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Recurrent painful ophthalmoplegic neuropathy

MedGen UID:
452212
•Concept ID:
C0221058
•
Disease or Syndrome
Synonyms: Migraine Syndrome, Ophthalmoplegic; Migraine Syndromes, Ophthalmoplegic; Migraine, Ophthalmoplegic; Migraines, Ophthalmoplegic; Ophthalmoplegic Migraine; Ophthalmoplegic Migraine Syndrome; Ophthalmoplegic Migraine Syndromes; Ophthalmoplegic Migraines; Syndrome, Ophthalmoplegic Migraine; Syndromes, Ophthalmoplegic Migraine
SNOMED CT: Recurrent painful ophthalmoplegic neuropathy (49605003); Ophthalmoplegic cranial neuropathy (49605003); Recurrent ophthalmoplegic cranial neuropathy (49605003); Ophthalmoplegic migraine (49605003)

Definition

Childhood-onset of recurrent headaches with an oculomotor cranial nerve palsy. Typically, ABDUCENS NERVE; OCULOMOTOR NERVE; and TROCHLEAR NERVE are involved with DIPLOPIA and BLEPHAROPTOSIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent painful ophthalmoplegic neuropathy

Professional guidelines

PubMed

Treatment options for ophthalmoplegic migraine.
Granado L, Guillen G
J Postgrad Med 2009 Jul-Sep;55(3):231; author reply 231-2. doi: 10.4103/0022-3859.57389. PMID: 19884756
Ophthalmoplegic migraine: diagnostic criteria, incidence of hospitalization and possible etiology.
Hansen SL, Borelli-Møller L, Strange P, Nielsen BM, Olesen J
Acta Neurol Scand 1990 Jan;81(1):54-60. doi: 10.1111/j.1600-0404.1990.tb00931.x. PMID: 2330816

Recent clinical studies

Etiology

Recurrent Painful Ophthalmoplegic Neuropathy and Oculomotor Nerve Schwannoma: A Pediatric Case Report with Long-Term MRI Follow-Up and Literature Review.
Petruzzelli MG, Margari M, Furente F, Costanza MC, Legrottaglie AR, Dicuonzo F, Margari L
Pain Res Manag 2019;2019:5392945. Epub 2019 Sep 25 doi: 10.1155/2019/5392945. PMID: 31662812Free PMC Article
Ophthalmoplegia starting with a headache circumscribed in a line-shaped area: a subtype of ophthalmoplegic migraine?
Wang Y, Wang XH, Tian MM, Xie CJ, Liu Y, Pan QQ, Lu YN
J Headache Pain 2014 Apr 16;15(1):19. doi: 10.1186/1129-2377-15-19. PMID: 24739597Free PMC Article

Diagnosis

Recurrent Painful Ophthalmoplegic Neuropathy: A case report with atypical features and a review of the literature.
Furia A, Liguori R, Donadio V
Cephalalgia 2023 Jan;43(1):3331024221133386. doi: 10.1177/03331024221133386. PMID: 36694449
Recurrent Painful Ophthalmoplegic Neuropathy: Migraine, Neuralgia, or Something Else?
Aleksic DZ, Drakulic SM, Ljubisavljevic S
J Oral Facial Pain Headache 2020 Fall;34(4):374-378. doi: 10.11607/ofph.2656. PMID: 33290443
Recurrent Painful Ophthalmoplegic Neuropathy and Oculomotor Nerve Schwannoma: A Pediatric Case Report with Long-Term MRI Follow-Up and Literature Review.
Petruzzelli MG, Margari M, Furente F, Costanza MC, Legrottaglie AR, Dicuonzo F, Margari L
Pain Res Manag 2019;2019:5392945. Epub 2019 Sep 25 doi: 10.1155/2019/5392945. PMID: 31662812Free PMC Article
Relapsing Painful Ophthalmoplegic Neuropathy: No longer a "Migraine," but Still a Headache.
Smith SV, Schuster NM
Curr Pain Headache Rep 2018 Jun 14;22(7):50. doi: 10.1007/s11916-018-0705-5. PMID: 29904898
From ophthalmoplegic migraine to cranial neuropathy.
Förderreuther S, Ruscheweyh R
Curr Pain Headache Rep 2015 Jun;19(6):21. doi: 10.1007/s11916-015-0492-1. PMID: 26021754

Therapy

Recurrent painful ophthalmoplegic neuropathy: a report of two new pediatric cases.
Günay Ç, Edem P, Hız-Kurul AS, Yaşar E, Yiş U
Turk J Pediatr 2022;64(3):592-598. doi: 10.24953/turkjped.2021.1124. PMID: 35899575
Recurrent Painful Ophthalmoplegic Neuropathy with Unilateral Oculomotor and Trochlear Nerve Palsy in an 8-year-old Girl.
Akhondian J, Ashrafzadeh F, Seilanian Toosi F, Esmaeilzadeh M, Beiraghi Toosi M, Imannezhad S, Saeedi Zand N, Hashemi N
J Binocul Vis Ocul Motil 2022 Oct-Dec;72(4):199-204. Epub 2022 Jul 22 PMID: 35867412
Recurrent Painful Ophthalmoplegic Neuropathy with Residual Mydriasis in an Adult: Should it Be Classified as Ophthalmoplegic Migraine?
Kobayashi Y, Kondo Y, Uchibori K, Tsuyuzaki J
Intern Med 2017 Oct 15;56(20):2769-2772. Epub 2017 Sep 15 doi: 10.2169/internalmedicine.8842-17. PMID: 28924127Free PMC Article

Prognosis

Recurrent Painful Ophthalmoplegic Neuropathy and Oculomotor Nerve Schwannoma: A Pediatric Case Report with Long-Term MRI Follow-Up and Literature Review.
Petruzzelli MG, Margari M, Furente F, Costanza MC, Legrottaglie AR, Dicuonzo F, Margari L
Pain Res Manag 2019;2019:5392945. Epub 2019 Sep 25 doi: 10.1155/2019/5392945. PMID: 31662812Free PMC Article
Relapsing Painful Ophthalmoplegic Neuropathy: No longer a "Migraine," but Still a Headache.
Smith SV, Schuster NM
Curr Pain Headache Rep 2018 Jun 14;22(7):50. doi: 10.1007/s11916-018-0705-5. PMID: 29904898

Clinical prediction guides

Oculomotor nerve tumors masquerading as recurrent painful ophthalmoplegic neuropathy: report of two cases and review of the literature.
Kim R, Kim JH, Kim E, Yang HK, Hwang JM, Kim JS
Cephalalgia 2015 Aug;35(9):825-30. Epub 2014 Nov 3 doi: 10.1177/0333102414558886. PMID: 25366549

Recent systematic reviews

Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article

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