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Gastric Adenoma, Intestinal-Type

MedGen UID:
459974
•Concept ID:
C3146245
•
Neoplastic Process
Synonyms: Gastric Adenomatous Polyp; Gastric Adenomatous Polyp, Intestinal-Type

Definition

A neoplastic polyp that arises from the stomach. It is associated with intestinal-type differentiation. The presence of high grade dysplasia and a size of more than 2 cm are factors that increase the risk of malignant transformation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Adenoma, Intestinal-Type

Professional guidelines

PubMed

Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm.
Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y
Ann Surg Oncol 2014 Jul;21(7):2444-52. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3565-1. PMID: 24562937
Multiple synchronous early gastric cancers: high-risk group and proper management.
Lee IS, Park YS, Kim KC, Kim TH, Kim HS, Choi KD, Lee GH, Yook JH, Oh ST, Kim BS
Surg Oncol 2012 Dec;21(4):269-73. Epub 2012 Sep 1 doi: 10.1016/j.suronc.2012.08.001. PMID: 22944080

Recent clinical studies

Etiology

YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
Loe AKH, Rao-Bhatia A, Wei Z, Kim JE, Guan B, Qin Y, Hong M, Kwak HS, Liu X, Zhang L, Wrana JL, Guo H, Kim TH
Cell Rep 2023 Dec 26;42(12):113497. Epub 2023 Nov 30 doi: 10.1016/j.celrep.2023.113497. PMID: 38041813
The pathology of gastric and duodenal polyps: current concepts.
Kővári B, Kim BH, Lauwers GY
Histopathology 2021 Jan;78(1):106-124. doi: 10.1111/his.14275. PMID: 33382489
MicroRNA Expression Profiles in Gastric Carcinogenesis.
Hwang J, Min BH, Jang J, Kang SY, Bae H, Jang SS, Kim JI, Kim KM
Sci Rep 2018 Sep 26;8(1):14393. doi: 10.1038/s41598-018-32782-8. PMID: 30258124Free PMC Article
Pathology of gastric cancer and its precursor lesions.
Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640
Cyclooxygenase-2 and gastric carcinogenesis.
Saukkonen K, Rintahaka J, Sivula A, Buskens CJ, Van Rees BP, Rio MC, Haglund C, Van Lanschot JJ, Offerhaus GJ, Ristimaki A
APMIS 2003 Oct;111(10):915-25. doi: 10.1034/j.1600-0463.2003.1111001.x. PMID: 14616542

Diagnosis

Gastric Intestinal Metaplasia: Real Culprit or Innocent Bystander as a Precancerous Condition for Gastric Cancer?
Sugano K, Moss SF, Kuipers EJ
Gastroenterology 2023 Dec;165(6):1352-1366.e1. Epub 2023 Aug 29 doi: 10.1053/j.gastro.2023.08.028. PMID: 37652306
Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up.
Okamoto Y, Kanzaki H, Tanaka T, Sakae H, Abe M, Iwamuro M, Kawano S, Kawahara Y, Okada H
Digestion 2021;102(6):878-886. Epub 2021 Apr 9 doi: 10.1159/000515213. PMID: 33839721
Neoplastic Lesions of Gastric Adenocarcinoma and Proximal Polyposis Syndrome (GAPPS) Are Gastric Phenotype.
de Boer WB, Ee H, Kumarasinghe MP
Am J Surg Pathol 2018 Jan;42(1):1-8. doi: 10.1097/PAS.0000000000000924. PMID: 29112017
Multiple synchronous early gastric cancers: high-risk group and proper management.
Lee IS, Park YS, Kim KC, Kim TH, Kim HS, Choi KD, Lee GH, Yook JH, Oh ST, Kim BS
Surg Oncol 2012 Dec;21(4):269-73. Epub 2012 Sep 1 doi: 10.1016/j.suronc.2012.08.001. PMID: 22944080
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035

