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Granuloma inguinale

MedGen UID:
42291
•Concept ID:
C0018190
•
Disease or Syndrome
Synonym: Donovanosis
SNOMED CT: Granuloma inguinale (28867007); Granuloma venereum (28867007); Donovanosis (28867007); Ulcerating granuloma pudendi (28867007); Infection due to Calymmatobacterium granulomatis (28867007); Infection due to Donovania granulomatis (28867007); Pudendal ulcer (28867007); Granuloma Donovani (28867007); GI - Granuloma inguinale (28867007)
 
Monarch Initiative: MONDO:0005777

Definition

A condition resulting from infection by Klebsiella granulomati, which is characterized by ulcerative lesions of the genitalia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranuloma inguinale

Professional guidelines

PubMed

Diagnosis and management of genital ulcers.
Roett MA, Mayor MT, Uduhiri KA
Am Fam Physician 2012 Feb 1;85(3):254-62. PMID: 22335265
The diagnosis and treatment of donovanosis (granuloma inguinale).
Richens J
Genitourin Med 1991 Dec;67(6):441-52. doi: 10.1136/sti.67.6.441. PMID: 1774048Free PMC Article
Diagnosis and management of sexually transmitted genital lesions.
Nettina SL, Kauffman FH
Nurse Pract 1990 Jan;15(1):20-6, 31, 34-9. PMID: 2405300

Recent clinical studies

Etiology

Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Donovanosis: an update.
O'Farrell N
Int J STD AIDS 2001 Jul;12(7):423-7. doi: 10.1258/0956462011923435. PMID: 11394976
Diagnosis and management of sexually transmitted genital lesions.
Nettina SL, Kauffman FH
Nurse Pract 1990 Jan;15(1):20-6, 31, 34-9. PMID: 2405300
Granuloma inguinale.
Rosen T, Tschen JA, Ramsdell W, Moore J, Markham B
J Am Acad Dermatol 1984 Sep;11(3):433-7. doi: 10.1016/s0190-9622(84)70186-1. PMID: 6384290

Diagnosis

Donovanosis.
Belda Junior W
An Bras Dermatol 2020 Nov-Dec;95(6):675-683. Epub 2020 Sep 17 doi: 10.1016/j.abd.2020.07.002. PMID: 33069513Free PMC Article
Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Sexually transmitted infections.
Fuchs W, Brockmeyer NH
J Dtsch Dermatol Ges 2014 Jun;12(6):451-63. doi: 10.1111/ddg.12310. PMID: 24889293
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Donovanosis.
Velho PE, Souza EM, Belda Junior W
Braz J Infect Dis 2008 Dec;12(6):521-5. doi: 10.1590/s1413-86702008000600015. PMID: 19287842

Therapy

Sexually Transmitted Diseases in the Emergency Department.
Pfennig CL
Emerg Med Clin North Am 2019 May;37(2):165-192. doi: 10.1016/j.emc.2019.01.001. PMID: 30940365
Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Sexually transmitted infections.
Fuchs W, Brockmeyer NH
J Dtsch Dermatol Ges 2014 Jun;12(6):451-63. doi: 10.1111/ddg.12310. PMID: 24889293
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Granuloma inguinale.
Hogarth WP, Hogarth RW
Can Med Assoc J 1966 Apr 23;94(17):916-7. PMID: 4952373Free PMC Article

Prognosis

Donovanosis With Bowen Disease.
Narang T, Manhas A, Kumar B
Skinmed 2017;15(1):73-75. Epub 2017 Feb 1 PMID: 28270316
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Disseminated donovanosis (granuloma inguinale) causing spinal cord compression: case report and review of donovanosis involving bone.
Paterson DL
Clin Infect Dis 1998 Feb;26(2):379-83. doi: 10.1086/516327. PMID: 9502458
A serological test for granuloma inguinale.
Freinkel AL, Dangor Y, Koornhof HJ, Ballard RC
Genitourin Med 1992 Aug;68(4):269-72. doi: 10.1136/sti.68.4.269. PMID: 1398665Free PMC Article
Granuloma inguinale.
Rosen T, Tschen JA, Ramsdell W, Moore J, Markham B
J Am Acad Dermatol 1984 Sep;11(3):433-7. doi: 10.1016/s0190-9622(84)70186-1. PMID: 6384290

Clinical prediction guides

Cutaneous metastases of rectal mucinous adenocarcinoma mimicking granuloma inguinale.
Balta I, Vahaboglu G, Karabulut AA, Yetisir F, Astarci M, Gungor E, Eksioglu M
Intern Med 2012;51(17):2479-81. Epub 2012 Sep 1 doi: 10.2169/internalmedicine.51.7802. PMID: 22975572
Facial and oral aspects of some venereal and tropical diseases.
Ramos-E-Silva M
Acta Dermatovenerol Croat 2004;12(3):173-80. PMID: 15369643
A serological test for granuloma inguinale.
Freinkel AL, Dangor Y, Koornhof HJ, Ballard RC
Genitourin Med 1992 Aug;68(4):269-72. doi: 10.1136/sti.68.4.269. PMID: 1398665Free PMC Article
Sexually transmitted diseases in adolescents: update 1991.
Rosenfeld WD
Pediatr Ann 1991 Jun;20(6):303-12. doi: 10.3928/0090-4481-19910601-07. PMID: 1861893
Accuracy of clinical diagnosis of genital ulcer disease.
Dangor Y, Ballard RC, da L Exposto F, Fehler G, Miller SD, Koornhof HJ
Sex Transm Dis 1990 Oct-Dec;17(4):184-9. doi: 10.1097/00007435-199010000-00007. PMID: 2175951

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