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Autoimmune hemolytic anemia, warm type

MedGen UID:
450541
Concept ID:
C0272118
Disease or Syndrome
Synonyms: AIHA - Warm autoimmune hemolytic anemia; autoimmune hemolytic anemia, warm type; Hemolytic anemia due to warm antibody; wAHA; wAIHA; Warm AIHA; warm AIHA; warm antibody AIHA; warm antibody autoimmune hemolytic anaemia; warm antibody autoimmune hemolytic anemia; warm antibody hemolytic anaemia; Warm antibody hemolytic anemia; warm antibody hemolytic anemia; Warm autoimmune hemolytic anemia; Warm Autoimmune Hemolytic Anemia; Warm type hemolytic anemia; warm-reacting-antibody hemolytic anaemia; warm-reacting-antibody hemolytic anemia
SNOMED CT: AIHA - Warm autoimmune hemolytic anemia (3978000); Warm autoimmune hemolytic anemia (3978000); Warm antibody hemolytic anemia (3978000); Hemolytic anemia due to warm antibody (3978000); Warm type hemolytic anemia (3978000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0019532
Orphanet: ORPHA90033

Definition

Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia (see this term) defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40°C). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutoimmune hemolytic anemia, warm type
Follow this link to review classifications for Autoimmune hemolytic anemia, warm type in Orphanet.

Professional guidelines

PubMed

Fattizzo B, Barcellini W
Transfus Med Rev 2022 Oct;36(4):175-180. Epub 2022 Sep 6 doi: 10.1016/j.tmrv.2022.08.001. PMID: 36182620
Hantaweepant C, Pairattanakorn P, Karaketklang K, Owattanapanich W, Chinthammitr Y
Hematology 2019 Dec;24(1):720-726. doi: 10.1080/16078454.2019.1671060. PMID: 31581907

Recent clinical studies

Etiology

Fatone MC, Cirasino L
Clin Exp Med 2023 Jul;23(3):727-736. Epub 2022 Aug 18 doi: 10.1007/s10238-022-00869-2. PMID: 35980482
Fattizzo B, Barcellini W
Transfus Med Rev 2022 Oct;36(4):175-180. Epub 2022 Sep 6 doi: 10.1016/j.tmrv.2022.08.001. PMID: 36182620
Jäger U, Barcellini W, Broome CM, Gertz MA, Hill A, Hill QA, Jilma B, Kuter DJ, Michel M, Montillo M, Röth A, Zeerleder SS, Berentsen S
Blood Rev 2020 May;41:100648. Epub 2019 Dec 5 doi: 10.1016/j.blre.2019.100648. PMID: 31839434
Michel M
Expert Rev Hematol 2011 Dec;4(6):607-18. doi: 10.1586/ehm.11.60. PMID: 22077525
Agarwal B
Indian J Pediatr 1998 Sep-Oct;65(5):663-8. doi: 10.1007/BF02731038. PMID: 10773921

Diagnosis

Jäger U, Barcellini W, Broome CM, Gertz MA, Hill A, Hill QA, Jilma B, Kuter DJ, Michel M, Montillo M, Röth A, Zeerleder SS, Berentsen S
Blood Rev 2020 May;41:100648. Epub 2019 Dec 5 doi: 10.1016/j.blre.2019.100648. PMID: 31839434
Hill A, Hill QA
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):382-389. doi: 10.1182/asheducation-2018.1.382. PMID: 30504336Free PMC Article
Kalfa TA
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):690-697. doi: 10.1182/asheducation-2016.1.690. PMID: 27913548Free PMC Article
Gehrs BC, Friedberg RC
Am J Hematol 2002 Apr;69(4):258-71. doi: 10.1002/ajh.10062. PMID: 11921020
Agarwal B
Indian J Pediatr 1998 Sep-Oct;65(5):663-8. doi: 10.1007/BF02731038. PMID: 10773921

