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Non-Functioning Pancreatic Neuroendocrine Tumor G1

MedGen UID:
459468
•Concept ID:
C2987242
•
Neoplastic Process
Synonyms: Non-Functional Pancreatic Neuroendocrine Tumor G1; Nonfunctional Pancreatic Neuroendocrine Tumor G1; Nonfunctioning Pancreatic Neuroendocrine Tumor G1

Definition

A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Functioning Pancreatic Neuroendocrine Tumor G1

Professional guidelines

PubMed

European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours.
Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MF, Vullierme MP, Pavel M
J Neuroendocrinol 2024 Sep;36(9):e13423. Epub 2024 Jul 8 doi: 10.1111/jne.13423. PMID: 38977327
Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management.
Panzuto F, Massironi S, Partelli S, Campana D, Rinzivillo M, Invernizzi P, Andreasi V, Lamberti G, Falconi M
Surg Oncol 2020 Dec;35:141-148. Epub 2020 Aug 20 doi: 10.1016/j.suronc.2020.08.015. PMID: 32877883

Recent clinical studies

Etiology

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300
Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.
Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD
Cell 2020 May 14;181(4):832-847.e18. Epub 2020 Apr 17 doi: 10.1016/j.cell.2020.03.062. PMID: 32304665Free PMC Article
Determinants of surgical resection for pancreatic neuroendocrine tumors.
Doi R
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):610-7. Epub 2015 Mar 13 doi: 10.1002/jhbp.224. PMID: 25773163

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours.
Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MF, Vullierme MP, Pavel M
J Neuroendocrinol 2024 Sep;36(9):e13423. Epub 2024 Jul 8 doi: 10.1111/jne.13423. PMID: 38977327
Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300

Therapy

Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Somatostatin analogs in patients with Zollinger Ellison syndrome (ZES): an observational study.
Massironi S, Cavalcoli F, Elvevi A, Quatrini M, Invernizzi P
Endocrine 2022 Mar;75(3):942-948. Epub 2021 Oct 29 doi: 10.1007/s12020-021-02915-7. PMID: 34716542
Solid non-functioning endocrine tumors of the pancreas: correlating computed tomography and pathology.
Zamboni GA, Ambrosetti MC, Zivelonghi C, Lombardo F, Butturini G, Cingarlini S, Capelli P, Pozzi Mucelli R
HPB (Oxford) 2017 Nov;19(11):986-991. Epub 2017 Aug 4 doi: 10.1016/j.hpb.2017.06.013. PMID: 28784262
Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study.
Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
BMC Endocr Disord 2017 Jul 13;17(1):39. doi: 10.1186/s12902-017-0190-6. PMID: 28705205Free PMC Article
Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Prognosis

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300
Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management.
Panzuto F, Massironi S, Partelli S, Campana D, Rinzivillo M, Invernizzi P, Andreasi V, Lamberti G, Falconi M
Surg Oncol 2020 Dec;35:141-148. Epub 2020 Aug 20 doi: 10.1016/j.suronc.2020.08.015. PMID: 32877883

Clinical prediction guides

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300
Recurrence of Pancreatic Neuroendocrine Tumors and Survival Predicted by Ki67.
Genç CG, Falconi M, Partelli S, Muffatti F, van Eeden S, Doglioni C, Klümpen HJ, van Eijck CHJ, Nieveen van Dijkum EJM
Ann Surg Oncol 2018 Aug;25(8):2467-2474. Epub 2018 May 22 doi: 10.1245/s10434-018-6518-2. PMID: 29789972Free PMC Article

Recent systematic reviews

Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis.
Andreasi V, Ricci C, Partelli S, Guarneri G, Ingaldi C, Muffatti F, Crippa S, Casadei R, Falconi M
J Endocrinol Invest 2022 Apr;45(4):705-718. Epub 2021 Nov 13 doi: 10.1007/s40618-021-01705-2. PMID: 34773595

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