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Disorder of hair

MedGen UID:
42323
•Concept ID:
C0018500
•
Disease or Syndrome
Synonyms: Hair Disease; Hair Diseases
SNOMED CT: Disorder of hair (279425004)

Definition

A non-neoplastic or neoplastic disorder involving the hair. Representative examples include folliculitis, alopecia, tricholemmoma, and pilomatrical carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of hair

Professional guidelines

PubMed

Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata.
Kaplan AL, Olsen EA
J Am Acad Dermatol 2004 Jun;50(6):941-3. doi: 10.1016/j.jaad.2004.01.046. PMID: 15153898

Recent clinical studies

Etiology

Shared Decision-Making, Therapeutic Choice, and Decisional Regret in Patients With Alopecia Areata.
Reyes-Hadsall S, Drake L, Han JJ, Lee KJ, Zhou G, Mostaghimi A, Huang KP
JAMA Dermatol 2022 Oct 1;158(10):1187-1191. doi: 10.1001/jamadermatol.2022.3025. PMID: 35976667Free PMC Article
Clinical efficacy of mychophenolate mofetil in treating lichen planopilaris.
Azizpour A, Hatami P, Lajevardi V, Mohammadi M, Aryanian Z, Mohandesi NA
Dermatol Ther 2022 Aug;35(8):e15625. Epub 2022 Jun 27 doi: 10.1111/dth.15625. PMID: 35674693
Failure of Anakinra in a Case of Severe Hidradenitis Suppurativa.
Russo V, Alikhan A
J Drugs Dermatol 2016 Jun 1;15(6):772-4. PMID: 27272089
Pseudofolliculitis cutis: a vexing disorder of hair growth.
Jasterzbski TJ, Schwartz RA
Br J Dermatol 2015 Apr;172(4):878-84. Epub 2015 Feb 25 doi: 10.1111/bjd.13427. PMID: 25255890
Treatment of trichostasis spinulosa with a 755-nm long-pulsed alexandrite laser.
Toosi S, Ehsani AH, Noormohammadpoor P, Esmaili N, Mirshams-Shahshahani M, Moineddin F
J Eur Acad Dermatol Venereol 2010 Apr;24(4):470-3. Epub 2009 Sep 23 doi: 10.1111/j.1468-3083.2009.03448.x. PMID: 19778356

Diagnosis

Alopecia Areata: The Clinician and Patient Voice.
Tosti A
J Drugs Dermatol 2023 Oct 1;22(10):967-975. doi: 10.36849/JDD.SF396143. PMID: 37801523
Clinical efficacy of mychophenolate mofetil in treating lichen planopilaris.
Azizpour A, Hatami P, Lajevardi V, Mohammadi M, Aryanian Z, Mohandesi NA
Dermatol Ther 2022 Aug;35(8):e15625. Epub 2022 Jun 27 doi: 10.1111/dth.15625. PMID: 35674693
Pseudofolliculitis cutis: a vexing disorder of hair growth.
Jasterzbski TJ, Schwartz RA
Br J Dermatol 2015 Apr;172(4):878-84. Epub 2015 Feb 25 doi: 10.1111/bjd.13427. PMID: 25255890
Pathologic changes of skin and hair in ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome.
Dishop MK, Bree AF, Hicks MJ
Am J Med Genet A 2009 Sep;149A(9):1935-41. doi: 10.1002/ajmg.a.32826. PMID: 19697429
Acquired progressive kinking of the hair.
Cullen SI, Fulghum DD
Arch Dermatol 1989 Feb;125(2):252-5. PMID: 2643929

