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Meningeal Leukemia

MedGen UID:
452807
•Concept ID:
C0948840
•
Neoplastic Process
Synonyms: Leukemic Leptomeningitis; Leukemic leptomeningitis; Leukemic Meningitis; Leukemic meningitis; Meningeal leukemia
SNOMED CT: Meningeal leukemia (722795004); Leukemic leptomeningitis (722795004); Leukemic meningitis (722795004)

Definition

Infiltration of the meninges by an acute or chronic leukemia. [from NCI]

Professional guidelines

PubMed

Treatment of meningeal leukemia.
Simone JV
J Clin Oncol 1984 May;2(5):357-8. doi: 10.1200/JCO.1984.2.5.357. PMID: 6726292
Treatment of meningeal leukemia with pyrimethamine.
Geils GF, Scott CW Jr, Baugh CM, Butterworth
Blood 1971 Aug;38(2):131-7. PMID: 5283025
Clinical investigations in the treatment of meningeal leukemia: radiation therapy regimens vs. conventional intrathecal methotrexate.
Sullivan MP, Vietti TJ, Fernbach DJ, Griffith KM, Haddy TB, Watkins WL
Blood 1969 Sep;34(3):301-19. PMID: 5820049

Recent clinical studies

Etiology

Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264
Radiotherapy vs intrathecal chemotherapy for CNS prophylaxis in childhood ALL.
Steinherz PG
Oncology (Williston Park) 1989 Sep;3(9):47-53; discussion 58-60. PMID: 2701698
Elevated myelin basic protein levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia.
Mahoney DH Jr, Fernbach DJ, Glaze DG, Cohen SR
J Clin Oncol 1984 Jan;2(1):58-61. doi: 10.1200/JCO.1984.2.1.58. PMID: 6199479
Histopathology of CNS leukemia and complications of therapy.
Price RA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):21-30. PMID: 396790
MENINGEAL LEUKEMIA; A FOLLOW-UP STUDY.
NIES BA, THOMAS LB, FREIREICH EJ
Cancer 1965 May;18:546-53. doi: 10.1002/1097-0142(196505)18:5<546::aid-cncr2820180503>3.0.co;2-e. PMID: 14278887

Diagnosis

Pseudo subarachnoid hemorrhage in meningeal leukemia.
Hsieh SW, Khor GT, Chen CN, Huang P
J Emerg Med 2012 May;42(5):e109-11. Epub 2010 May 10 doi: 10.1016/j.jemermed.2010.04.006. PMID: 20452163
Immunocytochemical identification of meningeal leukemia and lymphoma: poly-L-lysine-coated slides permit multimarker analysis even with minute cerebrospinal fluid cell specimens.
Kranz BR, Thiel E, Thierfelder S
Blood 1989 May 15;73(7):1942-50. PMID: 2713509
Cytosine arabinoside cerebrospinal fluid kinetics.
Zimm S, Collins JM, Miser J, Chatterji D, Poplack DG
Clin Pharmacol Ther 1984 Jun;35(6):826-30. doi: 10.1038/clpt.1984.120. PMID: 6587957
Diagnosis of meningeal leukemia in acute childhood lymphocytic leukemia with periodic acid-schiff reaction of cytocentrifuged liquor.
Feldges AJ
Acta Haematol 1973;49(3):154-8. doi: 10.1159/000208404. PMID: 4124478
Meningeal leukemia: challenge in diagnosis and treatment.
Santago-Borrero PJ, Maldonado N, Cáceres-Costas M, Grillo-López AJ
Bol Asoc Med P R 1971 May;63(5):113-9. PMID: 5284832

Therapy

Cytosine arabinoside cerebrospinal fluid kinetics.
Zimm S, Collins JM, Miser J, Chatterji D, Poplack DG
Clin Pharmacol Ther 1984 Jun;35(6):826-30. doi: 10.1038/clpt.1984.120. PMID: 6587957
History of intrathecal prophylaxis and therapy of meningeal leukemia.
Burchenal JH
Cancer Drug Deliv 1983;1(1):87-92. doi: 10.1089/cdd.1983.1.87. PMID: 6549559
Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia.
Bleyer WA, Drake JC, Chabner BA
N Engl J Med 1973 Oct 11;289(15):770-3. doi: 10.1056/NEJM197310112891503. PMID: 4517004
Cerebrospinal axis radiation therapy for meningeal leukemia with tumor dose levels in the range of 2,000 rads.
Castro JR, Sullivan MP
Radiology 1972 Sep;104(3):643-8. doi: 10.1148/104.3.643. PMID: 5051480
Treatment of meningeal leukemia with pyrimethamine.
Geils GF, Scott CW Jr, Baugh CM, Butterworth
Blood 1971 Aug;38(2):131-7. PMID: 5283025

Prognosis

Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264
Radiotherapy vs intrathecal chemotherapy for CNS prophylaxis in childhood ALL.
Steinherz PG
Oncology (Williston Park) 1989 Sep;3(9):47-53; discussion 58-60. PMID: 2701698
Meningeal leukemia after blastic transformation of chronic myeloid leukemia.
Pai VR, Shetty PA
Indian J Cancer 1984 Jan-Feb;20(6):283-5. PMID: 6590464
"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms.
Bleyer WA, Poplack DG, Simon RM
Blood 1978 May;51(5):835-42. PMID: 638249
MENINGEAL LEUKEMIA; A FOLLOW-UP STUDY.
NIES BA, THOMAS LB, FREIREICH EJ
Cancer 1965 May;18:546-53. doi: 10.1002/1097-0142(196505)18:5<546::aid-cncr2820180503>3.0.co;2-e. PMID: 14278887

Clinical prediction guides

Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
Byrd JC, Edenfield WJ, Shields DJ, Dawson NA
J Clin Oncol 1995 Jul;13(7):1800-16. doi: 10.1200/JCO.1995.13.7.1800. PMID: 7602369
Elevated myelin basic protein levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia.
Mahoney DH Jr, Fernbach DJ, Glaze DG, Cohen SR
J Clin Oncol 1984 Jan;2(1):58-61. doi: 10.1200/JCO.1984.2.1.58. PMID: 6199479
Histopathology of CNS leukemia and complications of therapy.
Price RA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):21-30. PMID: 396790
"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms.
Bleyer WA, Poplack DG, Simon RM
Blood 1978 May;51(5):835-42. PMID: 638249
Leukemic ophthalmopathy in children.
Ridgway EW, Jaffe N, Walton DS
Cancer 1976 Oct;38(4):1744-9. doi: 10.1002/1097-0142(197610)38:4<1744::aid-cncr2820380449>3.0.co;2-3. PMID: 1068743

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