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Steroid-induced myopathy

MedGen UID:
452365
•Concept ID:
C0270994
•
Disease or Syndrome
Synonyms: Steroid Myopathy; Steroid myopathy
SNOMED CT: Steroid-induced myopathy (26715006); Steroid myopathy (26715006)

Definition

A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid-induced myopathy

Professional guidelines

PubMed

An efficacy analysis of whole-body magnetic resonance imaging in the diagnosis and follow-up of polymyositis and dermatomyositis.
Huang ZG, Gao BX, Chen H, Yang MX, Chen XL, Yan R, Lu X, Shi KN, Chan Q, Wang GC
PLoS One 2017;12(7):e0181069. Epub 2017 Jul 17 doi: 10.1371/journal.pone.0181069. PMID: 28715432Free PMC Article
Treatment of dermatomyositis with methotrexate.
Zieglschmid-Adams ME, Pandya AG, Cohen SB, Sontheimer RD
J Am Acad Dermatol 1995 May;32(5 Pt 1):754-7. doi: 10.1016/0190-9622(95)91455-2. PMID: 7722021

Recent clinical studies

Etiology

Neurologic Complications in Patients With Lymphoreticular Malignancy: A Descriptive Cohort Study.
Baloda R, Sharma S, Anand R, Mandal P, Parakh N, Katti B, Singh V, Chandra J
J Pediatr Hematol Oncol 2023 Oct 1;45(7):e885-e891. Epub 2023 Jul 24 doi: 10.1097/MPH.0000000000002722. PMID: 37526372
Acute myopathy following intra-muscular injection of compound betamethasone: A case report.
Sun LY, Chu XL
Medicine (Baltimore) 2017 Aug;96(34):e7474. doi: 10.1097/MD.0000000000007474. PMID: 28834869Free PMC Article
Rehabilitation in Chronic Graft-Versus-Host Disease.
Smith SR, Asher A
Phys Med Rehabil Clin N Am 2017 Feb;28(1):143-151. doi: 10.1016/j.pmr.2016.08.009. PMID: 27912993
Steroid-sparing effect of corticorelin acetate in peritumoral cerebral edema is associated with improvement in steroid-induced myopathy.
Recht L, Mechtler LL, Wong ET, O'Connor PC, Rodda BE
J Clin Oncol 2013 Mar 20;31(9):1182-7. Epub 2013 Feb 4 doi: 10.1200/JCO.2012.43.9455. PMID: 23382470
Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease.
Amaya-Villar R, Garnacho-Montero J, García-Garmendía JL, Madrazo-Osuna J, Garnacho-Montero MC, Luque R, Ortiz-Leyba C
Intensive Care Med 2005 Jan;31(1):157-61. Epub 2004 Dec 4 doi: 10.1007/s00134-004-2509-9. PMID: 15580474

Diagnosis

Neurologic Complications in Patients With Lymphoreticular Malignancy: A Descriptive Cohort Study.
Baloda R, Sharma S, Anand R, Mandal P, Parakh N, Katti B, Singh V, Chandra J
J Pediatr Hematol Oncol 2023 Oct 1;45(7):e885-e891. Epub 2023 Jul 24 doi: 10.1097/MPH.0000000000002722. PMID: 37526372
Diagnostic evaluation in steroid-induced myopathy: case report suggesting clinical utility of quantitative muscle ultrasonography.
Minetto MA, Caresio C, D'Angelo V, Lanfranco F, Ghizzoni L, Roatta S, Arvat E, Kesari S
Endocr Res 2018 Nov;43(4):235-245. Epub 2018 Apr 12 doi: 10.1080/07435800.2018.1461904. PMID: 29648902
Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease.
Amaya-Villar R, Garnacho-Montero J, García-Garmendía JL, Madrazo-Osuna J, Garnacho-Montero MC, Luque R, Ortiz-Leyba C
Intensive Care Med 2005 Jan;31(1):157-61. Epub 2004 Dec 4 doi: 10.1007/s00134-004-2509-9. PMID: 15580474
Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
Vallet B, Fourrier F, Hurtevent JF, Parent M, Chopin C
Intensive Care Med 1992;18(7):424-6. doi: 10.1007/BF01694346. PMID: 1469182
Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
Dekhuijzen PN, Decramer M
Eur Respir J 1992 Sep;5(8):997-1003. PMID: 1426209