Therapy

Clinical efficacy of mychophenolate mofetil in treating lichen planopilaris.
Azizpour A, Hatami P, Lajevardi V, Mohammadi M, Aryanian Z, Mohandesi NA
Dermatol Ther 2022 Aug;35(8):e15625. Epub 2022 Jun 27 doi: 10.1111/dth.15625. PMID: 35674693
Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child.
Fenniche S, Hammami H, Zaouak A
J Cosmet Laser Ther 2018 Jun;20(3):156-158. Epub 2017 Dec 13 doi: 10.1080/14764172.2017.1383617. PMID: 29020475
Failure of Anakinra in a Case of Severe Hidradenitis Suppurativa.
Russo V, Alikhan A
J Drugs Dermatol 2016 Jun 1;15(6):772-4. PMID: 27272089
Pseudofolliculitis cutis: a vexing disorder of hair growth.
Jasterzbski TJ, Schwartz RA
Br J Dermatol 2015 Apr;172(4):878-84. Epub 2015 Feb 25 doi: 10.1111/bjd.13427. PMID: 25255890
Treatment of trichostasis spinulosa with a 755-nm long-pulsed alexandrite laser.
Toosi S, Ehsani AH, Noormohammadpoor P, Esmaili N, Mirshams-Shahshahani M, Moineddin F
J Eur Acad Dermatol Venereol 2010 Apr;24(4):470-3. Epub 2009 Sep 23 doi: 10.1111/j.1468-3083.2009.03448.x. PMID: 19778356

Prognosis

Alopecia Areata: The Clinician and Patient Voice.
Tosti A
J Drugs Dermatol 2023 Oct 1;22(10):967-975. doi: 10.36849/JDD.SF396143. PMID: 37801523
A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.
Khan AK, Muhammad N, Aziz A, Khan SA, Shah K, Nasir A, Khan MA, Khan S
BMC Med Genet 2017 Apr 12;18(1):42. doi: 10.1186/s12881-017-0402-y. PMID: 28403827Free PMC Article
Failure of Anakinra in a Case of Severe Hidradenitis Suppurativa.
Russo V, Alikhan A
J Drugs Dermatol 2016 Jun 1;15(6):772-4. PMID: 27272089
Pseudofolliculitis cutis: a vexing disorder of hair growth.
Jasterzbski TJ, Schwartz RA
Br J Dermatol 2015 Apr;172(4):878-84. Epub 2015 Feb 25 doi: 10.1111/bjd.13427. PMID: 25255890
Treatment of trichostasis spinulosa with a 755-nm long-pulsed alexandrite laser.
Toosi S, Ehsani AH, Noormohammadpoor P, Esmaili N, Mirshams-Shahshahani M, Moineddin F
J Eur Acad Dermatol Venereol 2010 Apr;24(4):470-3. Epub 2009 Sep 23 doi: 10.1111/j.1468-3083.2009.03448.x. PMID: 19778356

Clinical prediction guides

Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families.
Khan GM, Hassan N, Khan N, Humayun M, Khan K, Khaliq S, Rehman FU, Ahmed S, Shah K, Khan SA, Muhammad N, Wali A, Khan S, Basit S, Ayub M
Int J Dermatol 2019 Aug;58(8):946-952. Epub 2019 May 11 doi: 10.1111/ijd.14480. PMID: 31077348
A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.
Khan AK, Muhammad N, Aziz A, Khan SA, Shah K, Nasir A, Khan MA, Khan S
BMC Med Genet 2017 Apr 12;18(1):42. doi: 10.1186/s12881-017-0402-y. PMID: 28403827Free PMC Article
Failure of Anakinra in a Case of Severe Hidradenitis Suppurativa.
Russo V, Alikhan A
J Drugs Dermatol 2016 Jun 1;15(6):772-4. PMID: 27272089
Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata.
Kaplan AL, Olsen EA
J Am Acad Dermatol 2004 Jun;50(6):941-3. doi: 10.1016/j.jaad.2004.01.046. PMID: 15153898
A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13.
Healy E, Holmes SC, Belgaid CE, Stephenson AM, Mclean WH, Rees JL, Munro CS
Hum Mol Genet 1995 Dec;4(12):2399-402. doi: 10.1093/hmg/4.12.2399. PMID: 8634717

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