Therapy

Clinicopathological characteristics of patients with mucinous adenocarcinoma of the uterine cervix: A retrospective study of 21 cases.
Bonin L, Devouassoux-Shisheboran M, Golfier F
J Gynecol Obstet Hum Reprod 2019 May;48(5):319-327. Epub 2019 Feb 23 doi: 10.1016/j.jogoh.2019.02.002. PMID: 30807852
Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis.
Jang BG, Lee BL, Kim WH
PLoS One 2013;8(12):e82390. Epub 2013 Dec 10 doi: 10.1371/journal.pone.0082390. PMID: 24340024Free PMC Article
2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer.
Penno MA, Klingler-Hoffmann M, Brazzatti JA, Boussioutas A, Putoczki T, Ernst M, Hoffmann P
J Proteomics 2012 Dec 21;77:40-58. Epub 2012 Jul 10 doi: 10.1016/j.jprot.2012.07.002. PMID: 22789672
Cyclooxygenase-2 and gastric carcinogenesis.
Saukkonen K, Rintahaka J, Sivula A, Buskens CJ, Van Rees BP, Rio MC, Haglund C, Van Lanschot JJ, Offerhaus GJ, Ristimaki A
APMIS 2003 Oct;111(10):915-25. doi: 10.1034/j.1600-0463.2003.1111001.x. PMID: 14616542
Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma.
Saito K, Arai K, Mori M, Kobayashi R, Ohki I
Gastrointest Endosc 2000 Jul;52(1):27-32. doi: 10.1067/mge.2000.106112. PMID: 10882958

Prognosis

YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
Loe AKH, Rao-Bhatia A, Wei Z, Kim JE, Guan B, Qin Y, Hong M, Kwak HS, Liu X, Zhang L, Wrana JL, Guo H, Kim TH
Cell Rep 2023 Dec 26;42(12):113497. Epub 2023 Nov 30 doi: 10.1016/j.celrep.2023.113497. PMID: 38041813
Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up.
Okamoto Y, Kanzaki H, Tanaka T, Sakae H, Abe M, Iwamuro M, Kawano S, Kawahara Y, Okada H
Digestion 2021;102(6):878-886. Epub 2021 Apr 9 doi: 10.1159/000515213. PMID: 33839721
Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma.
Na HK, Cho CJ, Bae SE, Lee JH, Park YS, Ahn JY, Kim DH, Choi KD, Song HJ, Lee GH, Jang SJ, Jung HY
PLoS One 2017;12(1):e0169456. Epub 2017 Jan 10 doi: 10.1371/journal.pone.0169456. PMID: 28072871Free PMC Article
Pathology and molecular biology of gastric cancer.
Vauhkonen M, Vauhkonen H, Sipponen P
Best Pract Res Clin Gastroenterol 2006;20(4):651-74. doi: 10.1016/j.bpg.2006.03.016. PMID: 16997151
Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors.
Streit M, Schmidt R, Hilgenfeld RU, Thiel E, Kreuser ED
J Mol Med (Berl) 1996 May;74(5):253-68. doi: 10.1007/BF00196578. PMID: 8773262

Clinical prediction guides

CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors.
Jang B, Lee SH, Dovirak I, Kim H, Srivastava S, Teh M, Yeoh KG, So JB, Tsao SKK, Khor CJ, Ang TL, Goldenring JR
Gastric Cancer 2024 Mar;27(2):263-274. Epub 2024 Jan 14 doi: 10.1007/s10120-023-01458-2. PMID: 38221567Free PMC Article
APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum.
Ishizu K, Hashimoto T, Naka T, Yatabe Y, Kojima M, Kuwata T, Nonaka S, Oda I, Esaki M, Kudo M, Gotohda N, Yoshida T, Yoshikawa T, Sekine S
J Gastroenterol 2021 Nov;56(11):988-998. Epub 2021 Sep 12 doi: 10.1007/s00535-021-01823-x. PMID: 34514550
Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.
Vanoli A, Grillo F, Furlan D, Arpa G, Grami O, Guerini C, Riboni R, Mastracci L, Di Sabatino A
Int J Mol Sci 2021 Apr 22;22(9) doi: 10.3390/ijms22094388. PMID: 33922305Free PMC Article
Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up.
Okamoto Y, Kanzaki H, Tanaka T, Sakae H, Abe M, Iwamuro M, Kawano S, Kawahara Y, Okada H
Digestion 2021;102(6):878-886. Epub 2021 Apr 9 doi: 10.1159/000515213. PMID: 33839721
Carcinogenesis of intestinal-type gastric cancer and colorectal cancer is commonly accompanied by expression of brain (fetal)-type glycogen phosphorylase.
Shimada S, Tashima S, Yamaguchi K, Matsuzaki H, Ogawa M
J Exp Clin Cancer Res 1999 Mar;18(1):111-8. PMID: 10374690

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