651-656. doi: 10.2217/imt-2018-0214. PMID: 31088237
Carcinosarcoma of the liver producing granulocyte-colony stimulating factor.
Aita K, Seki K
Pathol Int 2006 Jul;56(7):413-9. doi: 10.1111/j.1440-1827.2006.01979.x. PMID: 16792552
Carcinosarcoma of the liver: a case report and review of the literature.
She R, Szakacs J
Arch Pathol Lab Med 2005 Jun;129(6):790-3. doi: 10.5858/2005-129-790-COTLAC. PMID: 15913431

Clinical prediction guides

Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case.
Xiang S, Chen YF, Guan Y, Chen XP
World J Gastroenterol 2015 Jun 21;21(23):7335-42. doi: 10.3748/wjg.v21.i23.7335. PMID: 26109824Free PMC Article
Carcinosarcoma of the liver producing granulocyte-colony stimulating factor.
Aita K, Seki K
Pathol Int 2006 Jul;56(7):413-9. doi: 10.1111/j.1440-1827.2006.01979.x. PMID: 16792552

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