Therapy

Rehabilitation in Chronic Graft-Versus-Host Disease.
Smith SR, Asher A
Phys Med Rehabil Clin N Am 2017 Feb;28(1):143-151. doi: 10.1016/j.pmr.2016.08.009. PMID: 27912993
Drug-induced myopathies. An overview of the possible mechanisms.
Owczarek J, Jasińska M, Orszulak-Michalak D
Pharmacol Rep 2005 Jan-Feb;57(1):23-34. PMID: 15849374
Steroid-induced myopathy in the ICU.
Polsonetti BW, Joy SD, Laos LF
Ann Pharmacother 2002 Nov;36(11):1741-4. doi: 10.1345/aph.1C095. PMID: 12398571
Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
Vallet B, Fourrier F, Hurtevent JF, Parent M, Chopin C
Intensive Care Med 1992;18(7):424-6. doi: 10.1007/BF01694346. PMID: 1469182
Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
Dekhuijzen PN, Decramer M
Eur Respir J 1992 Sep;5(8):997-1003. PMID: 1426209

Prognosis

A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
Seo JH, Yu HG, Chung H
Korean J Ophthalmol 2009 Jun;23(2):112-3. Epub 2009 Jun 9 doi: 10.3341/kjo.2009.23.2.112. PMID: 19568361Free PMC Article
Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease.
Amaya-Villar R, Garnacho-Montero J, García-Garmendía JL, Madrazo-Osuna J, Garnacho-Montero MC, Luque R, Ortiz-Leyba C
Intensive Care Med 2005 Jan;31(1):157-61. Epub 2004 Dec 4 doi: 10.1007/s00134-004-2509-9. PMID: 15580474
Steroid-induced myopathy in the ICU.
Polsonetti BW, Joy SD, Laos LF
Ann Pharmacother 2002 Nov;36(11):1741-4. doi: 10.1345/aph.1C095. PMID: 12398571
Corticosteroid-induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma.
Decramer M, Stas KJ
Am Rev Respir Dis 1992 Sep;146(3):800-2. doi: 10.1164/ajrccm/146.3.800. PMID: 1519868
Psoriatic arthritis and myopathy.
Thomson GT, Johnston JL, Baragar FD, Toole JW
J Rheumatol 1990 Mar;17(3):395-8. PMID: 2110253

Clinical prediction guides

Neurologic Complications in Patients With Lymphoreticular Malignancy: A Descriptive Cohort Study.
Baloda R, Sharma S, Anand R, Mandal P, Parakh N, Katti B, Singh V, Chandra J
J Pediatr Hematol Oncol 2023 Oct 1;45(7):e885-e891. Epub 2023 Jul 24 doi: 10.1097/MPH.0000000000002722. PMID: 37526372
Steroid-sparing effect of corticorelin acetate in peritumoral cerebral edema is associated with improvement in steroid-induced myopathy.
Recht L, Mechtler LL, Wong ET, O'Connor PC, Rodda BE
J Clin Oncol 2013 Mar 20;31(9):1182-7. Epub 2013 Feb 4 doi: 10.1200/JCO.2012.43.9455. PMID: 23382470
Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease.
Amaya-Villar R, Garnacho-Montero J, García-Garmendía JL, Madrazo-Osuna J, Garnacho-Montero MC, Luque R, Ortiz-Leyba C
Intensive Care Med 2005 Jan;31(1):157-61. Epub 2004 Dec 4 doi: 10.1007/s00134-004-2509-9. PMID: 15580474
Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
Vallet B, Fourrier F, Hurtevent JF, Parent M, Chopin C
Intensive Care Med 1992;18(7):424-6. doi: 10.1007/BF01694346. PMID: 1469182
Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
Dekhuijzen PN, Decramer M
Eur Respir J 1992 Sep;5(8):997-1003. PMID: 1426209

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