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Avian influenza

MedGen UID:
42091
Concept ID:
C0016627
Disease or Syndrome
Synonyms: Avian Flu; Avian Influenza; Avian Influenzas; Flu, Avian; Fowl Plague; Influenza in Bird; Influenza in Birds; Influenza, Avian; Influenzas, Avian; Plague, Fowl
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018695
Orphanet: ORPHA454836

Definition

A rare, infectious disease characterized by variable severity and outcome, ranging from mild upper respiratory tract infection with fever and cough, to influenza-like illness with rapid progression to severe pneumonia, sepsis with shock, acute respiratory distress syndrome and even death. Additional manifestations may include conjunctivitis, nausea, abdominal pain, diarrhea, vomiting, multiple organ dysfunction, and encephalopathy. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAvian influenza

Professional guidelines

PubMed

Ahrens AK, Pohlmann A, Grund C, Harder T, Beer M
Emerg Infect Dis 2024 Aug;30(8):1737-1739. Epub 2024 Jul 10 doi: 10.3201/eid3008.240103. PMID: 38986148Free PMC Article
Baz M, Subbarao K
Lancet Infect Dis 2015 Mar;15(3):251-3. Epub 2015 Feb 5 doi: 10.1016/S1473-3099(15)70019-8. PMID: 25662593
Jian SW, Liu DP, Chang FY
J Formos Med Assoc 2014 Jul;113(7):397-9. Epub 2014 Mar 13 doi: 10.1016/j.jfma.2014.02.001. PMID: 24630489

Recent clinical studies

Etiology

Burki T
Lancet Infect Dis 2023 Sep;23(9):e343-e344. doi: 10.1016/S1473-3099(23)00508-X. PMID: 37633299
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article
Uyeki TM, Peiris M
Infect Dis Clin North Am 2019 Dec;33(4):907-932. doi: 10.1016/j.idc.2019.07.003. PMID: 31668198
Suttie A, Deng YM, Greenhill AR, Dussart P, Horwood PF, Karlsson EA
Virus Genes 2019 Dec;55(6):739-768. Epub 2019 Aug 19 doi: 10.1007/s11262-019-01700-z. PMID: 31428925Free PMC Article
Lycett SJ, Duchatel F, Digard P
Philos Trans R Soc Lond B Biol Sci 2019 Jun 24;374(1775):20180257. doi: 10.1098/rstb.2018.0257. PMID: 31056053Free PMC Article

Diagnosis

Kang M, Wang LF, Sun BW, Wan WB, Ji X, Baele G, Bi YH, Suchard MA, Lai A, Zhang M, Wang L, Zhu YH, Ma L, Li HP, Haerheng A, Qi YR, Wang RL, He N, Su S
Lancet Infect Dis 2024 Aug;24(8):e522-e531. Epub 2024 Jun 12 doi: 10.1016/S1473-3099(24)00234-2. PMID: 38878787
Fu X, Wang Q, Ma B, Zhang B, Sun K, Yu X, Ye Z, Zhang M
Int J Mol Sci 2023 Dec 5;24(24) doi: 10.3390/ijms242417157. PMID: 38138987Free PMC Article
Vet Rec 2023 Apr;192(8):336-337. doi: 10.1002/vetr.2978. PMID: 37084226
Yang R, Sun H, Gao F, Luo K, Huang Z, Tong Q, Song H, Han Q, Liu J, Lan Y, Qi J, Li H, Chen S, Xu M, Qiu J, Zeng G, Zhang X, Huang C, Pei R, Zhan Z, Ye B, Guo Y, Zhou Y, Ye W, Yao D, Ren M, Li B, Yang J, Wang Y, Pu J, Sun Y, Shi Y, Liu WJ, Ou X, Gao GF, Gao L, Liu J
Lancet Microbe 2022 Nov;3(11):e824-e834. Epub 2022 Sep 14 doi: 10.1016/S2666-5247(22)00192-6. PMID: 36115379
McArthur DB
Nurs Clin North Am 2019 Jun;54(2):297-311. Epub 2019 Mar 27 doi: 10.1016/j.cnur.2019.02.006. PMID: 31027668Free PMC Article

Therapy

Cargnin Faccin F, Perez DR
Hum Vaccin Immunother 2024 Dec 31;20(1):2347019. Epub 2024 May 28 doi: 10.1080/21645515.2024.2347019. PMID: 38807261Free PMC Article
Whitaker JA, Sahly HME, Healy CM
Curr Opin Infect Dis 2023 Oct 1;36(5):385-393. Epub 2023 Jul 18 doi: 10.1097/QCO.0000000000000948. PMID: 37462930
Liang Y
Virulence 2023 Dec;14(1):2223057. doi: 10.1080/21505594.2023.2223057. PMID: 37339323Free PMC Article
Gómez-Carballa A, Pardo-Seco J, Bello X, Martinón-Torres F, Salas A
Trends Genet 2021 Dec;37(12):1069-1080. Epub 2021 Sep 8 doi: 10.1016/j.tig.2021.09.003. PMID: 34556337Free PMC Article
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article

