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Paraneoplastic Syndromes, Ocular

MedGen UID:
465285
•Concept ID:
C3178817
•
Disease or Syndrome
Synonyms: Disease, Ocular Paraneoplastic; Diseases, Ocular Paraneoplastic; Ocular Paraneoplastic Disease; Ocular Paraneoplastic Diseases; Ocular Paraneoplastic Syndrome; Ocular Paraneoplastic Syndromes; Paraneoplastic Disease, Ocular; Paraneoplastic Diseases, Ocular; Paraneoplastic Syndrome, Ocular; Syndrome, Ocular Paraneoplastic; Syndromes, Ocular Paraneoplastic

Definition

Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Syndromes, Ocular

Professional guidelines

PubMed

Therapeutic approaches and targets for treatment of autoimmune bullous diseases.
Bardazzi F, Loi C, Chessa Marco A, Di Altobrando A, Filippi F, Lacava R, Viviani F, Balestri R, Leuzzi M, Sacchelli L
Dermatol Ther 2021 Sep;34(5):e15032. Epub 2021 Jul 14 doi: 10.1111/dth.15032. PMID: 34145701
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management.
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019
The radiographic diagnosis and treatment of paraneoplastic central nervous system disease.
Glantz MJ, Biran H, Myers ME, Gockerman JP, Friedberg MH
Cancer 1994 Jan 1;73(1):168-75. doi: 10.1002/1097-0142(19940101)73:1<168::aid-cncr2820730129>3.0.co;2-z. PMID: 8275420

Recent clinical studies

Etiology

Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Neoplastic lymphomatous submaculopathy.
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
Paraneoplastic syndromes in ophthalmology.
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239
Melanoma-Associated Retinopathy 28 Years After Diagnosis.
Tian JJ, Coupland S, Karanjia R, Sadun AA
JAMA Ophthalmol 2017 Nov 1;135(11):1276-1277. doi: 10.1001/jamaophthalmol.2017.3500. PMID: 28975251Free PMC Article
Ophthalmology manifestations of pediatric cancer treatment.
Salvin JH, Hendricks D
Curr Opin Ophthalmol 2012 Sep;23(5):394-9. doi: 10.1097/ICU.0b013e328356230f. PMID: 22729184

Diagnosis

Paraneoplastic vision loss.
Tajfirouz D, Chen JJ
Handb Clin Neurol 2024;200:203-210. doi: 10.1016/B978-0-12-823912-4.00003-7. PMID: 38494278
Diagnostic and Therapeutic Challenges.
Gupta RR, Jiang S, Seamone ME, Iaboni DSM, Choudhry N, Levin MH
Retina 2022 Mar 1;42(3):584-587. doi: 10.1097/IAE.0000000000003204. PMID: 33965995
Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Autoimmune retinopathy.
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Therapy

Novel LRRFIP2-RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications.
LeBlanc RE, Lefferts JA, Baker ML, Linos KD
J Cutan Pathol 2020 Dec;47(12):1181-1186. Epub 2020 Sep 7 doi: 10.1111/cup.13817. PMID: 32700768
Neoplastic lymphomatous submaculopathy.
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
Vision Loss With Postmenopausal Bleeding.
Micieli JA, Lam K, Margolin EA
JAMA Ophthalmol 2016 Jul 1;134(7):831-2. doi: 10.1001/jamaophthalmol.2015.5005. PMID: 27149366
Ophthalmology manifestations of pediatric cancer treatment.
Salvin JH, Hendricks D
Curr Opin Ophthalmol 2012 Sep;23(5):394-9. doi: 10.1097/ICU.0b013e328356230f. PMID: 22729184
The potential role of plasma exchange as a treatment for bilateral diffuse uveal melanocytic proliferation: a report of two cases.
Jaben EA, Pulido JS, Pittock S, Markovic S, Winters JL
J Clin Apher 2011 Dec;26(6):356-61. Epub 2011 Sep 5 doi: 10.1002/jca.20310. PMID: 21898575

Prognosis

Paraneoplastic syndromes in ophthalmology.
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
The Enigma of CRB1 and CRB1 Retinopathies.
Ray TA, Cochran KJ, Kay JN
Adv Exp Med Biol 2019;1185:251-255. doi: 10.1007/978-3-030-27378-1_41. PMID: 31884620
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Autoimmune retinopathy.
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Clinical prediction guides

The Enigma of CRB1 and CRB1 Retinopathies.
Ray TA, Cochran KJ, Kay JN
Adv Exp Med Biol 2019;1185:251-255. doi: 10.1007/978-3-030-27378-1_41. PMID: 31884620
Diffuse Uveal Melanocytic Proliferation With Primary Vitreoretinal Lymphoma.
Leskov I, Lyon AT, Jampol LM
JAMA Ophthalmol 2019 Jul 1;137(7):834-837. doi: 10.1001/jamaophthalmol.2019.0905. PMID: 31046111Free PMC Article
Diagnosis difficulties in a patient with progressive loss of vision - a case report.
Cristescu TR
Rom J Ophthalmol 2017 Jan-Mar;61(1):60-64. doi: 10.22336/rjo.2017.11. PMID: 29450373Free PMC Article
Paraneoplastic Optic Neuropathy Associated With Purkinje Cell Antibody-2 in a Patient With Small Cell Lung Cancer.
Micieli JA, Margolin EA
J Neuroophthalmol 2017 Mar;37(1):53-55. doi: 10.1097/WNO.0000000000000458. PMID: 27759576
Latest updates on antiretinal autoantibodies associated with vision loss and breast cancer.
Adamus G
Invest Ophthalmol Vis Sci 2015 Mar 9;56(3):1680-8. doi: 10.1167/iovs.14-15739. PMID: 25754855Free PMC Article

Recent systematic reviews

Treatment of Cancer-Associated Retinopathy: A Systematic Literature Review.
Brossard-Barbosa N, Dezard V, Margolin E
Ophthalmol Retina 2023 Sep;7(9):819-828. Epub 2023 May 7 doi: 10.1016/j.oret.2023.05.002. PMID: 37160190
Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Paraneoplastic syndromes associated with gynecological cancers: A systematic review.
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M
Gynecol Oncol 2017 Sep;146(3):661-671. Epub 2017 Jun 24 doi: 10.1016/j.ygyno.2017.06.025. PMID: 28655412

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