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Mallory-Weiss syndrome

MedGen UID:
44265
•Concept ID:
C0024633
•
Disease or Syndrome
Synonyms: Gastroesophageal laceration-hemorrhage; Mallory-Weiss laceration; Mallory-Weiss tear; Mucosal lacerations - gastroesophageal junction
SNOMED CT: Gastro-esophageal laceration-hemorrhage syndrome (35265002); Mallory-Weiss tear (307131005); Mallory-Weiss syndrome (35265002); Gastroesophageal laceration-hemorrhage syndrome (35265002)
 
HPO: HP:0032062
Monarch Initiative: MONDO:0043247

Definition

Vomiting-induced mucosal laceration at the esophago-gastric junction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMallory-Weiss syndrome

Professional guidelines

PubMed

Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Evaluation and management of Non-variceal upper gastrointestinal bleeding.
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Effective endoscopic treatment of Mallory-Weiss syndrome using Glasgow-Blatchford score and Forrest classification.
Lee S, Ahn JY, Jung HY, Jung KW, Lee JH, Kim DH, Choi KD, Song HJ, Lee GH, Kim JH, Kim SO
J Dig Dis 2016 Oct;17(10):676-684. doi: 10.1111/1751-2980.12409. PMID: 27624697

Recent clinical studies

Etiology

Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Overview of Mallory-Weiss syndrome.
Rich K
J Vasc Nurs 2018 Jun;36(2):91-93. doi: 10.1016/j.jvn.2018.04.001. PMID: 29747789
Evaluation and management of Non-variceal upper gastrointestinal bleeding.
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Treatment of actively bleeding Mallory-Weiss syndrome: epinephrine injection or band ligation?
Gawrieh S, Shaker R
Curr Gastroenterol Rep 2005 Jun;7(3):175. PMID: 15913474
A multidisciplinary approach to gastrointestinal bleeding in cancer patients.
Imbesi JJ, Kurtz RC
J Support Oncol 2005 Mar-Apr;3(2):101-10. PMID: 15796441

Diagnosis

Mallory-Weiss Syndrome.
Hu Z, Liu D
N Engl J Med 2024 May 30;390(20):e49. doi: 10.1056/NEJMicm2310882. PMID: 38810187
Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Overview of Mallory-Weiss syndrome.
Rich K
J Vasc Nurs 2018 Jun;36(2):91-93. doi: 10.1016/j.jvn.2018.04.001. PMID: 29747789
Upper gastrointestinal bleeding.
Feinman M, Haut ER
Surg Clin North Am 2014 Feb;94(1):43-53. doi: 10.1016/j.suc.2013.10.004. PMID: 24267496
Mallory-Weiss syndrome.
Carlson DS, Pfadt E
Nursing 2011 Oct;41(10):72. doi: 10.1097/01.NURSE.0000405123.46887.12. PMID: 21918419

Therapy

Mallory-Weiss Syndrome.
Hu Z, Liu D
N Engl J Med 2024 May 30;390(20):e49. doi: 10.1056/NEJMicm2310882. PMID: 38810187
Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Evaluation and management of Non-variceal upper gastrointestinal bleeding.
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Review on hyperemesis gravidarum.
Ismail SK, Kenny L
Best Pract Res Clin Gastroenterol 2007;21(5):755-69. doi: 10.1016/j.bpg.2007.05.008. PMID: 17889806
Endoclips for GI endoscopy.
Raju GS, Gajula L
Gastrointest Endosc 2004 Feb;59(2):267-79. doi: 10.1016/s0016-5107(03)02110-2. PMID: 14745407

Prognosis

Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Central pontine myelinolysis.
Fersini F, Govi A, Tsokos M
Forensic Sci Med Pathol 2015 Mar;11(1):130-2. Epub 2014 Nov 14 doi: 10.1007/s12024-014-9628-6. PMID: 25395281
Treatment of actively bleeding Mallory-Weiss syndrome: epinephrine injection or band ligation?
Gawrieh S, Shaker R
Curr Gastroenterol Rep 2005 Jun;7(3):175. PMID: 15913474
The Mallory-Weiss-syndrome: a clinical study of 20 cases.
Knoblauch M, Stevka E, Lämmli J, Schauwecker H, Deyhle P, Frey P, Säuberli H
Endoscopy 1976 Feb;8(1):5-9. doi: 10.1055/s-0028-1098366. PMID: 1088363
The Mallory-Weiss syndrome.
Nielsen PE, Zachariae F
Acta Pathol Microbiol Scand Suppl 1970;212:Suppl 212:166+. PMID: 5267087

Clinical prediction guides

Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
The prediction value of scoring systems in Mallory-Weiss syndrome patients.
He L, Li ZB, Zhu HD, Wu XL, Tian DA, Li PY
Medicine (Baltimore) 2019 May;98(22):e15751. doi: 10.1097/MD.0000000000015751. PMID: 31145291Free PMC Article
Asymptomatic Free Air Caused by Mallory-Weiss Tears during Endoscopy.
Kono T, Watari J, Hara K, Ikeda H, Tomita T, Oshima T, Fukui H, Sasako M, Miwa H
Intern Med 2015;54(15):1865-8. Epub 2015 Aug 1 doi: 10.2169/internalmedicine.54.4375. PMID: 26234226
Endoscopic band ligation could decrease recurrent bleeding in Mallory-Weiss syndrome as compared to haemostasis by hemoclips plus epinephrine.
Lecleire S, Antonietti M, Iwanicki-Caron I, Duclos A, Ramirez S, Ben-Soussan E, Hervé S, Ducrotté P
Aliment Pharmacol Ther 2009 Aug 15;30(4):399-405. Epub 2009 May 26 doi: 10.1111/j.1365-2036.2009.04051.x. PMID: 19485979
Hemorrhage from gastric mucosal tears complicating cardiopulmonary resuscitation.
McDonnell PJ, Hutchins GM, Hruban RH, Brown CG
Ann Emerg Med 1984 Apr;13(4):230-3. doi: 10.1016/s0196-0644(84)80468-0. PMID: 6608297

Recent systematic reviews

Endoscopic clipping for acute nonvariceal upper-GI bleeding: a meta-analysis and critical appraisal of randomized controlled trials.
Yuan Y, Wang C, Hunt RH
Gastrointest Endosc 2008 Aug;68(2):339-51. doi: 10.1016/j.gie.2008.03.1122. PMID: 18656600

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