U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fibromyalgia

MedGen UID:
42018
•Concept ID:
C0016053
•
Disease or Syndrome
Synonyms: Diffuse Myofascial Pain Syndrome; Fibromyalgia Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndromes; Fibromyalgias; Fibromyositis Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndromes; Fibrositides; Fibrositis; Muscular Rheumatism; Myofascial Pain Syndrome, Diffuse; Rheumatism, Muscular; Syndrome, Fibromyalgia-Fibromyositis; Syndrome, Fibromyositis-Fibromyalgia; Syndromes, Fibromyalgia-Fibromyositis; Syndromes, Fibromyositis-Fibromyalgia
SNOMED CT: Fibromyalgia (203082005); Muscular rheumatism (203102006); Myofascial pain syndrome (726531007); MPS - myofascial pain syndrome (726531007); Myofascial pain dysfunction syndrome (726531007); Myofascial trigger point syndrome (726531007); Fibromyositis (24693007); Fibrositis (56557000)
 
Monarch Initiative: MONDO:0005546
Orphanet: ORPHA41842

Definition

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [from NCI]

Professional guidelines

PubMed

Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update.
Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D
Int J Mol Sci 2021 Apr 9;22(8) doi: 10.3390/ijms22083891. PMID: 33918736Free PMC Article
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018).
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U
Clin Neurophysiol 2020 Feb;131(2):474-528. Epub 2020 Jan 1 doi: 10.1016/j.clinph.2019.11.002. PMID: 31901449
EULAR revised recommendations for the management of fibromyalgia.
Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT
Ann Rheum Dis 2017 Feb;76(2):318-328. Epub 2016 Jul 4 doi: 10.1136/annrheumdis-2016-209724. PMID: 27377815

Curated

UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

Recent clinical studies

Etiology

Fibromyalgia interventions, obstacles and prospects: narrative review.
Wasti AZ, Mackawy AMH, Hussain A, Huq M, Ahmed H, Memon AG
Acta Myol 2023;42(2-3):71-81. Epub 2023 Sep 30 doi: 10.36185/2532-1900-334. PMID: 38090547Free PMC Article
The diagnosis of fibromyalgia syndrome.
Berwick R, Barker C, Goebel A; guideline development group
Clin Med (Lond) 2022 Nov;22(6):570-574. doi: 10.7861/clinmed.2022-0402. PMID: 36427885Free PMC Article
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Fibromyalgia Pathogenesis and Treatment Options Update.
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414
Worldwide epidemiology of fibromyalgia.
Queiroz LP
Curr Pain Headache Rep 2013 Aug;17(8):356. doi: 10.1007/s11916-013-0356-5. PMID: 23801009

Diagnosis

Fibromyalgia: Diagnosis and Management.
Winslow BT, Vandal C, Dang L
Am Fam Physician 2023 Feb;107(2):137-144. PMID: 36791450
Fibromyalgia: one year in review 2022.
Giorgi V, Sirotti S, Romano ME, Marotto D, Ablin JN, Salaffi F, Sarzi-Puttini P
Clin Exp Rheumatol 2022 Jun;40(6):1065-1072. Epub 2022 Jun 22 doi: 10.55563/clinexprheumatol/if9gk2. PMID: 35748720
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Fibromyalgia: a clinical review.
Clauw DJ
JAMA 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367

Therapy

Acupuncture and Chronic Musculoskeletal Pain.
Zhang Y, Wang C
Curr Rheumatol Rep 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. PMID: 32978666Free PMC Article
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis.
Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC
Pain Physician 2019 May;22(3):241-254. PMID: 31151332
Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Exercise therapy for fibromyalgia.
Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, Overend TJ, Richards RS, Sawant A, Schachter CL
Curr Pain Headache Rep 2011 Oct;15(5):358-67. doi: 10.1007/s11916-011-0214-2. PMID: 21725900Free PMC Article

Prognosis

The association between BNT162b2 vaccinations and incidence of immune-mediated comorbidities.
Shani M, Hermesh I, Feldhamer I, Reges O, Lavie G, Arbel R, Sagy YW
Vaccine 2024 Jul 11;42(18):3830-3837. Epub 2024 May 10 doi: 10.1016/j.vaccine.2024.04.097. PMID: 38729910
Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis.
Coles ML, Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2021 Mar 1;19(1):22. doi: 10.1186/s12969-021-00493-6. PMID: 33648522Free PMC Article
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
AAPT Diagnostic Criteria for Fibromyalgia.
Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ
J Pain 2019 Jun;20(6):611-628. Epub 2018 Nov 16 doi: 10.1016/j.jpain.2018.10.008. PMID: 30453109
Fibromyalgia.
Rahman A, Underwood M, Carnes D
BMJ 2014 Feb 24;348:g1224. doi: 10.1136/bmj.g1224. PMID: 24566297

Clinical prediction guides

Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Chaves C, Bittencourt PCT, Pelegrini A
Pain Med 2020 Oct 1;21(10):2212-2218. doi: 10.1093/pm/pnaa303. PMID: 33118602Free PMC Article
Visualization of Enthesitis by Ultrasound: a Key Diagnostic Tool in Spondyloarthropathy Diagnosis and Management.
Kaeley GS
Curr Rheumatol Rep 2020 Jul 21;22(9):48. doi: 10.1007/s11926-020-00927-2. PMID: 32696194
Functional MRI in rheumatic diseases with a focus on fibromyalgia.
Pamfil C, Choy EHS
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):82-85. Epub 2018 Oct 1 PMID: 30296992
Rheumatic manifestations of hepatitis C virus chronic infection: Indications for a correct diagnosis.
Palazzi C, D'Amico E, D'Angelo S, Gilio M, Olivieri I
World J Gastroenterol 2016 Jan 28;22(4):1405-10. doi: 10.3748/wjg.v22.i4.1405. PMID: 26819509Free PMC Article
Not the Last Word: Fibromyalgia is Real.
Bernstein J
Clin Orthop Relat Res 2016 Feb;474(2):304-9. Epub 2015 Dec 16 doi: 10.1007/s11999-015-4670-6. PMID: 26676117Free PMC Article

Recent systematic reviews

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.
Lepri B, Romani D, Storari L, Barbari V
Int J Environ Res Public Health 2023 Feb 24;20(5) doi: 10.3390/ijerph20054098. PMID: 36901108Free PMC Article
Efficacy of Dry Needling and Acupuncture in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis.
Valera-Calero JA, Fernández-de-Las-Peñas C, Navarro-Santana MJ, Plaza-Manzano G
Int J Environ Res Public Health 2022 Aug 11;19(16) doi: 10.3390/ijerph19169904. PMID: 36011540Free PMC Article
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review.
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...