Therapy

Cavallaro F, Barcellini W, Fattizzo B
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1227-1237. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2274912. PMID: 37874225
Argüello Marina M, López Rubio M, Castilla García L
Med Clin (Barc) 2023 Jan 5;160(1):30-38. Epub 2022 Nov 2 doi: 10.1016/j.medcli.2022.07.021. PMID: 36334945
Fattizzo B, Barcellini W
Transfus Med Rev 2022 Oct;36(4):175-180. Epub 2022 Sep 6 doi: 10.1016/j.tmrv.2022.08.001. PMID: 36182620
Jäger U, Barcellini W, Broome CM, Gertz MA, Hill A, Hill QA, Jilma B, Kuter DJ, Michel M, Montillo M, Röth A, Zeerleder SS, Berentsen S
Blood Rev 2020 May;41:100648. Epub 2019 Dec 5 doi: 10.1016/j.blre.2019.100648. PMID: 31839434
Hill A, Hill QA
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):382-389. doi: 10.1182/asheducation-2018.1.382. PMID: 30504336Free PMC Article

Prognosis

Fattizzo B, Marchetti M, Michel M, Cantoni S, Frederiksen H, Giordano G, Glenthøj A, González-López TJ, Murakhovskaya I, Napolitano M, Mingot ME, Arguello M, Patriarca A, Raso S, Vianelli N, Barcellini W
Lancet Haematol 2024 Aug;11(8):e617-e628. Epub 2024 Jul 2 doi: 10.1016/S2352-3026(24)00144-3. PMID: 38968944
Fattizzo B, Barcellini W
Expert Rev Clin Immunol 2022 Jul;18(7):731-745. Epub 2022 Jun 14 doi: 10.1080/1744666X.2022.2089115. PMID: 35702053
Jäger U, Barcellini W, Broome CM, Gertz MA, Hill A, Hill QA, Jilma B, Kuter DJ, Michel M, Montillo M, Röth A, Zeerleder SS, Berentsen S
Blood Rev 2020 May;41:100648. Epub 2019 Dec 5 doi: 10.1016/j.blre.2019.100648. PMID: 31839434
Segel GB, Lichtman MA
Blood Cells Mol Dis 2014 Apr;52(4):152-60. Epub 2014 Jan 9 doi: 10.1016/j.bcmd.2013.12.003. PMID: 24411920
Sève P, Philippe P, Dufour JF, Broussolle C, Michel M
Expert Rev Hematol 2008 Dec;1(2):189-204. doi: 10.1586/17474086.1.2.189. PMID: 21082924

Clinical prediction guides

Kar S, Kumar CGD, Kar R, Basavarajegowda A
Indian J Pediatr 2024 Feb;91(2):143-148. Epub 2023 Feb 14 doi: 10.1007/s12098-022-04469-6. PMID: 36787020
Hantaweepant C, Pairattanakorn P, Karaketklang K, Owattanapanich W, Chinthammitr Y
Hematology 2019 Dec;24(1):720-726. doi: 10.1080/16078454.2019.1671060. PMID: 31581907
Berentsen S, Sundic T
Biomed Res Int 2015;2015:363278. Epub 2015 Jan 29 doi: 10.1155/2015/363278. PMID: 25705656Free PMC Article
Jaime-Pérez JC, Rodríguez-Martínez M, Gómez-de-León A, Tarín-Arzaga L, Gómez-Almaguer D
Arch Immunol Ther Exp (Warsz) 2013 Oct;61(5):385-95. Epub 2013 May 21 doi: 10.1007/s00005-013-0232-3. PMID: 23689532
Dussadee K, Taka O, Thedsawad A, Wanachiwanawin W
J Med Assoc Thai 2010 Jan;93 Suppl 1:S165-70. PMID: 20364571

Recent systematic reviews

Jacobs JW, Booth GS
Am J Clin Pathol 2022 Jun 7;157(6):844-851. doi: 10.1093/ajcp/aqab210. PMID: 34919640Free PMC Article

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