Prognosis

Morens DM, Park J, Taubenberger JK
Sci Transl Med 2023 Oct 18;15(718):eadj2379. doi: 10.1126/scitranslmed.adj2379. PMID: 37851826
Pinto RM, Bakshi S, Lytras S, Zakaria MK, Swingler S, Worrell JC, Herder V, Hargrave KE, Varjak M, Cameron-Ruiz N, Collados Rodriguez M, Varela M, Wickenhagen A, Loney C, Pei Y, Hughes J, Valette E, Turnbull ML, Furnon W, Gu Q, Orr L, Taggart A, Diebold O, Davis C, Boutell C, Grey F, Hutchinson E, Digard P, Monne I, Wootton SK, MacLeod MKL, Wilson SJ, Palmarini M
Nature 2023 Jul;619(7969):338-347. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06261-8. PMID: 37380775
Bi Y, Chen Q, Wang Q, Chen J, Jin T, Wong G, Quan C, Liu J, Wu J, Yin R, Zhao L, Li M, Ding Z, Zou R, Xu W, Li H, Wang H, Tian K, Fu G, Huang Y, Shestopalov A, Li S, Xu B, Yu H, Luo T, Lu L, Xu X, Luo Y, Liu Y, Shi W, Liu D, Gao GF
Cell Host Microbe 2016 Dec 14;20(6):810-821. Epub 2016 Dec 1 doi: 10.1016/j.chom.2016.10.022. PMID: 27916476
Moore DA, Sharland M, Friedland JS
Curr Opin Pulm Med 1999 May;5(3):157-63. doi: 10.1097/00063198-199905000-00006. PMID: 10228740
Hoey J
CMAJ 1998 Feb 10;158(3):369. PMID: 9484264Free PMC Article

Clinical prediction guides

Morens DM, Park J, Taubenberger JK
Sci Transl Med 2023 Oct 18;15(718):eadj2379. doi: 10.1126/scitranslmed.adj2379. PMID: 37851826
Pepin KM, Leach CB, Barrett NL, Ellis JW, VanDalen KK, Webb CT, Shriner SA
mBio 2023 Oct 31;14(5):e0086223. Epub 2023 Sep 28 doi: 10.1128/mbio.00862-23. PMID: 37768062Free PMC Article
Saadh MJ, Aggag MM, Alboghdadly A, Kharshid AM, Aldalaen SM, Abdelrazek MA
Microb Pathog 2021 Sep;158:105071. Epub 2021 Jun 26 doi: 10.1016/j.micpath.2021.105071. PMID: 34182075
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article
Ali M, Yaqub T, Mukhtar N, Imran M, Ghafoor A, Shahid MF, Naeem M, Iqbal M, Smith GJD, Su YCF
Emerg Infect Dis 2019 Jan;25(1):136-139. doi: 10.3201/eid2501.180618. PMID: 30561309Free PMC Article

Recent systematic reviews

Purcell R, Giles ML, Crawford NW, Buttery J
Emerg Infect Dis 2025 Jan;31(1):50-56. Epub 2024 Dec 12 doi: 10.3201/eid3101.241343. PMID: 39668388Free PMC Article
Wang W, Chen X, Wang Y, Lai S, Yang J, Cowling BJ, Horby PW, Uyeki TM, Yu H
J Infect Dis 2022 Aug 12;226(1):70-82. doi: 10.1093/infdis/jiaa679. PMID: 33119755Free PMC Article
Fournié G, Høg E, Barnett T, Pfeiffer DU, Mangtani P
Am J Trop Med Hyg 2017 Aug;97(2):376-388. Epub 2017 Jul 27 doi: 10.4269/ajtmh.17-0014. PMID: 28749769Free PMC Article
Baudon E, Peyre M, Peiris M, Cowling BJ
PLoS One 2017;12(6):e0179044. Epub 2017 Jun 7 doi: 10.1371/journal.pone.0179044. PMID: 28591202Free PMC Article
Yang JW, Fan LC, Miao XY, Mao B, Li MH, Lu HW, Liang S, Xu JF
Clin Microbiol Infect 2015 Oct;21(10):956-63. Epub 2015 Jun 27 doi: 10.1016/j.cmi.2015.06.022. PMID: 26123860

Supplemental Content

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